A5051205428- Reproductive tract infections research
- Advanced Drug Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Pediatric health and respiratory diseases
- Drug Solubulity and Delivery Systems
- Urinary Tract Infections Management
- Asthma and respiratory diseases
- Gut microbiota and health
- Urticaria and Related Conditions
- Advancements in Transdermal Drug Delivery
- Ocular Surface and Contact Lens
- Aerosol Filtration and Electrostatic Precipitation
- Advanced Proteomics Techniques and Applications
- Analytical chemistry methods development
- Cell Image Analysis Techniques
- Bioinformatics and Genomic Networks
- Diphtheria, Corynebacterium, and Tetanus
- Synthesis and Characterization of Heterocyclic Compounds
- Multicomponent Synthesis of Heterocycles
- Pneumonia and Respiratory Infections
- Microencapsulation and Drying Processes
- Cervical Cancer and HPV Research
- Tryptophan and brain disorders
- Corneal Surgery and Treatments
- Vitamin D Research Studies
University of Szeged
2018-2024
Marketed dosage forms fail to deliver anti-tubercular drugs directly the lungs in pulmonary Tuberculosis (TB). Therefore, nanomediated isoniazid (INH)-loaded dry powder for inhalation (Nano-DPI) was developed macrophage-targeted delivery TB. Mannosylated chitosan (MC) and hyaluronic acid (HA) with an affinity surface mannose CD44 receptors of macrophages were used conjugation prepare hybrid nanosuspension by ionic gelation method using cross-linker, sodium tri-polyphosphate (TPP) followed...
Precise spatiotemporal protein organization is critical for fundamental biological processes including cell division. Indeed, aberrant mitosis and mitotic factors are involved in diverse diseases, various cancers, Alzheimer's disease, rare diseases. During mitosis, complex spatial rearrangements regulation ensure the accurate separation of replicated sister chromatids to produce genetically identical daughter cells. Previous studies employed high-throughput methodologies follow specific...
The role of Corynebacterium striatum has been demonstrated in different nosocomial infections. An increasing number publications have its virulence the respiratory tract, especially immunosuppressed patient population. these patients increased significantly during COVID-19 pandemic. For this reason, we aimed to investigate prevalence and antimicrobial resistance pattern species between 2012 2021 at Clinical Center University Szeged, Hungary. Altogether, 498 positive samples were included...
infections are the most prevalent sexually transmitted with potentially debilitating sequelae, such as infertility. Mouse models generally used for vaccine development, to study immune response and histopathology associated
Recently, the number of water insoluble and poorly soluble drug compounds has increased significantly. Therefore, growing interest been witnessed in different particle size reduction techniques to improve dissolution rates, transport characteristics bioavailability drugs. Laser ablation proven be an alternative method production nano- micrometre-sized particles without considerable chemical damage. We present nanosecond laser pastilles distilled water, targeting meloxicam, a nonsteroidal...
The study aimed to prepare ciprofloxacin-loaded polyvinylpyrrolidone electrospun nanofibers for oral drug delivery, using a conventional nozzle-based and lab-built nozzle-free electrospinning equipment. To produce nanofibers, is the process most often used. However, from industry's point of view, does not have sufficiently high productivity. By omitting nozzle, productivity can be increased, so development processes worthwhile. In this study, solution ciprofloxacin was under similar...
Nasal drug delivery has many beneficial properties, such as avoiding the first pass metabolism and rapid onset of action. However, limited residence time on mucosa absorption certain molecules make use various excipients necessary to achieve high bioavailability. The application mucoadhesive polymers can increase contact with nasal mucosa, permeation enhancers enhance drug. We aimed produce nanoparticles containing meloxicam potassium (MEL-P) by spray drying intended for application. Various...
Medications for asthma management consisting of inhaled corticosteroids act by controlling symptoms. However, some patients do not respond to steroid treatment due immunological factors at the cytokine level. Chlamydia pneumoniae (C. pneumoniae) infection is strongly implicated in pathogenesis, causing altered immune responses. We investigated association C. serostatus with production certain cytokines peripheral blood mononuclear cells (PBMCs) steroid-resistant and -sensitive asthmatic...
Neutrophil granulocytes are the major cells involved in Chlamydia trachomatis (C. trachomatis)-mediated inflammation and histopathology. A key protein human intracellular antichlamydial defense is tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) which limits growth of tryptophan auxotroph Chlamydia. Despite its importance, role IDO against neutrophils not well characterized.Global gene expression screen was used to evaluate effect C. serovar D infection on transcriptome...
Two undescribed compounds, 3β,7β-dihydroxy-24-methylenelanosta-8-ene-11-one (1) and neolignane deightonin (4) were isolated from the aerial parts of Euphorbia deightonii Croizat together with six known namely, kansenone (2), euphorbol-7-one (3), dehydrodiconiferyl diacetate (5), marylaurencinol D (6), scoparon (7), 3,4,3'-tri-O-methylellagic acid (8). The structures compounds determined by HRESIMS, 1D (1H, 13C JMOD) 2D NMR (HSQC, HMBC, 1H-1H COSY, NOESY) spectroscopic analysis, comparison...
Cyclodextrins (CD) are used extensively in the pharmaceutical industry to improve water solubility and bioavailability of drugs. Preparing ternary systems by applying a third component can enhance these beneficial effects. The complexation methods same as those two-component complexes. These solvent (co-evaporation, co-precipitation, etc.) or solventless "green" techniques (co-grinding, microwave irradiation, etc.). Using solvent-free is considered be an economically environmentally...
Purpose. Within the community, 10 % of acquired pneumonia is caused by Chlamydia pneumoniae. N-acetyl-cysteine (NAC) one most commonly used mucolytics in respiratory diseases, but its effect on C. pneumoniae infection has not yet been investigated. In this study, our aim was to investigate whether NAC influences replication After determining that does have an replication, alternative drug called Ambroxol (Ax) investigated.Methodology. The vitro and Ax studied pneumoniae-infected A549 McCoy...
The associations between inhaled corticosteroid (ICS) use and pulmonary infections remains controversial. Chlamydia pneumoniae (C. pneumoniae) accounts for asthma exacerbations; however, there are no data regarding ICS effects on C. infections. Thus, we investigated whether fluticasone propionate (FP) or budesonide (BUD) could affect infection in vitro vivo, focusing the possible mechanisms that lead to potential anti-chlamydial outcomes. We performed direct qPCR detect growth infected,...
Ambroxol (Ax) is used as a mucolytics in the treatment of respiratory tract infections. Ax, at general dose for humans, does not alter Chlamydia pneumoniae growth mice. Therefore, we aimed to investigate potential anti-chlamydial effect Ax concentration four timed higher than that human medicine. Mice were infected with C. and 5-mg/kg was administered orally. The number recoverable inclusion-forming units (IFUs) Ax-treated mice significantly lower untreated mRNA expression levels several...
<b>Introduction:</b> Asthma bronchiale can be categorized into different phenotypes on the basis of mechanisms leading to reversible airway obstruction. Response steroid treatments fail due immunological factors at cytokine levels. Chlamydia pneumoniae is an obligate intracellular bacteria and strongly implicated in not just exacerbations, but also asthma pathogenesis, causing persistent or chronic infections altered immune responses. <b>Methods:</b> After enrolling patients with resistant...
<b>Background:</b><i>C. pneumoniae</i> is an obligate intracellular bacterium with biphasic lifecycle. More than 50 % of the adult population worldwide was infected at least one time <i>C. pneumoniae</i>. The infection responsible for respiratory diseases such as bronchitis and pneumonia. identified causative pathogen in 10-15% paediatric patients community-acquired There are few data available on this topic, therefore, our aim to investigate prevalence seropositivity Southern Hungary....
<b>Introduction:</b> Inhaled corticosteroids (ICSs) are known to reduce the incidence of exacerbations in COPD and asthma, however, relationship between ICSs pneumonia is still controversial. <i>Chlamydia pneumoniae</i> (<i>C. pneumoniae</i>) an intracellular bacterium causing community-acquired can lead secondary bacterial infections. To our knowledge, effect inhaled drugs on <i>C. pneumoniae</i>-infected cells unknown. We wanted investigate impact medications growth. <b>Methods:</b> A549...
Our present series of experiments was to create a value-added formulation that has the potential exert powerful and long-lasting antibacterial effect for use in ophthalmology. Erythromycin-loaded polymeric micelles were formulated with micelle size 87.14 nm monodisperse distribution 86.94% encapsulation efficiency. To decrease micelle-like burst these nanoparticles, dispersed Carbopol 934P gel base prolong drug release permeation profile erythromycin. With successful incorporation, short...