A5109555128- Burn Injury Management and Outcomes
- Wound Healing and Treatments
- Injury Epidemiology and Prevention
- Thermoregulation and physiological responses
- Reconstructive Surgery and Microvascular Techniques
- Disaster Response and Management
- Cardiac Arrest and Resuscitation
- Traumatic Ocular and Foreign Body Injuries
- Restraint-Related Deaths
- Trauma and Emergency Care Studies
- Thermal Regulation in Medicine
- Infrared Thermography in Medicine
- Respiratory Support and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Airway Management and Intubation Techniques
- Trauma Management and Diagnosis
- Geology and Paleoclimatology Research
- Pressure Ulcer Prevention and Management
- Bat Biology and Ecology Studies
- Wildlife Ecology and Conservation
- Climate Change and Health Impacts
- Abdominal Surgery and Complications
- Antimicrobial Resistance in Staphylococcus
- Surgical Sutures and Adhesives
- Animal Ecology and Behavior Studies
Pain Relief Foundation
2025
University of Arkansas at Monticello
2014-2023
King's College Hospital
2017-2022
Princess Royal Hospital
2014
The University of Texas Southwestern Medical Center
2003-2013
Southwestern Medical Center
1978-2012
University of North Texas
2012
University of North Texas Health Science Center
2012
Parkland Memorial Hospital
1988-2011
The University of Texas at Austin
2011
This communication presents an 11-center prospective randomized trial using the artificial dermis invented by Burke and Yannas. Patients with life-threatening burns who underwent primary excision grafting within 7 days of injury had comparable sites to receive either (study site) or investigator's usual skin material (control site). Control materials were autograft, allograft, xenograft, a synthetic dressing. Epidermal grafts applied study site during second operation, surviving patients...
Linezolid, the first available member of a new antibiotic class, oxazolidinones, is broadly active against gram-positive bacteria, including drug-resistant strains. In this randomized, open-label trial, hospitalized adults with known or suspected methicillin-resistant Staphylococcus aureus (MRSA) infections were treated linezolid (600 mg twice daily; n = 240) vancomycin (1 g 220) for 7–28 days. S. was isolated from 53% patients; 93% these isolates MRSA. Skin and soft-tissue infection most...
A multicenter clinical study assessed the ability of an acellular allograft dermal matrix to function as a permanent transplant in full-thickness and deep partial-thickness burns. The consisted pilot phase (24 patients) identify optimum protocol (43 evaluate graft performance. Each patient had both test mirror-image or contiguous control site. At site, was grafted excised wound base split-thickness autograft simultaneously applied over it. site with alone. Fourteen-day take rates were...
Sepsis and organ dysfunction are common likely contribute to death after burn trauma. We sought define relationships between sepsis, severe multiple (MOD), trauma.Adults with > or = 20% total body surface area burns were prospectively enrolled. Information regarding infection, severity of failure was collected daily. Risk factors (e.g., age, size, shock) analyzed for their association MOD, complicated death. characterized the temporal relationship sepsis.Of 175 patients, 27% developed 17%...
Severe burns induce pathophysiologic problems, among them catabolism of lean mass, leading to protracted hospitalization and prolonged recovery. Oxandrolone is an anabolic agent shown decrease mass improve wound healing in the severely burned patients. We enrolled 81 adult subjects with 20% 60% TBSA a multicenter trial testing effects oxandrolone on length hospital stay. Subjects were randomized between 10 mg every 12 hours or placebo. The study was stopped halfway through projected...
Results of the present investigation indicate that an electric burn is simply a thermal injury. The tissue damage associated with injury occurs when energy converted to or heat. An self limiting: once current arcs, no further skin and muscle possible because amperage falls zero. Tissue temperature critical factor in determining magnitude before arcs. With exception resistance, resistances individual tissues seem not relevant amount injuries. Living acts as volume conductor; resistance has...
Fiberoptic bronchoscopy proved to be a simple, safe, and accurate method of diagnosing acute inhalation injury. Both the anatomic level severity large airway injury were easily identified. The identification supraglottic infraglottic component was not only helpful in determining appropriate therapy but also predicting ultimate pulmonary complications. When used conjunction with 133Xenon scintiphotoscan, both small injuries could clinical situation where failed identify an immediate postburn...
A 6.9 million-feature oligonucleotide array of the human transcriptome [Glue Grant (GG-H array)] has been developed for high-throughput and cost-effective analyses in clinical studies. This allows comprehensive examination gene expression genome-wide identification alternative splicing as well detection coding SNPs noncoding transcripts. The performance was examined compared with mRNA sequencing (RNA-Seq) results over multiple independent replicates liver muscle samples. Compared RNA-Seq 46...
This multicenter study compared the use of a biosynthetic human skin substitute with frozen cadaver allograft for temporary closure excised burn wounds. Dermagraft-TC (Advanced Tissue Sciences, Inc.) (DG-TC) consists synthetic material onto which neonatal fibroblasts are cultured. Burn wounds in 66 patients mean age 36 years and size 44% total body surface area (28% full-thickness) were surgically excised. Two comparable sites, each approximately 1% size, randomized to receive either DG-TC...
<b>Context:</b> Sepsis, organ failure, and shock remain common among patients with moderate to severe burn injuries. The inability of clinical factors identify at-risk suggests that genetic variation may influence the risk for serious infection outcome from injury. <b>Objective:</b> Resolution variants associated sepsis following <b>Patients:</b> A total 159 burns ⩾20% their body surface area or any smoke inhalation injury without significant non-burn related trauma (injury severity score...
The formation of an epidermoid carcinoma in nonhealing scar tissue, a Marjolin's ulcer, is well described neoplasm. These lesions are, however, frequently overlooked and often inadequately treated. This paper reviews six cases scar-tissue carcinoma. All were secondary to various kinds burns. Four the ulcers well-differentiated squamous cell carcinomas. One was moderately differentiated carcinoma, one malignant melanoma. average age at presentation 59 years, mean interval from time burn...
Although general awareness of child abuse is increasing, by burning often unrecognized. Seventy-one consecutive children admitted with inflicted burns were studied. Mean age was 1.8 yrs and mean burn size 13.5%. length stay 18.9 days. Scalds (83% from tap water) the most frequent cause injury. An immersion pattern present in 59%; six patients had a classic forced Fourteen nonburn trauma. Four died: all water burns. Inflicted are usually manifested characteristic patterns injury, which must...
HUNT, JOHN L. M.D., MAJOR, MC; McMANUS, WILLIAM F. LIEUTENANT COLONEL, HANEY, WALTER P. PRUITT, BASIL A. JR. MC Author Information
Controversy has continued regarding the practicality and accuracy of Parkland burn formula since its introduction over 35 years ago. The best guide for adequacy resuscitation is urine output (UOP) per hour. A retrospective study patients resuscitated with was conducted to determine (calculated vs. actual volume) based on UOP. review from a single institution 15 conducted. defined as fluid 3.7 4.3 ml/kg/% total body surface area (TBSA) in first 24 hours. Adequate UOP 0.5 1.0 ml/kg/hr....
Background Organ dysfunction and sepsis are frequent after major burn trauma, represent quantifiable consequences of the systemic response to injury, may be important end points by which measure treatment effectiveness. However, standard widely applied methods for their measurement have not been trauma victims. Therefore, purpose this study was quantify these complications trauma. Methods Patients with ≥20% total body surface area burns admitted a single center were prospectively enrolled....
Monitoring genome-wide, cell-specific responses to human disease, although challenging, holds great promise for the future of medicine. Patients with injuries severe enough develop multiple organ dysfunction syndrome have immune derangements, including T cell apoptosis and anergy combined depressed monocyte antigen presentation. Genome-wide expression analysis highly enriched circulating leukocyte subpopulations, pathway analyses, offers an opportunity discover regulatory networks in...
It has been common practice to perform routine electrocardiographic (EKG) monitoring of electrically burned patients for the first 24 hours following injury. Is this necessary, or is it a luxury based on remote probabilities? The records 48 consecutive admitted with high-voltage (greater than 1,000 volts) electrical injuries were reviewed respect history cardiac event in field, EKG abnormalities admission, and presence arrhythmias during postinjury day. No serious occurred any who had normal...
To analyze allelic association with clinical outcome in a cohort of burn patients.Two hundred twenty-eight individuals burns > or =15% total body surface area without significant non-burn related trauma who survived >48 hours post-admission were enrolled. One fifty-nine these patients analyzed previously.Candidate polymorphisms within interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), cellular differentiation marker 14 (CD14) and toll-like receptor...
A review of 102 cases high-voltage electric injuries was performed. The average total body surface area 15.2%. age 32 years. mortality 2.1%. Advances in fluid therapy have virtually eliminated renal failure. Devitalized muscle accurately identified preoperatively with the use technetium Tc 99m pyrophosphate scan. Septic complications were reduced substantially by using following therapeutic modalities: early excision burn eschar and necrotic muscle; quantitative wound biopsies to monitor...