A5013408079- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- MRI in cancer diagnosis
- Radiation Dose and Imaging
- Radiology practices and education
- COVID-19 and healthcare impacts
- Abdominal vascular conditions and treatments
- Ureteral procedures and complications
- Ultrasound and Hyperthermia Applications
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Treatments and Studies
- Renal and Vascular Pathologies
- Venous Thromboembolism Diagnosis and Management
- RNA Interference and Gene Delivery
- Infectious Aortic and Vascular Conditions
- Advanced X-ray and CT Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Osteoarthritis Treatment and Mechanisms
- Vascular anomalies and interventions
- Photoacoustic and Ultrasonic Imaging
- Peripheral Artery Disease Management
- Gastrointestinal disorders and treatments
- Prostate Cancer Treatment and Research
- Central Venous Catheters and Hemodialysis
University Hospitals of Cleveland
2016-2024
Case Western Reserve University
2016-2024
Kent State University
2024
Oregon Health & Science University
2022-2023
University School
2016-2021
Università Campus Bio-Medico
2021
University Hospitals Cleveland Medical Center
2019
University of California, San Diego
2010-2015
University of San Diego
2012
Stanford University
2012
To assess the capability of folate receptor (FR)-targeted ultrasmall superparamagnetic iron oxide (USPIO) P1133 to provide FR-specific enhancement breast cancers on magnetic resonance (MR) images.This study was approved by institutional Animal Care and Use Committee. The FR-targeted contrast agent incubated with various FR-positive human cancer cell lines, without free folic acid (FFA) as a competitor. Labeling efficiencies were evaluated MR imaging inductively coupled plasma mass...
The purpose of this study was to track fluorophore-labeled, tumor-targeted natural killer (NK) cells human prostate cancer xenografts with optical imaging (OI). NK-92-scFv(MOC31)-zeta targeted the epithelial cell adhesion molecule (EpCAM) antigen on and nontargeted NK-92 parental were labeled near-infrared dye DiD (1,1'-dioctadecyl-3,3,3',3'-tetramethylindodicarbocyanine). fluorescence, viability, cytotoxicity evaluated. Subsequently, 12 athymic rats underwent OI scans before up 24 hours...
The purpose of this study was to (1) compare three different techniques for ferumoxide labeling mesenchymal stem cells (MSCs), (2) evaluate if allows in vivo tracking matrix-associated cell implants (MASIs) an animal model, and (3) the magnetic resonance imaging (MRI) characteristics ferumoxide-labeled viable apoptotic MSCs. MSCs labeled with by simple incubation, protamine transfection, or Lipofectin transfection were evaluated MRI histopathology. Ferumoxide-labeled unlabeled osteochondral...
Abstract Genetically modified natural killer (NK) cells that recognize tumor‐associated surface antigens have recently shown promise as a novel approach for cancer immunotherapy. To determine NK cell therapy response early, real‐time, noninvasive method to quantify homing the tumor is desirable. The purpose of this study was evaluate if MR imaging could provide noninvasive, in vivo diagnosis accumulation epithelial adhesion molecule (EpCAM)‐positive prostate cancers rat xenograft model....
Magnetic resonance (MR) imaging of superparamagnetic iron oxide (SPIO)-labeled stem cells offers a noninvasive evaluation cell engraftment in host organs. Excessive cellular load from SPIO labeling, however, impairs differentiation. The purpose this study was to magnetically label human embryonic (hESCs) via reduced exposure protocol that maintains significant MR signal and no impairment pluripotency or differentiation potential. hESCs were labeled by simple incubation with Food Drug...
To determine whether (a) stem cells loaded with DNA-carrying microbubbles (MBs) can be transfected in vivo, (b) the remain alive to express gene, and (c) gene expression is sufficiently robust detected vivo.The study was approved by Institutional Animal Care Use Committee. Cationic MBs were prepared, characterized, pLuciferase green fluorescent protein (GFP) plasmid. Loading confirmed SYBR Gold staining (Life Technologies, Carlsbad, Calif). C17.2 MBs. Two hundred thousand suspended 20 μL...
Abstract Background The development of postoperative granulation tissue is one the main risks after lumbar spine surgery. This may lead to persistent or new clinical symptoms complicate a follow up A sensitive non-invasive imaging technique, that could diagnose this at bedside, would help develop appropriate treatments. Thus, purpose study was establish fast and economic tool for diagnosis surgery, using integrated Optical Imaging (OI)/X-ray system FDA-approved fluorescent contrast agent...
Abstract Background Prostate cancer (PCa) models in mice and rats are limited by their size lack of a clearly delineated or easily accessible prostate gland. The canine PCa model is currently the only large animal which can be used to test new preclinical interventions but costly availability sparse. As an alternative, we developed orthotopic human tumor immunosuppressed New Zealand White rabbit. Rabbits phylogenetically closer humans, gland anatomically similar, its allows for...
Abstract Indocyanine green (ICG) is a contrast agent used for detecting angiogenesis with optical imaging (OI). The purpose of this study was to investigate whether cooling procedures increase the signal yield ICG OI. Test samples 0.05 and 0.02 m M in 40% DMSO 60% DMEM underwent OI at four different temperatures (5, 37, 55 75°C). In addition, six athymic rats an antigen‐induced arthritis knee ankle joints before after injection (10 mg/ml, dose 15 mg/kg) on two separate days without joints....
To evaluate Interventional Radiology (IR) procedural volume changes at a large Midwest health system between March 17, 2020 and April 30, following state-mandated shutdown of nonessential procedures during the initial phase COVID-19.
Peri-tumoral inflammation is a common tumor response that plays central role in invasion and metastasis, inflammatory cell recruitment essential to this process. The purpose of study was determine whether injected fluorescently-labeled monocytes accumulate within murine breast tumors are visible with optical imaging. Murine were labeled the fluorescent dye DiD subsequently intravenously into 6 transgenic MMTV-PymT tumor-bearing mice FVB/n control without tumors. Optical imaging (OI)...
Abstract Congenital extrahepatic portosystemic shunt (CEPS) is a rare splanchnic venous malformation, wherein the portal outflow drains into systemic circulation via pathologic shunt. CEPS exhibits heterogeneous clinical behavior and angiography gold standard for evaluation of portomesenteric communication to vasculature. The potential severity complications necessitates closure. Here, we present two cases CEPS. first patient presented with an asymptomatic hyperammonemia was found have Type...