A5034302513- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Lanthanide and Transition Metal Complexes
- Crystallography and molecular interactions
- Organometallic Complex Synthesis and Catalysis
- Radiopharmaceutical Chemistry and Applications
- Click Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Magnetism in coordination complexes
- Advanced biosensing and bioanalysis techniques
- Analytical chemistry methods development
- Organometallic Compounds Synthesis and Characterization
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Nanoparticle-Based Drug Delivery
- Drug Transport and Resistance Mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Trace Elements in Health
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Treatment and Pharmacology
- Electrochemical Analysis and Applications
- Metal-Catalyzed Oxygenation Mechanisms
- Mass Spectrometry Techniques and Applications
University of Vienna
2016-2025
Medical University of Vienna
2016-2025
Translational Research in Oncology
2012-2023
Ludwig Boltzmann Cluster for Cardiovascular Research
2019-2022
Institute of Inorganic Chemistry of the Slovak Academy of Sciences
2004-2021
Faculty (United Kingdom)
2014-2021
Robert Bosch (Germany)
2021
Austrian Economics Center
2015-2020
University of Wisconsin–Madison
2015-2018
Comprehensive Cancer Center Vienna
2011-2017
NKP-1339 is the first-in-class ruthenium-based anticancer drug in clinical development against solid cancer and has recently been studied successfully a phase I trial. Ruthenium compounds such as KP1019 (indazolium trans-[tetrachloridobis(1H-indazole)ruthenate(III)]) (the sodium salt analogue of KP1019, have high tumour targeting potential based (1) on their strong binding to serum proteins albumin transferrin well (2) activation reductive milieu. The redox activity ruthenium believed...
Abstract Hydroxyproline-rich glycoproteins (HRGPs) are a superfamily of plant cell wall proteins that function in diverse aspects growth and development. This consists three members: hyperglycosylated arabinogalactan (AGPs), moderately glycosylated extensins (EXTs), lightly proline-rich (PRPs). Hybrid chimeric versions HRGP molecules also exist. In order to “mine” genomic databases for HRGPs facilitate guide research the field, BIO OHIO software program was developed identifies classifies...
A phase I and pharmacokinetic study was carried out with the new ruthenium complex indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019, FFC14A). Seven patients various types of solid tumours refractory to standard therapy were treated escalating doses KP1019 (25–600 mg) twice weekly for 3 weeks. No dose-limiting toxicity occurred. Ruthenium plasma concentration–time profiles after first dose under multiple-dose conditions analysed using a compartmental approach. The...
The redox properties and GMP-binding of antitumor Ru( iii ) complexes were studied by capillary electrophoresis, NMR spectroscopy square wave voltammetry with regard to the activation such compounds in tumor tissue.
Imidazolium [trans-tetrachloro(1H-imidazole)(S-dimethylsulfoxide)ruthenate(III)] (NAMI-A) and indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) are the most promising ruthenium complexes for anticancer chemotherapy. In this study, azole ligand of NAMI-A was systematically varied (from imidazole to indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, 1-methyl-1,2,4-triazole), respective were evaluated with regard rate aquation protein binding, redox potentials, cytotoxicity...
Indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) shows particular promise as an antitumour agent against colorectal cancer. It is known that KP1019 reacts with human serum proteins, whereby the major amount binds to albumin (present in large excess) and a smaller transferrin. has been hypothesised transferrin-mediated uptake by transferrin receptor expressing tumour cells may part explain apparent selectivity of this compound. Circular dichroism spectroscopy electrospray...
The interaction of two ruthenium(III) complexes exhibiting high anticancer activity, namely trans-indazolium(bisindazole)tetrachlororuthenate(III) (ru-ind) and trans-imidazolium(bisimidazole)tetrachlororuthenate(III) (ru-im), with human serum apotransferrin has been investigated through spectroscopic chromatographic techniques the ultimate goal preparing adducts good selectivity for cancer cells. Whereas binding ru-im to takes several hours, ru-ind, less toxic complex, gives rise a well...
Water-soluble dinuclear Ru−arene complexes were synthesized and found to exert promising cytotoxic effects in human cancer cells, which could be increased an IC50 of 0.29 μM by increasing the spacer length between metal centers. Cytotoxicity correlated with lipophilicity (log P values) water solubility. The most potent compound, 1,12-bis{chlorido[3-(oxo-κO)-2-methyl-4-pyridinonato-κO4](η6-p-isopropyltoluene)ruthenium}dodecane, is at least 2−3 orders magnitude more active than mononuclear...