Daniel Herr
A5039559546- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Electron and X-Ray Spectroscopy Techniques
- Respiratory Support and Mechanisms
- Semiconductor materials and devices
- Intensive Care Unit Cognitive Disorders
- Cardiac Structural Anomalies and Repair
- Integrated Circuits and Semiconductor Failure Analysis
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Advancements in Photolithography Techniques
- Ion-surface interactions and analysis
- Copper Interconnects and Reliability
- COVID-19 Clinical Research Studies
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Force Microscopy Techniques and Applications
- Hemodynamic Monitoring and Therapy
- SARS-CoV-2 and COVID-19 Research
- Silicon and Solar Cell Technologies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Surface Roughness and Optical Measurements
- Sepsis Diagnosis and Treatment
- Central Venous Catheters and Hemodialysis
University of Maryland, Baltimore
2016-2025
E Ink (South Korea)
2025
Novem (Netherlands)
2025
Erasmus University Rotterdam
2024
Erasmus MC
2024
Hôpital Louis Pradel
2024
NewYork–Presbyterian Hospital
2023
Columbia University
2023
University of Baltimore
2022
University of Maryland Medical Center
2012-2021
4][5][6] Because delirium is an independent risk factor for prolonged length of stay, greater neuropsychological dysfunction, and increased mortality, 7-10 efforts must be made to reduce this manifestation organ dysfunction within the context providing adequate sedation patients.Lorazepam currently recommended by Society Critical Care Medicine (SCCM) in its clinical prac-tice guidelines 1 sustained mechanically ventilated ICU patients.Although recent trials have shown that protocols with...
Despite signs of infection—including taste loss, dry mouth and mucosal lesions such as ulcerations, enanthema macules—the involvement the oral cavity in coronavirus disease 2019 (COVID-19) is poorly understood. To address this, we generated analyzed two single-cell RNA sequencing datasets human minor salivary glands gingiva (9 samples, 13,824 cells), identifying 50 cell clusters. Using integrated normalization annotation, classified 34 unique subpopulations between gingiva. Severe acute...
Object. A randomized double-blind clinical trial was conducted to compare neurological and functional recovery morbidity mortality rates 1 year after acute spinal cord injury in patients who had received a standard 24-hour methylprednisolone regimen (24MP) with those whom an identical MP been delivered for 48 hours (48MP) or 48-hour tirilazad mesylate (48TM) regimen. Methods. Patients treatment initiated within 3 of showed equal all three groups. delayed more than experienced diminished...
Linezolid, the first available member of a new antibiotic class, oxazolidinones, is broadly active against gram-positive bacteria, including drug-resistant strains. In this randomized, open-label trial, hospitalized adults with known or suspected methicillin-resistant Staphylococcus aureus (MRSA) infections were treated linezolid (600 mg twice daily; n = 240) vancomycin (1 g 220) for 7–28 days. S. was isolated from 53% patients; 93% these isolates MRSA. Skin and soft-tissue infection most...
Abstract Introduction Benzodiazepines and α 2 adrenoceptor agonists exert opposing effects on innate immunity mortality in animal models of infection. We hypothesized that sedation with dexmedetomidine (an agonist), as compared lorazepam (a benzodiazepine), would provide greater improvements clinical outcomes among septic patients than non-septic patients. Methods In this a priori -determined subgroup analysis vs from the MENDS double-blind randomized controlled trial, adult medical/surgical...
This document was developed through the collaborative efforts of Society Critical Care Medicine, American College Chest Physicians, and Association Organ Procurement Organizations. Under auspices these societies, a multidisciplinary, multi-institutional task force convened, incorporating expertise in critical care medicine, organ donor management, transplantation. Members were divided into 13 subcommittees, each focused on one following general or organ-specific areas: death determination...
BACKGROUND: Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk in critically ill patients. To our knowledge, no studies have evaluated whether aspirin use reduced of mechanical ventilation, intensive care unit (ICU) admission, in-hospital mortality. METHODS: A retrospective, observational cohort study adult patients admitted COVID-19 to multiple hospitals the United States between March 2020 July was performed. The primary outcome need for...
Rationale: Current practices regarding mechanical ventilation in patients treated with extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome are unknown.Objectives: To report current ECMO severe (ARDS) and their association 6-month outcomes.Methods: This was an international, multicenter, prospective cohort study of undergoing ARDS during a 1-year period 23 international ICUs.Measurements Main Results: We collected demographics, daily pre- per-ECMO settings use...
Abstract COVID-19 is known to cause multi-organ dysfunction 1-3 in acute infection, with prolonged symptoms experienced by some patients, termed Post-Acute Sequelae of SARS-CoV-2 (PASC) 4-5 . However, the burden infection outside respiratory tract and time viral clearance not well characterized, particularly brain 3,6-14 We performed complete autopsies on 44 patients map quantify distribution, replication, cell-type specificity across human body, including brain, from through over seven...
Object. Sedation regimens for head-injured patients are quite variable. The short-acting sedative—anesthetic agent propofol is being increasingly used in such patients, yet little known regarding its safety and efficacy. In this multicenter double-blind trial, a titratable infusion of 2% accompanied by low-dose morphine analgesia was compared with regimen sulfate intubated patients. both groups, other standard measures controlling intracranial pressure (ICP) were also used. Methods....
Catheter-related bloodstream infection (CRBSI) causes substantial morbidity and mortality, but few randomized, controlled studies have been conducted to guide therapeutic interventions.To determine whether linezolid would be noninferior vancomycin in patients with CRBSI, we an open-label, multicenter, comparative study. Patients suspected CRBSI were randomized receive or (control group). The primary end point was microbiologic outcome at test of cure 1-2 weeks after treatment, as assessed by...
To revise the "Clinical Practice Guidelines for Sustained Use of Sedatives and Analgesics in Critically Ill Adult" published Critical Care Medicine 2002. The American College assembled a 20-person, multidisciplinary, multi-institutional task force with expertise guideline development, pain, agitation sedation, delirium management, associated outcomes adult critically ill patients. force, divided into four subcommittees, collaborated over six years person, via teleconferences, electronic...
Following acute respiratory distress syndrome (ARDS), joblessness is common but poorly understood.
To examine the feasibility and safety of mobilizing patients while on extracorporeal membranous oxygenation support.Retrospective cohort study.Medical Surgical ICUs in a large tertiary care hospital United States.Adults supported from January 2014 to December 2015.We reviewed medical records physical therapy, perfusion, intensivists obtain number type therapy interventions discharge status; description support, cannulation sites; risk management details adverse effects, if any. Of 254...
Background Extracorporeal membrane oxygenation (ECMO) has been increasingly used for postcardiotomy cardiogenic shock, but without a concomitant reduction in observed in-hospital mortality. Long-term outcomes are unknown. This study describes patients' characteristics, outcome, and 10-year survival after ECMO. Variables associated with postdischarge mortality investigated reported. Methods Results The retrospective international multicenter observational PELS-1 (Postcardiotomy Life Support)...
<h3>Objectives</h3>To evaluate the safety and tolerability of treatment with levetiracetam determine trough levels in patients traumatic brain injury (TBI) who are at high risk for posttraumatic epilepsy (PTE).<h3>Design</h3>Open-label, nonrandomized phase 2 study arms comparing vs observation.<h3>Setting</h3>Two level 1 trauma centers.<h3>Patients</h3>A total 422 participants 6 years or older TBI have a 20% PTE were screened. Of these participants, 205 (48.6%) eligible. A 126 enrolled: 86...
Limited literature regarding the incidence of cannula-associated deep vein thrombosis (CaDVT) after veno-venous extracorporeal membrane oxygenation (VV ECMO) exists. The purpose this study was to identify post decannulation CaDVT and any associated risk factors. Forty-eight patients were admitted between August 2014 January 2016 Lung Rescue Unit included in study. Protocolized anticoagulation levels (partial thromboplastin time [PTT] 45–55 seconds) routine DVT screening place during period....