A5083108757- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Cell Image Analysis Techniques
- Single-cell and spatial transcriptomics
- Advanced Electron Microscopy Techniques and Applications
- Image Processing Techniques and Applications
- Neuroscience of respiration and sleep
- Genetics and Neurodevelopmental Disorders
- Cannabis and Cannabinoid Research
- Pluripotent Stem Cells Research
- Prenatal Substance Exposure Effects
- Lipid Membrane Structure and Behavior
- Ion channel regulation and function
- Neural dynamics and brain function
- Virus-based gene therapy research
- Advanced Fluorescence Microscopy Techniques
- Advanced Proteomics Techniques and Applications
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Bioinformatics and Genomic Networks
HUN-REN Szegedi Biológiai Kutatóközpont
2024
HUN-REN Institute of Experimental Medicine
2015-2024
Czech Academy of Sciences, Institute of Experimental Medicine
2023
Hungarian Academy of Sciences
2015-2023
Pázmány Péter Catholic University
2020
While our understanding of the nanoscale architecture anterograde synaptic transmission is rapidly expanding, qualitative and quantitative molecular principles underlying distinct mechanisms retrograde communication remain elusive. We show that a particular form tonic cannabinoid signaling essential for setting target cell-dependent variability. It does not require activity two major endocannabinoid-producing enzymes. Instead, by developing workflow physiological, anatomical, measurements at...
Abstract The molecular repertoire of the “Ca2+-signaling toolkit” supports specific kinetic requirements Ca2+-dependent processes in different neuronal types. A well-known example is unique expression pattern calcium-binding proteins, such as parvalbumin, calbindin, and calretinin. These cytosolic Ca2+-buffers control presynaptic somatodendritic a cell-type-specific manner have been used neurochemical markers GABAergic interneuron types for decades. Surprisingly, to date no typifying...
Precise spatiotemporal protein organization is critical for fundamental biological processes including cell division. Indeed, aberrant mitosis and mitotic factors are involved in diverse diseases, various cancers, Alzheimer's disease, rare diseases. During mitosis, complex spatial rearrangements regulation ensure the accurate separation of replicated sister chromatids to produce genetically identical daughter cells. Previous studies employed high-throughput methodologies follow specific...
Abstract A specialized neurogenic niche along the ventricles accumulates millions of progenitor cells in developing brain. After mitosis, fate-committed daughter delaminate from this germinative zone. Considering high number cell divisions and delaminations taking place during embryonic development, brain malformations caused by ectopic proliferation misplaced are relatively rare. Here, we report that a process term developmental anoikis distinguishes pathological detachment normal...
Abstract Numerous imaging techniques are available for observing and interrogating biological samples, several of them can be used consecutively to enable correlative analysis different image modalities with varying resolutions the inclusion structural or molecular information. Achieving accurate registration multimodal images is essential process, but it remains a challenging computer vision task no widely accepted solution. Moreover, supervised methods require annotated data produced by...
Presynaptic CB1 cannabinoid receptors control neurotransmitter release in a synapse-specific manner at different temporal scales. While the molecular mechanisms of on-demand, so-called phasic forms endocannabinoid-mediated synaptic plasticity are well-described, mechanistic attributes persistent, tonic form signaling remain debated. Unlike endocannabinoid signaling, we found that tone controls probability absence two major endocannabinoid-producing enzymes hippocampal GABAergic synapses....
Abstract In light of the astronomical number cell divisions taking place in restricted neurogenic niches, brain malformations caused by ectopic proliferation misplaced progenitor cells are surprisingly rare. Here, we show that a process term developmental anoikis distinguishes abnormal detachment from normal delamination daughter neuroblasts developing mouse neocortex. By using vivo gain-of-function, loss-of-function, and rescue manipulations together with correlated confocal...