A5100731286- Cancer-related molecular mechanisms research
- Colorectal Cancer Surgical Treatments
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Liver Disease Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Radiopharmaceutical Chemistry and Applications
- Peptidase Inhibition and Analysis
- Colorectal and Anal Carcinomas
- TGF-β signaling in diseases
- Nanoplatforms for cancer theranostics
- Ubiquitin and proteasome pathways
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
Sun Yat-sen University
2019-2025
Sun Yat-sen University Cancer Center
2019-2025
West China Hospital of Sichuan University
2014-2025
Research Center for Eco-Environmental Sciences
2025
Chinese Academy of Sciences
2011-2025
Sichuan University
2013-2025
The Fourth People's Hospital of Zibo City
2025
Charité - Universitätsmedizin Berlin
2025
Max Delbrück Center
2025
Shanghai Jiao Tong University
2012-2024
AIMTo compare the expression levels of interleukin (IL)-6 in colorectal cancer (CRC) tissues and adjacent noncancerous tissues, analyse correlation IL-6 with clinicopathological parameters CRC. METHODSFifty CRC tissue specimens 50 matched mucosa were collected.The these clinical samples was examined by immunohistochemical staining.The between assessed statistical analysis. RESULTSIL-6 significantly elevated compared (P < 0.001).IL-6 positively correlated tumour TNM stage 0.001), but a...
Abstract Introduction Breast cancer is the leading cause of death in women worldwide. Elevated expression c-Myc a frequent genetic abnormality seen this malignancy. For better understanding its role maintaining malignant phenotype, we used RNA interference (RNAi) directed against our study. RNAi provides new, reliable method to investigate gene function and has potential for therapy. The aim study was examine anti-tumor effects elicited by decrease protein level possible mechanism MCF-7...
Alzheimer's disease (AD) is a chronic progressive neurodegenerative disorder. However, its pathogenetic mechanism still poorly understood. An increasing number of studies have evidenced the important role long noncoding RNAs (lncRNAs) in AD. The aim current study was to investigate effect and molecular lncRNA X-inactive specific transcript (XIST) Bilateral common carotid artery occlusion (2VO) used induce an AD model mice. Hydrogen peroxide (H2 O2 ) N2a cells. XIST, miR-124, BACE1 messenger...
The current study was designed to examine the functional role and mechanism of miR-125a-3p in glioma development. Quantitative RT-PCR used evaluate expression 60 cases different malignant grades. Then, clinic pathologic significance determined combination with prognosis patients. In addition, effects mechanisms on proliferation, apoptosis invasion cells were further investigated. results showed that decreased significantly most samples relative normal brain tissues low-malignant degree....
Osteoporosis (OP), a prevalent public health concern primarily caused by osteoclast-induced bone resorption, requires potential therapeutic interventions. Natural compounds show as therapeutics for postmenopausal OP. Emerging evidence from in vitro osteoclastogenesis assay suggests that aconine (AC) serves an osteoclast differentiation regulator without causing cytotoxicity. However, the vivo functions of AC various OP models need clarification. To address this, we administered...
Summary Skin‐derived precursors (SKPs) are embryonic neural crest‐ or somite‐derived multipotent progenitor cells with properties of dermal stem cells. Although a large number studies deal their differentiation ability and potential applications in tissue damage repair, only few have concentrated on the regulation SKP self‐renewal. Here, we found that after separation from physiological microenvironment, human foreskin‐derived SKPs (hSKPs) quickly senesced lost self‐renewal ability. We...
To investigate the expressional alternation of microRNAs (miRNA) during malignant transformation and development human glioma, we measured miRNA expression profile as well mRNA in normal neural stem cells (hNSCs) glioma (hGSCs). We found 116 up-regulated 62 down-regulated GSCs. On other hand, identified 1,372 down-regulated, 1,501 GSCs compared to those NSCs. then analyzed pathways predicted target genes miRNAs which differ significantly between NSCs using statistical enrichment methods....
This report describes the biologic evaluations of [ 99m Tc(HYNIC-3P-RGD 2 )(tricine)(TPPTS)] ( Tc-3P-RGD : 6-hydrazinonicotinyl; 3P-RGD = PEG 4 -E[PEG -c(RGDfK)] ; 15-amino-4,7,10,13-tetraoxapentadecanoic acid; and TPPTS trisodium triphenylpho-sphine-3,3′,3“-trisulfonate), Tc(HYNIC-3G-RGD Tc-3G-RGD 3G-RGD G 3 -E[G Gly-Gly-Gly), TcO(MAG −3G-RGD ) (MAG mercaptoacetylglycylglycyl) as radiotracers for noninvasive imaging tumor integrin α v β expression in five xenografted tumor-bearing models....
Abstract Background Patients with hepatocellular carcinoma (HCC) and microvascular invasion (mVI) have shown dismal postoperative prognosis; however, whether adjuvant transarterial chemoembolization (TACE) can improve their outcomes remains unclear. Materials Methods We retrospectively identified 549 eligible patients to form the crude cohort adopted propensity score matching method assemble another of 444 similar baseline characteristics. assessed effects TACE by stratified analyses...
Objective: To investigate the influence of apelin on proliferation and apoptosis in rat ovarian granulosa cells (GCs) vitro. Materials Methods: Primary culture SD GCs was cultured with different concentrations 10-8 mol/L, APJ expression inhibited by small RNA interfering (siRNA). Signaling inhibitor LY294002 PI3K/Akt, HIMO intervention, MTT assay flow cytometry were combined to observe cell apoptosis; Western blot used detect signaling protein related apoptosis. Results: Compared control...
Abstract Ovarian cancer (OC) is one of the most common malignant tumors in women. Circular RNAs (circRNAs) can potentially regulate development OC. Therefore, this study investigated role circASXL1 OC progression. Cell functions were assessed by MTT, colony formation, wound healing, and transwell assays. RIP dual luciferase reporter assays confirmed relationship between miR-320d or RACGAP1. MeRIP was utilized to detect m6A levels. Xenograft tumor established for vivo experiments. CircASXL1...
Abstract Objectives We evaluated the effect of riluzole versus placebo added to weekly IM interferon beta‐1a in early multiple sclerosis ( MS ). Methods This is a randomized (1:1), double‐blind, placebo‐controlled trial 50 mg twice daily subjects with onset less than 1 year prior. Trial participation was up 3 years. The primary endpoint change percent brain volume change. Secondary endpoints included changes normalized gray and normal‐appearing white matter volumes, retinal nerve fiber layer...
Infection by carbapenem-resistant Klebsiella pneumoniae (CRKp) hampers the treatment of elderly patients with lower respiratory tract infection (LRTI); however, relevant data respect to characteristics CRKp in LRTIs are limited. In present study, K. isolated from was collected and identified VITEK-MS. VITEK 2 compact used for drug sensitivity test screen CRKps, broth dilution method tigecycline colistin. The resistance genes, virulence serotypes CRKps were detected via polymerase chain...