A5009580340- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Drug Transport and Resistance Mechanisms
- Metal complexes synthesis and properties
- Antibiotic Resistance in Bacteria
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Synthesis and Characterization of Heterocyclic Compounds
- Selenium in Biological Systems
- Essential Oils and Antimicrobial Activity
- Bioactive Natural Diterpenoids Research
- Synthesis and Biological Evaluation
- Antibiotics Pharmacokinetics and Efficacy
- DNA and Nucleic Acid Chemistry
- Organoselenium and organotellurium chemistry
- Ferrocene Chemistry and Applications
- Crystal structures of chemical compounds
- Microbial Natural Products and Biosynthesis
- Natural product bioactivities and synthesis
- Escherichia coli research studies
- Free Radicals and Antioxidants
- Pharmaceutical and Antibiotic Environmental Impacts
- Antimicrobial Resistance in Staphylococcus
University of Szeged
2016-2025
MTA-SZTE Research Group on Artificial Intelligence
2021-2022
University of Lisbon
2019
Faculty (United Kingdom)
2016-2019
Universidade Nova de Lisboa
2009-2011
Instituto de Medicina Tropical
2008-2011
Meikai University
2008
University of Cambridge
2008
Indian Institute of Science Bangalore
2008
Scripps Research Institute
2008
This review discusses the relationship of efflux pump (EP) system Gram-negative bacteria to other antibiotic resistance mechanisms bacterium such as quorum sensing, biofilms, two component regulons, etc. The genetic responses a an that render it immune are also discussed. Lastly, methods have been developed for identification over-express their EP presented in detail. Phenothiazines well-known antipsychotic drugs with reported activity against bacterial EPs and ancillary organism. Therefore...
Malignant diseases present a serious public health burden and their treatment with traditional chemotherapy cannot be considered an all-round solution, due to toxic side effects. Selenium compounds (Se-compounds) have received substantial attention in medicinal chemistry, especially experimental chemotherapy, both as cytotoxic agents adjuvants chemotherapy. A checkerboard microplate method was applied study the drug interactions of Se-compounds clinically relevant chemotherapeutic drugs...
Nigella sativa essential oil (EO) and its compounds (thymoquinone, carvacrol, p-cymene) have a broad antimicrobial spectrum. The aim of this study was to investigate the resistance modifying activity N. EO, thymoquinone, p-cymene against one methicillin susceptible resistant Staphylococcus aureus strain. were assessed for modulation (by broth microdilution), inhibition efflux ethidium bromide [EtBr] accumulation assay), relative expression mepA gene real-time reverse transcriptase...
Multidrug resistance of cancer cells to cytotoxic drugs still remains a major obstacle the success chemotherapy in treatment. The development new drug candidates which may serve as P-glycoprotein (P-gp) efflux pump inhibitors is promising strategy. Selenium analogues natural products, such flavonoids, offer an interesting motif from perspective design. Herein, we report biological evaluation novel hybrid compounds, bearing both flavone core (compounds 1–3) or bioisosteric analogue 4–6) and...
Although accumulating evidence suggests that the crosstalk between malignant cells and cancer-associated fibroblasts (CAFs) actively contributes to tumour growth metastatic dissemination, therapeutic strategies targeting stroma are still not common in clinical practice. Metal-based nanomaterials have been shown exert excellent cytotoxic anti-cancerous activities, however, their effects on reactive never investigated details. Thus, using feasible vitro vivo systems model microenvironment, we...
As a consequence of the worsening situation with multidrug-resistant (MDR) pathogens and disparity in commercialization novel antimicrobial agents, scientists have been prompted to seek out new compounds activity from wide range sources, including medicinal plants. In present study, antibacterial, antifungal, anti-virulence, resistance-modulating properties essential oil Sardinian endemic
Origanum majorana L. is a widely used medicinal plant; its distilled oil and preparations are extensively utilised in the phytotherapy food industries. The objective of this study to evaluate extracts essential (EO) L, monoterpenes for antimicrobial, bacterial multidrug resistance reversing, biofilm formation inhibitory potency. composition EO n-hexane extract was characterized by GC-MS. In terpinen-4-ol (24.92%), trans-sabinene hydrate (25.18%), γ-terpinene (6.48%), cis-sabinene (5.44%),...
We report the synthesis and characterization of a group benzoylhydrazones (Ln) derived from 2-carbaldehyde-8-hydroxyquinoline benzylhydrazides containing distinct para substituents (R = H, Cl, F, CH3, OCH3, OH NH2, for L1-7, respectively; in L8 isonicotinohydrazide was used instead benzylhydrazide). Cu(II) complexes were prepared by reaction each benzoylhydrazone with acetate. All compounds characterized elemental analysis mass spectrometry as well FTIR, UV-visible absorption, NMR or...
Salvia officinalis L., Sambucus nigra Matricaria chamomilla Agrimonia eupatoria Fragaria vesca L. and Malva sylvestris are plants that have a long tradition in European folk medicine. To this day, they part of medicinal teas or creams help with the healing skin wounds treatment respiratory intestinal infections. However, so far these not been investigated more deeply than their direct antibacterial effect. Our research is focused on adjuvants inhibit mechanism antibiotic resistance modulate...
Metals are important cofactors in the metabolic processes of cyanobacteria, including photosynthesis, cellular respiration, DNA replication, and biosynthesis primary secondary metabolites. In adaptation to marine environment, cyanobacteria use metallophores acquire trace metals when necessary as well reduce potential toxicity from excessive metal concentrations. Leptochelins A–C were identified structurally novel three geographically dispersed genus Leptothoe. Determination complex...
Abstract Fractionated extracts of persimmon ( Diospyros kaki ) peels were studied for cytotoxic activity, multidrug resistance (MDR) reversal anti‐human immunodeficiency virus (HIV) activity and anti‐ Helicobacter pylori H. activity. The potent against human oral squamous cell carcinoma cells (HSC‐2) submandibular gland tumor (HSG) was found in the acetone fractions (A4 A5) with IC 50 ranging from 21 to 59 µg/mL. However, not correlated radical intensity fractions. Three 70% MeOH extract...