A5005264920- Neuroscience and Neuropharmacology Research
- Axon Guidance and Neuronal Signaling
- Neural dynamics and brain function
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Gut microbiota and health
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Photoreceptor and optogenetics research
- Zebrafish Biomedical Research Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neural Engineering
- Ion channel regulation and function
- Astrophysics and Cosmic Phenomena
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Estrogen and related hormone effects
- Memory and Neural Mechanisms
- Child and Adolescent Psychosocial and Emotional Development
- Particle physics theoretical and experimental studies
- Treatment of Major Depression
- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
- Immune Cell Function and Interaction
- Advanced Memory and Neural Computing
Yokohama City University
2016-2025
Noguchi Hospital
2025
Kansai Electric Power (Japan)
2025
Kansai Electric Power Hospital
2025
Tokyo Medical and Dental University
2009-2024
The University of Tokyo
1994-2024
Sysmex (Japan)
2024
Iwate Medical University
2022-2024
National Institute on Alcohol Abuse and Alcoholism
2024
Kyoto University
2020-2023
Class 1 and 3 semaphorins repulse axons but bind to different cell surface proteins. We find that the two known semaphorin-binding proteins, plexin (Plex 1) neuropilin-1 (NP-1), form a stable complex. Plex alone does not semaphorin-3A (Sema3A), NP-1/Plex complex has higher affinity for Sema3A than NP-1 alone. While binding alter nonneuronal morphology, interaction with complexes induces adherent cells round up. Expression of dominant-negative in sensory neurons blocks Sema3A-induced growth...
The mechanisms underlying experience-dependent plasticity in the brain may depend on AMPA subclass of glutamate receptors (AMPA-Rs). We examined trafficking AMPA-Rs into synapses developing rat barrel cortex. In vivo gene delivery was combined with vitro recordings to show that experience drives recombinant GluR1, an AMPA-R subunit, formed between layer 4 and 2/3 neurons. Moreover, expression GluR1 cytoplasmic tail, a construct inhibits synaptic endogenous during long-term potentiation,...
Somatosensory axon outgrowth is repulsed when soluble semaphorin D (semD) binds to growth cone neuropilin-1 (Npn-1). Here, semD ligand binding studies of Npn-1 mutants demonstrate that the sema domain amino-terminal quarter, or complement-binding (CUB) domain, Npn-1. By herpes simplex virus– (HSV-) mediated expression in chick retinal ganglion cells, we show semD-induced collapse requires two segments ectodomain Npn-1, CUB and juxtamembrane portion, MAM (meprin, A5, μ) domain. In contrast,...
Learning induces plastic changes in synapses. However, the regulatory molecules that orchestrate learning-induced synaptic are largely unknown. Although it is well established cholinergic inputs from medial septum modulate learning and memory, evidence for regulation of plasticity lacking. Here we find activation muscarinic acetylcholine (ACh) receptors (mAChRs) mediates contextual fear learning-driven strengthening hippocampal excitatory pyramidal synapses through incorporation AMPA-type...
The hippocampus plays a central role in learning and memory. Although synaptic delivery of AMPA-type glutamate receptors (AMPARs) contributes to experience-dependent strengthening, its hippocampus-dependent remains elusive. By combining viral-mediated vivo gene with vitro patch-clamp recordings, we found that the inhibitory avoidance task, contextual fear-learning paradigm, delivered GluR1-containing AMPARs into CA3-CA1 synapses dorsal hippocampus. To block endogenous AMPARs, expressed...
The aim of this study was to investigate the effects 24-week synbiotic supplementation on chronic inflammation and gut microbiota in obese patients with type 2 diabetes. We randomized 88 diabetes one two groups for 24 weeks: control or (Lacticaseibacillus paracasei strain Shirota (previously Lactobacillus casei Shirota) Bifidobacterium breve Yakult, galactooligosaccharides). primary endpoint change interleukin-6 from baseline weeks. Secondary endpoints were evaluation feces blood, fecal...
To better understand the role of peptide growth factors in sex steroid hormone-mediated female reproductive tract, effect estrogen on expression transforming factor-alpha (TGF alpha) mouse uterus was investigated. Our results show that induces TGF alpha mRNA a dose- and time-dependent manner. The up-regulation transcripts occurs predominantly uterine epithelial cells. RIA Western blot analysis demonstrate immunoreactive protein is secreted at high levels into luminal fluid after treatment....
Abstract A structured interview was used to examine the 1‐year incidence and prevalence of depression among 116 first‐year university students. While 24 subjects (20.7%) met Diagnostic Statistical Manual Mental Disorders 4th ed. (DSM‐IV) criteria for Major Depressive Episode (MDE), 62 (53.4%) 3rd Revised (DSM‐III‐R) MDE, 27 (23.3%) also Research Criteria (RDC) Disorder (MDD) 12 months prior interview. Moreover, 23 (19.8%) had onset DSM‐IV 54 (46.6%) DSM‐III‐R RDC MDD, during same time...
Collapsin response mediator protein 1 (CRMP1) is one of the CRMP family members that mediates signal transduction axonal guidance and neuronal migration. We show here evidence CRMP1 involved in semaphorin3A (Sema3A)-induced spine development cerebral cortex. In cultured cortical neurons from crmp1+/- mice, Sema3A increased density clusters synapsin I postsynaptic density-95, but this increase was markedly attenuated crmp1-/- mice. This attenuation also seen cyclin-dependent kinase 5...
Brain damage such as stroke is a devastating neurological condition that may severely compromise patient quality of life. No effective medication-mediated intervention to accelerate rehabilitation has been established. We found small compound, edonerpic maleate, facilitated experience-driven synaptic glutamate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic-acid) receptor delivery and resulted in the acceleration motor function recovery after cortex cryoinjury mice training-dependent...
Previous findings suggested that Lactobacillus rhamnosus CRL1505 is able to increase resistance of children intestinal viral infections. However, the cells, cytokines and receptors involved in immunoregulatory effect this probiotic strain have not been fully characterized. We aimed gain insight into mechanisms immunomodulatory therefore evaluated vitro crosstalk between L. CRL1505, porcine epithelial cells (IECs) antigen presenting (APCs) from swine Peyer's patches order deepen our knowledge...
Ultra-light particles, such as axions, form a macroscopic condensate around highly spinning black hole by the superradiant instability. Due to its nature, opens possibility of detecting axion through gravitational wave observations. However, precise evolution must be known for actual detection. For future observation, we numerically study influence self-interaction, especially interaction between different modes, on in detail. First, focus case when starts with smallest possible angular...