A5000482639- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Synthesis and Biological Activity
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Sesquiterpenes and Asteraceae Studies
- Traditional and Medicinal Uses of Annonaceae
- Fungal Biology and Applications
- Phytochemistry and Bioactive Compounds
- Alkaloids: synthesis and pharmacology
- Seaweed-derived Bioactive Compounds
- Marine Biology and Environmental Chemistry
- Cholinesterase and Neurodegenerative Diseases
- Crystallization and Solubility Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Psychedelics and Drug Studies
- Drug Transport and Resistance Mechanisms
- Phytochemistry and Bioactivity Studies
- X-ray Diffraction in Crystallography
- Phytochemical Studies and Bioactivities
- Phytochemical compounds biological activities
- Bioactive Compounds and Antitumor Agents
- Chemical Synthesis and Analysis
King Abdulaziz University
2015-2025
Suez Canal University
2015-2025
Geneva College
2013
Sharif University of Technology
2013
University of Louisiana at Monroe
2004-2010
Cairo University
2010
Virginia Tech
2010
University of Utah
2010
Duke University
2010
University of Mississippi
2004-2009
ABSTRACT A gene cluster for the biosynthesis of a new small cyclic peptide, dubbed trichamide, was discovered in genome global, bloom-forming marine cyanobacterium Trichodesmium erythraeum ISM101 because striking similarities to previously characterized patellamide cluster. The tri consists precursor peptide containing amino acid sequence mature putative heterocyclization gene, an oxidase, two proteases, and hypothetical genes. Based upon detailed analysis, structure predicted trichamide...
Cultivation of the marine cyanobacterium Moorea producens, collected from Nabq Mangroves in Gulf Aqaba (Red Sea), led to isolation new apratoxin analogues H (1) and A sulfoxide (2), together with known apratoxins A–C, lyngbyabellin B, hectochlorin. The absolute configuration these potent cytotoxins was determined by chemical degradation, MS, NMR, CD spectroscopy. Apratoxin contains pipecolic acid place proline residue present A, expanding suite naturally occurring that display amino...
In our search for bioactive metabolites from marine organisms, we have investigated the polar fraction of organic extract Red Sea sponge Theonella swinhoei. Successive chromatographic separations and final HPLC purification potent antifungal afforded a new bicyclic glycopeptide, theonellamide G (1). The structure peptide was determined using extensive 1D 2D NMR high-resolution mass spectral determinations. absolute configuration by chemical degradation spectroscopy. Theonellamide showed...
Metals are important cofactors in the metabolic processes of cyanobacteria, including photosynthesis, cellular respiration, DNA replication, and biosynthesis primary secondary metabolites. In adaptation to marine environment, cyanobacteria use metallophores acquire trace metals when necessary as well reduce potential toxicity from excessive metal concentrations. Leptochelins A–C were identified structurally novel three geographically dispersed genus Leptothoe. Determination complex...
Abstract Non-small cell lung cancer (NSCLC) is a widespread highly malignant type of cancer. Conventional chemotherapeutic drugs may be accompanied by both drug resistance and serious side effects in patients. Therefore, safer more effective medications are urgently needed for the treatment NSCLC. This study investigates mode action 21 phytoconstituents previously isolated from Amaryllidaceous plants Crinum bulbispermum (Burm.f.), Pancratium maritimum L., Hippeastrum vittatum Herbert...
The Red Sea is the home of a rich diversity sponge species with unique ecological adaptations that thrive in its saline, warm, and nutrient-poor waters. sponges offer potential as sources bioactive compounds novel drugs. organic extract Agelas sp. aff. marmarica was investigated for antimicrobial constituents. Through bioassay-guided fractionation fraction on SiO2 Sephadex LH-20, well HPLC purification, three compounds, marmaricines A-C (1-3), were isolated. Structural elucidation performed...
Alcyonaria species are among the important marine invertebrate classes that produce a wealth of chemically diverse bioactive diterpenes. Examples these potent microtubule disruptor sarcodictyins and eleutherobin. The genus Cladiella has proven to be rich source cytotoxic eunicellin-based diterpenoids. Five new eunicellin diterpenes, pachycladins A−E (1−5), were isolated from Red Sea soft coral pachyclados. known sclerophytin A Cladiellisin, 3-acetylcladiellisin, 3,6-diacetylcladiellisin,...
Two new grassypeptolides and a lyngbyastatin analogue, together with the known dolastatin 12, have been isolated from field collections laboratory cultures of marine cyanobacterium Leptolyngbya sp. collected SS Thistlegorm shipwreck in Red Sea. The overall stereostructures D (1) E (2) Ibu-epidemethoxylyngbyastatin 3 (3) were determined by combination 1D 2D NMR experiments, MS analysis, Marfey's methodology, HPLC-MS. Compounds 1 2 contain 2-methyl-3-aminobutyric acid 2-aminobutyric acid,...
In the course of our continuous interest in identifying bioactive compounds from marine microbes, we have investigated a tunicate-derived fungus, Penicillium sp. CYE-87. A new compound with 1,4-diazepane skeleton, terretrione D (2), together known compounds, methyl-2-([2-(1H-indol-3-yl)ethyl]carbamoyl)acetate (1), tryptamine (3), indole-3-carbaldehyde (4), 3,6-diisobutylpyrazin-2(1H)-one (5) and C (6), were isolated The structures established by spectral analysis, including 1D (1H, 13C) 2D...
Marine-derived macrolides latrunculins A and B, of the Red Sea sponge Negombata magnifica, are first marine natural products that have been found to reversibly bind actin monomers disrupt its organization. Latrunculins structurally related many antimicrobial antiangiogenic macrolides. Several grams latrunculin B (1), together with a new named T (2), were isolated from recent collection N. magnifica. Semisynthetic modifications 1, including acetylation, acetalization, N-hydroxymethylation,...
Reinvestigation of the Red Sea sponge Suberea mollis afforded two new bromotyrosine-derived alkaloids, subereamollines A (1) and B (2), brominated phenolic compounds, subereaphenols (7) C (9), known compounds aerothionin (3), homoaerothionin (4), 11,19-dideoxyfistularin-3 (5), aeroplysinin-1 (6), aeroplysinin-2 (8). The structure determination isolated was assigned using one- two-dimensional NMR spectra HRFABMS data. antimicrobial antioxidant activities have been evaluated. Aeroplysinin-1...
The marine-derived macrolides latrunculins A (1) and B, from the Red Sea sponge Negombata magnifica, have been found to reversibly bind actin monomers, forming a 1:1 complex with G-actin disrupting its polymerization. microfilament protein is responsible for several essential functions within cell such as cytokinesis migration. One of main binding pharmacophores 1 was identified C-17 lactol hydroxyl moiety that binds arginine 210 NH. Latrunculin A-17-O-carbamates 2−6 were prepared by...
Potent antifungal cyclic lipopeptides, burkholdines (Bk), were isolated from a culture of Burkholderia ambifaria 2.2N. Bk-1229 (1) and Bk-1097 (2) are octapeptides comprised nonproteinogenic amino acids, including β-hydroxytyrosine, β-hydroxyasparagine, new fatty acyl acid. 1 2 fungicidal against panel fungi with potencies 2−60-fold better than amphotericin B control.
A new collection of several Red Sea sponges was investigated for the discovery potential breast cancer migration inhibitors. Extracts Verongid Pseudoceratina arabica and Suberea mollis were selected. Bioassay-directed fractionation both sponges, using wound-healing assay, resulted into isolation known brominated alkaloids. Active fractions sponge afforded five alkaloids, ceratinines A–E (2–6), together with alkaloids moloka’iamine (1), hydroxymoloka’iamine (7) moloka’iakitamide (8). The...
In a continuation of our efforts to identify bioactive compounds from Red Sea Verongid sponges, the organic extract sponge Suberea species afforded seven including two new dibrominated alkaloids, subereamollines C and D (1 2), together with known aerothionin (3), homoaerothionin (4), aeroplysinin-1 (5), aeroplysinin-2 (6) revised subereaphenol (7) as ethyl 2-(2,4-dibromo-3,6-dihydroxyphenyl)acetate. The structures isolated were assigned by different spectral data optical rotations, 1D (1H...
The bioactive bromotyrosine-derived alkaloids and unique morphologically-defined fibrous skeleton of chitin origin have been found recently in marine demosponges the order Verongiida. sophisticated three-dimensional (3D) structure skeletal chitinous scaffolds supported their use biomedicine, tissue engineering as well diverse modern technologies. goal this study was screening new species Verongiida to find another renewable source naturally prefabricated 3D scaffolds. Special attention paid...
As a part of our ongoing effort to allocate marine microbial bioactive leads, tunicate-derived actinomycete, Streptomyces sp. Did-27, was investigated. Three new 2(1H)-pyrazinones derivatives, (S)-6-(sec-butyl)-3-isopropylpyrazin-2(1H)-one (1), (S)-3-(sec-butyl)-6-isopropylpyrazin-2(1H)-one (2) and (S)-6-(sec-butyl)-3-isobutylpyrazin-2(1H)-one (3), together with the known (1H)-pyrazinones analogues deoxymutaaspergillic acid (4), 3,6-diisobutyl-2(1H)-pyrazinone (5)...
Marine demosponges (Porifera: Demospongiae) are recognized as first metazoans which have developed over millions of years evolution effective survival strategies based on unique metabolic pathways to produce both biologically active secondary metabolites and biopolymer-based stiff skeletons with 3D architecture. Up date, among marine demosponges, only representatives the Verongiida order been known synthetize substances well made structural polysaccharide chitin. This work, our knowledge,...
Marine sponges are found to be a rich source of bioactive compounds which show wide range biological activities including antiviral, antibacterial, and anti-inflammatory activities. This study aimed investigate the possible anti-inflammatory, antioxidant immunomodulator effects methanolic extract Red Sea marine sponge Xestospongia testudinaria. The chemical composition testudinaria was determined using Gas chromatography-mass spectroscopy (GC-MS) analysis. DPPH (2,...
Biological and chemical investigations of the methanolic crude extract Red Sea marine sponge Hyrtios erectus led to isolation a novel azepino-indole-type alkaloid named hyrtiazepine (2) 5-hydroxy-1H-indole-3-carboxylic acid methyl ester (3), together with known metabolites hyrtiosulawesine (1), 5-hydroxyindole-3-carbaldehyde (4), hyrtiosin A (5), B (6). Their structures were elucidated on basis mass spectrometry detailed 2D NMR spectroscopic data. Hyrtiosulawesine (1) displayed significant...