A5035661421- Burn Injury Management and Outcomes
- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Injury Epidemiology and Prevention
- Disaster Response and Management
- Thermal Regulation in Medicine
- Immune Response and Inflammation
- Airway Management and Intubation Techniques
- Reconstructive Surgery and Microvascular Techniques
- Smoking Behavior and Cessation
- Cardiac Arrest and Resuscitation
- Traumatic Ocular and Foreign Body Injuries
- Electrospun Nanofibers in Biomedical Applications
- Nosocomial Infections in ICU
- Restraint-Related Deaths
- Telemedicine and Telehealth Implementation
- Immune cells in cancer
- Diabetic Foot Ulcer Assessment and Management
- Phagocytosis and Immune Regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pressure Ulcer Prevention and Management
- COVID-19 and healthcare impacts
- Single-cell and spatial transcriptomics
- Intensive Care Unit Cognitive Disorders
- Laser Applications in Dentistry and Medicine
Massachusetts General Hospital
2016-2025
Harvard University
2014-2025
Shriners Hospitals for Children - Boston
2006-2025
Spaulding Rehabilitation Hospital
2024
Boston University
2024
Columbia St. Mary's Hospital
2021
University of Iowa Hospitals and Clinics
2021
Stony Brook University
2021
Lehigh Valley Health Network
2020
University of Tennessee Health Science Center
2020
Background: Management of intestinal fistulae in open abdominal wounds remains a significant clinical challenge for those caring patients surviving damage control operations. Breaking the cycle tissue inflammation, infection, and sepsis, resulting from leakage enteric contents, should be major goal approach to these complex patients. We describe technique utilizing vacuum assisted closure (VAC) which achieves flow wounds. Methods: The fistula-VAC is fashioned standard sponge supplies,...
This article presents a small case series demonstrating clinical success with thrombolytic agents for severe frostbite injury to the lower extremities. The authors report three patients injuries their distal extremities who were managed urgent interventional radiology and intra-arterial tissue plasminogen activator infusion according prespecified protocol. Limbs digits successfully salvaged returned normal activity within 2 weeks. Although further studies are needed, results of this study...
Full-thickness skin loss is a challenging problem due to limited reconstructive options, demanding 75 million surgical procedures annually in the United States. Autologous grafting gold standard treatment, but results donor-site morbidity and poor aesthetics. Numerous substitutes are available on market date, however, none truly functions as full-thickness lack of vascular network. The creation an autologous analogue with pedicle would result paradigm shift management wounds reconstruction...
Voltage has historically guided the acute management and long-term prognosis of physical morbidity in electrical injury patients; however, few large studies exist that include neuropsychiatric final outcome analysis. This review compares high (>1000 V) to low (<1000 voltage injuries, focusing on return work sequelae following burn injury. Patients with injuries admitted University North Carolina Jaycee Burn Center between 2000 2005 were prospectively entered into a trauma database, then...
Objectives: ABRUPT was a prospective, noninterventional, observational study of resuscitation practices at 21 burn centers. The primary goal to examine with albumin or crystalloids alone, design future prospective randomized trial. Summary Background Data: No modern has determined whether use colloids for acute resuscitation. Methods: Patients ≥18 years burns ≥ 20% total body surface area (TBSA) had hourly documentation parameters 48 hours. received either alone supplemented crystalloid...
Abstract Circulating monocytes contribute to the defense against pathogens and play a crucial role in maintaining immune homeostasis. While there is substantial evidence regarding triggers of monocyte activation, our understanding how function restored toward homeostasis after activation remains limited. Here, we assessed changes anisocytosis upon blood, measured by distribution width (MDW), biomarker for sepsis. We determined that increase MDW post‐lipopolysaccharide (LPS) stimulation blood...
Abstract Introduction Universal screening for acute stress disorder (ASD) is recommended by the American Burn Association (ABA) but can be challenging to implement in U.S. burn centers due lack of resources and visit time constraints. Recent studies have shown prevalence ASD patients range from 1% up 30%. We aimed formalize our process a way that allowed privately self-survey during their visit. Methods By working with burn-specific psychiatrist patient- led questionnaire assessing...
Abstract Introduction Burn injuries trigger pathological immune responses. However, our ability to monitor these evolving responses is constrained by the intricate confluence of cellular, biochemical, and metabolic alterations that occur concurrently post-injury. In this study, we concentrate on monocytes, which serve as key mediators burn-induced changes potential biomarkers for monitoring after injury. Methods We enrolled adult pediatric patients with major burn (&gt;15%) collected...
Abstract Introduction Excision and autografting are frequently staged to allow time for an increase in wound bed vascularity via formation of granulation tissue. Negative pressure therapy (NPWT) skin substitutes used regenerate tissue, stimulate a bed, hasten formation. Intact fish (FS) is xenograft, biologic, substitute reported decrease length stay, minimize prolonged hospitalization, improve resource allocation. We hypothesized that NPWT equally effective creating vascularized with or...
Abstract This pilot study evaluated the feasibility of treating third-degree, full-thickness burn wounds with both split-thickness skin grafts (STSGs) and micro tissue columns (MSTC). Donor sites for grafting techniques were also assessed. Patients aged ≥18 years ≤60% total body surface area (TBSA) burns enrolled. One 2.5 x cm2 wound was treated in each subject, remaining portion used as an internal control. The target MSTCs + STSG while control site STSG. followed up to nine months after...
Split-thickness skin grafting is a useful method of wound repair in burn and reconstructive operations. However, grafts require donor site injury that creates secondary at risk for delayed healing. Though young healthy patients such sites have minimal risk, with factors healing are more challenging. We present graft management offers an alternative to by intention higher poor In those considered be high complications, we chose treat the split-thickness graft, or "graft back" procedure. An...
Telemedicine has been successfully used in many areas of medicine, including triage and evaluation the acute burn patient. The utility telemedicine during rehabilitative phase care yet to be evaluated; therefore, we expanded our program link center with a rehabilitation facility. goal this project was demonstrate cost-effective improvements transition quality care. A retrospective review performed on all patients enrolled telemedicine/rehabilitation between March 2013 2014. Data collected...
Abstract Since 1970 surgeons have managed deep burns by surgical debridement and autografting. We tested the hypothesis that enzymatic with NexoBrid would remove eschar reducing surgery achieve comparable long-term outcomes as standard of care (SOC). In this Phase 3 trial, we randomly assigned adults (covering 3–30% total body surface area [TBSA]) to NexoBrid, or nonsurgical SOC, placebo Gel Vehicle (GV) in a 3:3:1 ratio. The primary endpoint was complete removal (ER) at end phase. Secondary...
Adult intussusception has been described after various types of gastrointestinal surgery. In some instances there may be the jejunum into stomach via a stoma, rare complication known as jejunogastric (JGI). We present retrospective review two cases retrograde occurring years open Roux-en-Y gastric bypass (RYGB) for morbid obesity. To our knowledge have no documented reports JGI RYGB and only scattered reconstruction in general. Two following were identified English literature comprised three...
Amniotic membrane is immunologically privileged and a reservoir of growth factors cytokines known to modulate inflammation enhance the healing process, while also possessing antimicrobial, antifibrosis, antiscarring properties. These properties establish strong argument for using amniotic derived products as treatment burns. The purpose this article describe use commercially available dehydrated human amnion/chorion allografts in patients with partial-thickness full-thickness
Accumulation of secretions may suddenly occlude an endotracheal tube (ETT), requiring immediate medical attention. The endOclear catheter (Endoclear LLC, Petoskey, Michigan) is a novel device designed to clear mucus and debris from ETT restore luminal patency. We present 3 subsequent cases life-threatening partial occlusions recorded over period 6 months at Massachusetts General Hospital. After conventional methods (standard tracheal suctioning bronchoscopy) failed, the was used, with...