A5019344153- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Venous Thromboembolism Diagnosis and Management
- Blood groups and transfusion
- Central Venous Catheters and Hemodialysis
- Neutropenia and Cancer Infections
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Lung Cancer Treatments and Mutations
- Sepsis Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Pharmaceutical industry and healthcare
- Natural Compounds in Disease Treatment
- Iron Metabolism and Disorders
- Protein Degradation and Inhibitors
- Global Public Health Policies and Epidemiology
- Trace Elements in Health
- Bacterial Genetics and Biotechnology
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Chronic Disease Management Strategies
- Patient-Provider Communication in Healthcare
The University of Texas MD Anderson Cancer Center
2016-2019
University of Oklahoma Health Sciences Center
2012-2014
University of North Carolina at Chapel Hill
2010
University of Oklahoma
2006
The Escherichia coli iron transporter, FepA, has a globular N terminus that resides within transmembrane beta-barrel formed by its C terminus. We engineered 25 cysteine substitution mutations at different locations in FepA and modified their sulfhydryl side chains with fluorescein maleimide live cells. reactivity of the Cys residues changed, sometimes dramatically, during transport ferric enterobactin, natural ligand FepA. Patterns susceptibility reflected energy- TonB-dependent motion...
Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for patients with multiple myeloma, as it provides graft-versus-myeloma effect alongside myeloma-free graft. Although reduced-intensity conditioning regimens decrease nonrelapse mortality (NRM), there paucity of data regard to the ideal regimen in myeloma. We conducted retrospective comparison 3 different preparative used allo-HCT myeloma at our institution recent clinical trials: busulfan/fludarabine...
Abstract Background Little is known about agreement between patients and physicians on content outcomes of clinical discussions. A common perception may be desirable to optimize decision making care. Objective To determine patient–physician coronary heart disease (CHD) prevention Design Cross‐sectional survey nested within a randomized CHD study. Setting participants University internal medicine clinic; 24 157 patients. Methods Following one clinic visit, we surveyed discussion content,...
The rapid development of clinical next generation sequencing (NGS) and the contemporaneous availability molecular targeted therapies ignited fueled field precision oncology. More recently there has been an explosion immunotherapeutic agents, specifically checkpoint inhibitors: PD-1, PD-L1 CTLA-4 antibodies. These new classes agents have produced durable responses in a variety tumor subtypes.In this review, authors explore role NGS identifying targets for therapy. also expand on future uses...
Background E vans syndrome is a rare condition manifested by combined autoimmune hemolytic anemia ( AIHA ) and thrombocytopenia or neutropenia. It often associated with other disorders, immunodeficiencies, non‐ H odgkin's lymphoma. Case Report We describe patient that may have been related to exposure polyethylene‐based intrauterine contraceptive device IUD ). A 26‐year‐old white female presented severe, symptomatic subsequently developed severe thrombocytopenia. She had refractory course...
Background: Allo-HCT is a potentially curative therapy for patients with multiple myeloma (MM) as it provides graft-versus-myeloma effect alongside myeloma-free graft. However, the higher rate of non-relapse mortality (NRM) and unclear overall survival (OS) benefit has limited use allo-HCT to clinical trials only. Reduced-intensity conditioning regimens provide improved NRM; however, there paucity data regard ideal regimen in MM. Methods: We conducted retrospective comparison three different...