A5100614311- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Metal complexes synthesis and properties
- Single-cell and spatial transcriptomics
- T-cell and B-cell Immunology
- Computational Drug Discovery Methods
- Extracellular vesicles in disease
- PI3K/AKT/mTOR signaling in cancer
- Plant Virus Research Studies
- Lung Cancer Research Studies
- Medical Research and Treatments
- Cervical Cancer and HPV Research
- HER2/EGFR in Cancer Research
- Molecular Biology Techniques and Applications
- Ferroptosis and cancer prognosis
- Nuclear Receptors and Signaling
- Advanced biosensing and bioanalysis techniques
- Atherosclerosis and Cardiovascular Diseases
- Hedgehog Signaling Pathway Studies
Henan Psychiatric Hospital
2023
Xinxiang Medical University
2023
Second Affiliated Hospital of Xi'an Jiaotong University
2020-2023
Xi'an Jiaotong University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Xinxiang Central Hospital
2020
First Affiliated Hospital of Xi'an Jiaotong University
2018-2020
University of Liverpool
2020
Air Force Medical University
2014-2019
Xijing Hospital
2014-2019
T lymphocytes infiltrate the microenvironment of breast cancer tumors and play a pivotal role in tumor immune surveillance. Relationships between T-cell receptors (TCR) borne by cells within tumors, surrounding tissues, draining lymph nodes are largely unexplored human cancer. Consequently, information about relative extent possible exchange these tissues is also lacking. Here, we have analyzed TCR repertoire using multiplex PCR high-throughput sequencing TCRβ chain tumor, adjacent nontumor,...
// Yuan Sheng 2,* , Ting Wang 1,* Hengyu Li Zhenzhen Zhang 3,* Jianghao Chen Chenyang He 1 Yongping Yonggang Lv Juliang Cheng Xu 3 Zhen 4 Huang 5 and Ling Department of Vascular Endocrine Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China 2 Thyroid Breast Changhai Second Shanghai, Biotecan Diagnostics Co., Ltd, Zhangjiang Center for Translational Medicine, Shanghai,China Orthopedics, Nephrology, * These authors have contributed equally to the work...
The comprehensive recognition of communications between bone marrow mesenchymal stem cells (bm-MSCs) and macrophages in the peri-implant microenvironment is crucial for implantation prognosis. Our previous studies have clarified indirect influence Ti surface topography osteogenic differentiation bm-MSCs through modulating macrophage polarization. However, cell communication commutative multi-directional. As immune regulatory properties MSCs become increasingly prominent, whether could also...
The cancer stem cell (CSC) hypothesis has gained significant recognition in describing tumorigenesis. Identification of the factors critical to development breast cells (BCSCs) may provide insight into improvement effective therapies against cancer. In this study, we aim investigate biological function SLC34A2 affecting cell-like phenotypes BCSCs and its underlying mechanisms. We demonstrated that CD147 + from tissue samples lines possessed BCSC-like features, including ability self-renewal...
Despite an increase in the number of molecular epidemiological studies conducted recent years to evaluate association between human papillomavirus (HPV) and risk breast carcinoma, these remain inconclusive. Here we aim detect HPV DNA various tissues from patients with carcinoma using method capture combined massive paralleled sequencing (MPS). To validate confidence our methods, 15 cervical cancer samples were tested by PCR new method. Results showed that there was 100% consistence two...
Long non-coding RNAs (lncRNAs) have been reported to be vital participants in tumor progression.Recently, lncRNA PSMB8-AS1 has uncovered facilitate pancreatic cancer progression by regulating miR-382-3p/STAT1/PD-L1 network.Nonetheless, the role of and its underlying mechanism not well-explored colorectal (CRC).The expression or proteins was detected via qRT-PCR western blot assays.Functional assays were involved evaluating effects PSMB8-AS1/miR-1299/ADAMTS5 on malignant behaviors CRC...
Background: Cases of multiple tumors are rarely reported in China. In our study, a 57-year-old female patient had concurrent squamous cell carcinoma, mucoepidermoid brain cancer, bone and thyroid which has been to date. Methods: To determine the relationship among these cancers, available DNA samples from thyroid, lung, skin normal tissue were sequenced using whole exome sequencing. Results: The notable discrepancies somatic mutations 3 tumor tissues indicated that they arose independently,...
Lung adenocarcinoma, the most common histological subtype of non-small cell lung cancer, exhibits heterogeneity that enables adaptability, limits therapeutic success, and remains incompletely understood. Our team uncovers lncRNA related to chemotherapy resistance in adenocarcinoma (lncCRLA) is preferentially expressed cells with mesenchymal phenotype. lncCRLA can not enhance due its binding RIPK1 exosomes, which released into intercellular media transferred by exosomes from mesenchymal-like...
Abstract The tumor microenvironment is composed of numerous cell types, including tumor, immune and stromal cells. Cancer cells interact with the to suppress anticancer immunity. In this study, we molecularly dissected breast cancer by single-cell RNA-seq. We profiled analyzing transcriptomes 52,163 from tissues 15 patients. individual patients were analyzed simultaneously at level. This study explores diversity types in provides information on mechanisms escape clearance cancer. One...
This experimental study aims to investigate the role of long noncoding RNA X-inactive specific transcript (lncRNA XIST) in microglial polarization and microglia-mediated neurotoxicity Alzheimer's disease (AD).The levels XIST microRNA-107 (miR-107) were detected by quantitative real-time polymerase chain reaction. The spatial learning memory capability APPswe/PS1dE9 (APP/PS1) mice evaluated Morris water maze test. morphology mouse hippocampus cells was hematoxylin eosin staining....
Protein profiling based on matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) has proved to be a powerful tool for yeast identification. However, it is rarely used in the identification of isolates from polar regions, which may due limited data available differentiation species. The present study constructed supplementary database MALDI-TOF MS, including 33 species Arctic and Antarctica. These were assess accuracy practicality MS-based compared...
c-Src and the epidermal growth factor receptor (EGFR) are key apical kinases that govern cell responses to microenvironmental cues. How affects EGFR-related signaling targeted therapy remains elusive. Initially, caspase-8 phosphorylated at tyrosine 380 by predominantly enhancing activation facilitate metastasis through attaining epithelial-mesenchymal transition (EMT) phenotype in lung adenocarcinoma. Mechanistically, linkage of SH2 domain with phosphotyrosine SH3 “PDEP” motif overactivates...
Abstract Background: Our recent investigation directed to synthesize and characterize a novel ruthenium– phloretin complex accompanied by the study of antioxidant in addition DNA binding capabilities, determine chemotherapeutic activity against breast carcinoma vitro vivo approach. Methods: Ruthenium–phloretin was synthesized characterized using various spectroscopic methods. The further investigated its efficacy both MCF-7 MDA-MB-231 human cancer cell lines finally an model DMBA induced...
To date, anatomic tumor length is a key criterion for cancer staging and can be used to evaluate the effectiveness of therapies. This article describes growth pattern that as new characteristic represent disease burden features predict lymphatic metastasis.Patients with breast were included in this 10-year (1999-2008) hospital-based multicenter retrospective study. The pathologic length/height ratio was illustrate correlation between features, behaviors treatments malignancies. most...
Abstract Background: Our recent investigation directed to synthesize and characterize a novel ruthenium– phloretin complex accompanied by the study of antioxidant in addition DNA binding capabilities, determine chemotherapeutic activity against breast carcinoma vitro vivo approach. Methods: Ruthenium–phloretin was synthesized characterized using various spectroscopic methods. The further investigated its efficacy both MCF-7 MDA-MB-231 human cancer cell lines finally an model DMBA induced...
<div>Abstract<p>T lymphocytes infiltrate the microenvironment of breast cancer tumors and play a pivotal role in tumor immune surveillance. Relationships between T-cell receptors (TCR) borne by T cells within tumors, surrounding tissues, draining lymph nodes are largely unexplored human cancer. Consequently, information about relative extent possible exchange these tissues is also lacking. Here, we have analyzed TCR repertoire using multiplex PCR high-throughput sequencing TCRβ...
<p>Comparison of TRBV or TRBJ segment usage between tumor tissue and other two tissues.</p>
<p>Shared clone frequency between lymph node and tumor tissue in tissue.</p>
<p>The similarity between paired lymph node, non-tumor and tumor tissue.</p>