A5065978965- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
- Cannabis and Cannabinoid Research
- Neural dynamics and brain function
- Prenatal Substance Exposure Effects
- Receptor Mechanisms and Signaling
- Action Observation and Synchronization
- Neurobiology and Insect Physiology Research
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Cephalopods and Marine Biology
- Sleep and Wakefulness Research
- Neural and Behavioral Psychology Studies
- Motor Control and Adaptation
- Child and Adolescent Psychosocial and Emotional Development
- Maternal Mental Health During Pregnancy and Postpartum
- Photoreceptor and optogenetics research
- Pain Mechanisms and Treatments
- Neurological disorders and treatments
- Child and Animal Learning Development
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Infant Health and Development
University of Lausanne
2019-2024
University of Cagliari
2017-2023
Centro Universitário Filadélfia
2023
Neuroscience Institute
2019-2022
National Academies of Sciences, Engineering, and Medicine
2022
National Research Council
2019-2021
Italian Institute of Technology
2021
Abstract Multimodal astrocyte–neuron communications govern brain circuitry assembly and function 1 . For example, through rapid glutamate release, astrocytes can control excitability, plasticity synchronous activity 2,3 of synaptic networks, while also contributing to their dysregulation in neuropsychiatric conditions 4–7 communicate fast focal they should possess an apparatus for Ca 2+ -dependent exocytosis similar neurons 8–10 However, the existence this mechanism has been questioned 11–13...
Negative emotional contagion-witnessing others in distress-affects an individual's responsivity. However, whether it shapes coping strategies when facing future threats remains unknown. We found that mice briefly observe a conspecific being harmed become resilient, withstanding behavioral despair after adverse experience. Photometric recordings during negative contagion revealed increased serotonin (5-HT) release the lateral habenula. Whereas 5-HT and reduced habenular burst firing, limiting...
Weighing alternatives during reward pursuit is a vital cognitive computation that, when disrupted by stress, yields aspects of neuropsychiatric disorders. To examine the neural mechanisms underlying these phenomena, we employed behavioral task in which mice were confronted and its omission (i.e., error). The experience error outcomes engaged neuronal dynamics within lateral habenula (LHb), subcortical structure that supports appetitive behaviors susceptible to stress. A high incidence errors...
Cannabis use among pregnant women is increasing worldwide along with permissive sociocultural attitudes toward it. Prenatal cannabis exposure (PCE), however, associated adverse outcome offspring, ranging from reduced birth weight to child psychopathology. We have previously shown that male rat offspring prenatally exposed Δ9-tetrahydrocannabinol (THC), a model of PCE, exhibit extensive molecular, cellular, and synaptic changes in dopamine neurons the ventral tegmental area (VTA), resulting...
Abstract Appropriate behavioural strategies to cope with unexpected salient stimuli require synergistic neuronal responses in diverse brain regions. Among them, the epithalamic lateral habenula ( LH b) plays a pivotal role processing of aversive valence. Integrated complex motivational circuit, b neurons are indeed excited by stimuli, including footshock (Fs). However, whether such excitation is common feature represented throughout remains unclear. Here, we combined single‐unit...
The brain's ability to associate threats with external stimuli is vital execute essential behaviours including avoidance. Disruption of this process contributes instead the emergence pathological traits which are common in addiction and depression. However, mechanisms neural dynamics at single-cell resolution underlying encoding associative learning remain elusive. Here, employing a Pavlovian discrimination task mice we investigate how neuronal populations lateral habenula (LHb), subcortical...
Opioids are essential drugs for pain management, although long-term use is accompanied by tolerance, necessitating dose escalation, and dependence. Pharmacological treatments that enhance opioid analgesic effects and/or attenuate the development of tolerance (with a desirable opioid-sparing effect in treating pain) actively sought. Among them, N-palmitoylethanolamide (PEA), an endogenous lipid neuromodulator with anti-inflammatory neuroprotective properties, was shown to exert...
The lateral habenula (LHb) integrates aversive information to regulate motivated behaviors. Despite recent advances in identifying neuronal diversity at the molecular level, vivo electrophysiological of LHb neurons remains poorly understood. Understanding this is essential for deciphering how processed LHb. To address gap, we conducted recordings mice and applied unsupervised clustering algorithm analyze firing patterns. This analysis identified four distinct spontaneous patterns neurons,...
Abstract Cannabis use among pregnant women is increasing worldwide along with permissive sociocultural attitudes towards it. Prenatal cannabis exposure (PCE), however, associated adverse outcome offspring ranging from reduced birth weight to child psychopathology. We have previously shown that male rat prenatally exposed Δ9-tetrahydrocannabinol (THC), a model of PCE, exhibit extensive molecular, cellular and synaptic changes in dopamine neurons the ventral tegmental area (VTA), resulting...
Abstract The nervous system can associate neutral cues with rewards to promote appetitive adaptive behaviors. lateral habenula (LHb) contributes such behaviors as and reward-predictive inhibit this structure engage LHb-to-dopamine circuits. However, the mechanistic understanding of reward encoding within LHb remains unknown. We report that, in mice, acquisition anticipatory licking a reward-conditioning task potentiates postsynaptic GABAergic transmission, leaving excitatory synapses...
Abstract The plasticity of glutamatergic transmission in the Ventral Tegmental Area (VTA) represents a fundamental mechanism modulation dopamine neuron burst firing and phasic release at VTA target regions. These processes encode basic behavioral responses, including locomotor activity, learning motivated-behaviors. Here we describe hitherto unidentified long-lasting potentiation synapses on DA neurons. We found that astrocytes respond to bursts with Ca2+ elevations require activation...