A5082394578- Chemotherapy-induced organ toxicity mitigation
- Pomegranate: compositions and health benefits
- Sesame and Sesamin Research
- Drug-Induced Hepatotoxicity and Protection
- Antioxidant Activity and Oxidative Stress
- Chemotherapy-induced cardiotoxicity and mitigation
- Ovarian function and disorders
- COVID-19 Clinical Research Studies
- Paraoxonase enzyme and polymorphisms
- Natural Antidiabetic Agents Studies
- Seaweed-derived Bioactive Compounds
- Nigella sativa pharmacological applications
- Pregnancy and Medication Impact
- Sirtuins and Resveratrol in Medicine
- Phytochemicals and Antioxidant Activities
- Moringa oleifera research and applications
- SARS-CoV-2 and COVID-19 Research
- Helicobacter pylori-related gastroenterology studies
- Vitamin C and Antioxidants Research
- Bee Products Chemical Analysis
- Dermatological and COVID-19 studies
- Growth Hormone and Insulin-like Growth Factors
- Essential Oils and Antimicrobial Activity
- Echinoderm biology and ecology
- Genomics, phytochemicals, and oxidative stress
Tanta University
2016-2025
King Abdulaziz University
2013-2023
University of Jeddah
2018-2020
Mansoura University
2019
King Abdul Aziz University Hospital
2012
Background: The Pfizer-BioNTech COVID-19 vaccine has recently received emergency approval from the US FDA. mRNA technology was used to manufacture Pfizer vaccine; however, as a pioneering that never been in of vaccines, many people have concerns about vaccine's side effects. Thus, current study aimed track short-term effects vaccine. Methods: information this gathered by Google Form-questionnaire (online survey). results included responses 455 individuals, all whom are Saudi Arabia...
Gastric ulcers are among the most common diseases affecting humans. This study aimed at investigating gastroprotective effects of manuka honey against ethanol‐induced gastric in rats. The mechanism by which exerts its antiulcer potential was elucidated. Four groups rats were used: control, ethanol (ulcer), omeprazole, and honey. Stomachs examined macroscopically for hemorrhagic lesions glandular mucosa, histopathological changes, glycoprotein detection. oxidative stress investigated using...
Cellular inflammation has been recognized as the leading factor in numerous diseases, causing either cell death, organ-specific damage, or genesis of different cancers. Icariin, a flavonol glucoside, extracted from Herba Epimedii, offers various pharmacological activities, including reducing and an antioxidant effect. We aimed to evaluate anti-inflammatory mechanisms icariin focussing on both HO-1/Nrf2 NF-kB pathways. Acute was induced rats via carrageenan this study. Icariin injected dose...
Gastric ulcers are a major problem worldwide with no effective treatment. The objective of this study was to evaluate the use manuka honey in treatment acetic acid‐induced chronic gastric rats. Different groups rats were treated three different concentrations honey. Stomachs checked macroscopically for ulcerative lesions glandular mucosa and microscopically histopathological alterations. Treatment significantly reduced ulcer index maintained glycoprotein content. It also mucosal...
The protective effects of both manuka and talh honeys were assessed using a rat model cisplatin (CISP)-induced hepatotoxicity nephrotoxicity.
Although cisplatin (CIS) is a highly effective anticancer drug, hepatotoxicity one of the most common adverse effects associated with its use. Recently, reactive oxygen species (ROS) and inflammation are suggested to be key factors in pathophysiology CIS-induced acute liver damage. The aim this study investigate possible protective effect proanthocyanidin (PRO) against hepatotoxicity. Rats were divided into four groups: 1, Control; 2, PRO; 3, CIS; 4, PRO + CIS. Biochemical studies...
Cisplatin (Cis) is an effective cancer therapy commonly employed in many therapeutic regimens. However, treatment regimens that contain either a high dose or cumulative doses of Cis could trigger liver damage. A unique study demonstrated captopril (Cap) protects against Cis-induced toxicity, but only some function enzymes and antioxidant were investigated study. Our aims to elucidate the protective mechanism Cap toxicity. Acute toxicity was induced rats by injecting single (7.5 mg/kg) three...
Marine sponges are found to be a rich source of bioactive compounds which show wide range biological activities including antiviral, antibacterial, and anti-inflammatory activities. This study aimed investigate the possible anti-inflammatory, antioxidant immunomodulator effects methanolic extract Red Sea marine sponge Xestospongia testudinaria. The chemical composition testudinaria was determined using Gas chromatography-mass spectroscopy (GC-MS) analysis. DPPH (2,...
Background and Objectives: Studies have noted that some ABO blood types are more susceptible to COVID-19 virus infection. This study aimed further confirm the relationship between different groups on vulnerability, symptoms, cure period, severity among recovered patients. Subjects Methods: cross-sectional approached participants from Arab community via social media (mainly Facebook WhatsApp). The data were collected through two Google Form questionnaires, one for patients (COVID-19 group, n...
Lead (Pb) is widespread toxic metals found in the environment and potential danger to human health. This study investigated possible protective roles of propolis against Pb-induced neurotoxicity. Forty male adult (Swiss albino rats) rats were divided into four groups: Group-I {Control: 1 ml distilled water intraperitoneal (i.p.)}; group-II, received at a dose 50 mg/kg/day daily orally (p.o.); group-III, (Pb treatment: mg/kg i.p.) group-IV (propolis Pb mg propolis/kg p.o. (1 for weeks....
The Food and Drug Administration recently warned of the fatal cardiovascular risks azithromycin in humans. In addition, a published study documented azithromycin‐induced cardiotoxicity rats. This aimed to justify exact events accompanying administration rats, focusing on electrocardiographic, biochemical, histopathological changes. underlying mechanisms were studied regarding reactive oxygen species production, cytokine release, apoptotic cell‐death. Finally, supposed protective effects both...
Antioxidants are one of the effective treatment lines in managing type 2 diabetes (typ2diab) and its complications. Nanoformulations could help ameliorating oral bioavailability biocompatibility properties. Ellagic acid (Ella) is a natural antioxidant compound commonly present fruits. This study examined effect Ella nanoparticles (Ella NPs) alone combined with metformin, standard antidiabetic drug, on controlling blood glucose typ2diab. Forty-eight adult Sprague-Dawley rats were used this...
Objective. To investigate the ability of two-dimensional longitudinal strain echocardiography (2DST), to detect early doxorubicin cardiotoxicity. Patients and Methods. The study included 25 children with newly diagnosed acute lymphoblastic leukemia (ALL) aged 5-15 years 30 healthy control children. They had echocardiographic examination conventional 2-dimensional (2D), pulsed tissue Doppler (PTD), 2DST before within 1 week after treatment. Results. There was no significant difference in left...
Recent studies have demonstrated that marine sponges and their active constituents exhibited several potential medical applications. This study aimed to evaluate the possible hepatoprotective role as well antioxidant effect of Red Sea Suberea mollis sponge extract (SMSE) on carbon tetrachloride- (CCl4-) induced acute liver injury in rats. In vitro activity SMSE was evaluated by 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) assay. Rats were orally administered three different concentrations...
Diabetes mellitus is regarded as a serious chronic disease that carries high risk for considerable complications. In folk medicine, the edible Grewia asiatica fruit used in number of pathological conditions. This study aimed to investigate possible curative effect G. ethanolic extract against streptozotocin- (STZ-) induced hyperglycemia rats. Furthermore, mechanism antihyperglycemic action investigated. Hyperglycemic rats are either treated with 100 or 200 mg/kg/day fruits extract. Serum...
Background and Objective: Ellagic acid (ELL) is a phenolic constituent of natural sources with antioxidant anti-inflammatory activities.The ELL has low bio-availability, therefore nanoparticles (NP ELL) was formulated to determine whether NP could alleviate cisplatin (CISP)-induced hepatotoxicity in comparison high dose regular ELL.Materials Methods: The prepared using an emulsion solvent diffusion technique.Hepatotoxicity induced rats CISP (7.5 mg kgG 1 ).Rats were pre-treated either 10 (10...
Like other vaccines, Pfizer BioNTech's COVID-19 vaccine efficacy against SARS-CoV-2 virus infections begins to decline within a few months after the 2nd dose. On August 12, 2021, FDA allowed additional BioNTch's dose (3rd or booster dose) for individuals with weakened immunity. This study aimed evaluate short-term adverse reactions (ADRs) of and 3rd doses BioNTech vaccine.Information this was collected by Google Form questionnaire (online survey). The results included responses from 442...
The objective of this research was to estimate the kidney-protective properties golden berry (Physalis peruviana L.) fresh juice (GBJ) in rats with streptozotocin (STZ)-induced type 1 diabetes. Thirty male were separated into two groups: control (n=6) and diabetes (n=24) groups. diabetic then subdivided four groups (6 each): untreated diabetes, metformin (Met)-treated diabetic, GBJ-treated GBJ + Met-treated diabetic. treatment duration lasted for eight weeks. findings demonstrated that...
Abstract Millions of individuals worldwide, across all age groups, suffer from the widespread health issue gastric ulcers. In many experiments, cilostazol (Cls), a phosphodiesterase-3 inhibitor, was recently shown to have anti-ulcer activity. Notably, Cls increases expression and transcriptional activity PPAR-γ in vitro vivo. This study aimed evaluate protective effect against ethanol-induced ulcers clarify possible underlying mechanisms with an emphasis on role PPAR-γ. Male albino rats were...