A5031302291- Wound Healing and Treatments
- Burn Injury Management and Outcomes
- Pressure Ulcer Prevention and Management
- Disaster Response and Management
- Trauma and Emergency Care Studies
- Dermatologic Treatments and Research
- Injury Epidemiology and Prevention
- Surgical Sutures and Adhesives
- Reconstructive Surgery and Microvascular Techniques
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Electrospun Nanofibers in Biomedical Applications
- Diabetic Foot Ulcer Assessment and Management
- Acute Kidney Injury Research
- Diabetes Management and Research
- Poisoning and overdose treatments
- Nonmelanoma Skin Cancer Studies
- Genital Health and Disease
- Laser Applications in Dentistry and Medicine
- Antimicrobial Resistance in Staphylococcus
- Muscle and Compartmental Disorders
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Planarian Biology and Electrostimulation
- Clinical Nutrition and Gastroenterology
Louisiana State University Health Sciences Center New Orleans
2019-2025
University Medical Center New Orleans
2022-2024
University of New Orleans
2020-2024
University of Tennessee Health Science Center
2015-2024
University Medical Center
2024
University Hospital and Clinics
2024
University of North Carolina at Chapel Hill
2024
Duke University
1990-2024
American Burn Association
2008-2024
Medical University of South Carolina
2021-2023
Abstract The safety and effectiveness of Integra® Dermal Regeneration Template was evaluated in a postapproval study involving 216 burn injury patients who were treated at 13 care facilities the United States. mean total body surface area burned 36.5% (range, 1–95%). applied to fresh, clean, surgically excised wounds. Within 2 3 weeks, dermal layer regenerated, thin epidermal autograft placed. incidence invasive infection Integra®-treated sites 3.1% (95% confidence interval, 2.0–4.5%) that...
Analysis of a staged management scheme for initial and definitive acute abdominal wall defects is provided.A four-staged managing consists the following stages: stage I--prosthetic insertion; II--2 to 3 weeks after prosthetic insertion wound granulation, prosthesis removed; III--2 days later, planned ventral hernia (split thickness skin graft [STSG] or full-thickness subcutaneous fat); IV--6 12 months reconstruction. Cases were evaluated retrospectively benefits risks techniques...
Journal Article Summary of the 2012 ABA Burn Quality Consensus Conference Get access Nicole S. Gibran, MD, FACS, FACS Search for other works by this author on: Oxford Academic Google Scholar Shelley Wiechman, PhD, ABPP, ABPP Walter Meyer, MD Linda Edelman, RN, PhD Jim Fauerbach, Gibbons, MS, MS Radha Holavanahalli, Carly Hunt, MA, MA Kelly Keller, RN Elizabeth Kirk, MSN, APN, APN ... Show more Jacqueline Laird, BSN, Giavonni Lewis, Sidonie Moses, BSN Jill Sproul, Gretta Wilkinson, Steve...
Early excision and autografting are standard care for deeper burns. However, donor sites a source of significant morbidity. To address this, the ReCell® Autologous Cell Harvesting Device (ReCell) was designed use at point-of-care to prepare noncultured, autologous skin cell suspension (ASCS) capable epidermal regeneration using minimal skin. A prospective study conducted evaluate clinical performance ReCell vs meshed split-thickness grafts (STSG, Control) treatment deep partial-thickness...
This multicenter study compared the use of a biosynthetic human skin substitute with frozen cadaver allograft for temporary closure excised burn wounds. Dermagraft-TC (Advanced Tissue Sciences, Inc.) (DG-TC) consists synthetic material onto which neonatal fibroblasts are cultured. Burn wounds in 66 patients mean age 36 years and size 44% total body surface area (28% full-thickness) were surgically excised. Two comparable sites, each approximately 1% size, randomized to receive either DG-TC...
Many controversial issues exist surrounding the disease pathogenesis and optimal management of Fournier's gangrene. In original descriptions, arose in healthy subjects without an obvious cause. Most contemporary studies, however, are able to identify definite urologic or colorectal etiologies a majority cases. To investigate presentation, treatment modalities, overall mortality, retrospective analysis gangrene from single institution is presented. Since 1990, 26 cases have been diagnosed at...
Cultured epithelial autografts transplanted to homograft dermis were analyzed histopathologically from 9 days 2.25 years after grafting and compared with cultured wound beds devoid of in the same patient. The results suggested that a dermal substrate accelerates biologic events skin regeneration autografts. Both rete ridge development normalization epidermal keratin program "hyperproliferative" normal pattern occurred months sooner placed on matrix. Regeneration anchoring fibrils was also...
Sepsis and septic shock occur commonly in severe burns. Acute kidney injury (AKI) is also common often results as a consequence of sepsis. Mortality unacceptably high burn patients who develop AKI requiring renal replacement therapy presumed to be even higher when combined with shock. We hypothesized that high-volume hemofiltration (HVHF) blood purification technique would beneficial this population. conducted multicenter, prospective, randomized, controlled clinical trial evaluate the...
Split-thickness skin grafts (STSG) are the standard of care (SOC) for burns undergoing autografting but associated with donor site morbidity and limited by availability uninjured skin. The RECELL® Autologous Cell Harvesting Device (RECELL® System, or RECELL) was developed point-of-care preparation application a suspension non-cultured, disaggregated, autologous cells, using 1cm2 patient's to treat up 80cm2 excised burn.A multi-center, prospective, within-subject controlled, randomized,...
When introducing a new intervention into burn care, it is important to consider both clinical and economic impacts, as the financial burden of burns in USA significant. This study utilizes health modeling approach estimate cost-effectiveness center budget-impact for use RECELL® Autologous Cell Harvesting Device prepare autologous skin cell suspension (ASCS) compared standard care (SOC) split-thickness graft (STSG) treatment severe injuries requiring surgical definitive closure.A...
Existing burn center referral criteria were developed several years ago, and subsequent innovations in care have occurred. Coupled with frequent errors the estimation of extent injury depth by referring providers, patients are both over under-triaged when existing used to support patient decisions. In absence compelling clinical trial data on appropriate triage, we convened a multidisciplinary panel experts execute an iterative eDelphi consensus process facilitate revision. The consisted n =...
The objective of the present study was to compare mechanical, kinetic, and biochemical properties fibrin clots produced using EVICEL Fibrin Sealant (Human) TISSEEL Sealant. stiffness/elasticity strength formed with were assessed applied mechanical force thromboelastography (TEG). factor XIII content also evaluated. Mean Young modulus tensile by significantly higher than those (P < 0.05 for both). mean time initial clot formation predefined level numerically shorter compared TISSEEL....
Burn injury introduces unique clinical challenges that make it difficult to extrapolate mechanical ventilator (MV) practices designed for the management of general critical care patients burn population. We hypothesize no consensus exists among North American centers with regard optimal practices. The purpose this study is examine various MV practice patterns in population and identify potential opportunities future research. A researcher designed, 24-item survey was sent electronically 129...
Acute kidney injury (AKI) after severe burns is historically associated with a high mortality. Over the past two decades, various modes of renal replacement therapy (RRT) have been used in this population. The purpose multicenter study was to evaluate demographic, treatment, and outcomes data among burn patients treated RRT collectively at centers around United States. After institutional review board approval, observational conducted. All adult aged 18 or older, admitted who were placed on...
The goal of this study was to inform standards best practice in the use cultured epidermal autograft (CEA), manufactured United States, for treatment patients with severe burns. designed using modified Delphi technique, a method structuring group communication among experts promote development consensus-based recommendations. Known areas variability related stages CEA were identified by literature review prior and confirmed through qualitative interview experts. included Preoperative...
This report summarizes the characteristics of 954 burned patients treated with cultured epidermal autografts (CEA), largest number to date. Data collected include patient demographics, survival, and final graft take. Source data were provided by treating physician or attending burn team. Safety physician, team, pharmacovigilance database. In this dataset between 1989 2015, autographs for burns. Three hundred twenty-five (34%) pediatric 628 (66%) adult (≥22 years age); age unknown one...
Abstract Since 1970 surgeons have managed deep burns by surgical debridement and autografting. We tested the hypothesis that enzymatic with NexoBrid would remove eschar reducing surgery achieve comparable long-term outcomes as standard of care (SOC). In this Phase 3 trial, we randomly assigned adults (covering 3–30% total body surface area [TBSA]) to NexoBrid, or nonsurgical SOC, placebo Gel Vehicle (GV) in a 3:3:1 ratio. The primary endpoint was complete removal (ER) at end phase. Secondary...