A5034077529- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Graphene and Nanomaterials Applications
- Advanced Photocatalysis Techniques
- Carbon and Quantum Dots Applications
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Boron and Carbon Nanomaterials Research
- Nanoparticles: synthesis and applications
- Bacterial biofilms and quorum sensing
- Immunodeficiency and Autoimmune Disorders
- Medical and Biological Ozone Research
- Biosensors and Analytical Detection
- Gold and Silver Nanoparticles Synthesis and Applications
- Photodynamic Therapy Research Studies
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Advanced Sensor and Energy Harvesting Materials
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Dendrimers and Hyperbranched Polymers
- Surgical Sutures and Adhesives
- Extracellular vesicles in disease
- Hydrogels: synthesis, properties, applications
Beijing University of Chemical Technology
2017-2025
Columbia University
2023
Single-atom catalysts (SACs), as homogeneous catalysts, have been widely explored for chemical catalysis. However, few studies focus on the applications of SACs in enzymatic Herein, we report that a zinc-based zeolitic-imidazolate-framework (ZIF-8)-derived carbon nanomaterial containing atomically dispersed zinc atoms can serve highly efficient single-atom peroxidase mimic. To reveal its structure-activity relationship, structural evolution nanozyme (SAzyme) was systematically investigated....
Abstract Sonodynamic therapy (SDT) can overcome the critical issue of depth‐penetration barrier photo‐triggered therapeutic modalities. However, discovery sonosensitizers with high sonosensitization efficacy and good stability is still a significant challenge. In this study, great potential metal–organic‐framework (MOF)‐derived carbon nanostructure that contains porphyrin‐like metal centers (PMCS) to act as an excellent sonosensitizer identified. Excitingly, superior effect PMCS believed be...
Abstract Nanozymes have attracted extensive interest owing to their high stability, low cost and easy preparation, especially in the field of cancer therapy. However, relatively catalytic activity nanozymes tumor microenvironment (TME) has limited applications. Herein, we report a novel nanozyme (PtFe@Fe 3 O 4 ) with dual enzyme‐like activities for highly efficient PtFe@Fe shows intrinsic photothermal effect as well photo‐enhanced peroxidase‐like catalase‐like acidic TME, thereby effectively...
Abstract Nanozyme‐based tumor catalytic therapy has attracted widespread attention in recent years. However, its therapeutic outcomes are diminished by many factors the microenvironment (TME), such as insufficient endogenous hydrogen peroxide (H 2 O ) concentration, hypoxia, and immunosuppressive microenvironment. Herein, an immunomodulation‐enhanced nanozyme‐based strategy is first proposed to achieve synergism between nanozymes TME regulation. TGF‐β inhibitor (TI)‐loaded PEGylated iron...
Single-atom nanozymes (SAzymes) represent a new research frontier in the biomedical fields. The rational design and controllable synthesis of SAzymes with well-defined electronic geometric structures are essential for maximizing their enzyme-like catalytic activity therapeutic efficacy but remain challenging. Here, melamine-mediated pyrolysis activation strategy is reported fabrication iron-based SAzyme containing five-coordinated structure (FeN5 ), identified by transmission electron...
Pathogenic bacteria pose a devastating threat to public health. However, because of the growing bacterial antibiotic resistance, there is an urgent need develop alternative antibacterial strategies established antibiotics. Herein, iron-doped carbon dots (Fe-CDs, ∼3 nm) nanozymes with excellent photothermal conversion and photoenhanced enzyme-like properties are developed through facile one-pot pyrolysis approach for synergistic efficient therapy wound healing. In particular, Fe doping endows...
Abstract Dual phototherapy, including photodynamic therapy (PDT) and photothermal (PTT), has shown a great prospect in cancer treatment. However, its therapeutic effect is restricted by the depth of light penetration tissue tumor hypoxia environment. Herein, inspired specific response nanozymes to microenvironment (TME), simple versatile nanozyme‐mediated synergistic dual phototherapy nanoplatform (denoted as FePc/HNCSs) constructed using hollow nitrogen‐doped carbon nanospheres (HNCSs) iron...
Pd nanosheets (Pd NSs) have attracted extensive attention due to their promising application in photothermal therapy. However, photodynamic properties rarely been reported. Herein, holey NSs (H-Pd with intrinsic and hypoxia-resistant capacities are fabricated for the first time using an anisotropic oxidative etching strategy, which introduces one-dimensional nanoholes active (100) facets on hole walls. Gradual degradation of H-Pd is observed simulated physiological media etching. In vitro...
Abstract Single‐atom catalysts (SACs), as homogeneous catalysts, have been widely explored for chemical catalysis. However, few studies focus on the applications of SACs in enzymatic Herein, we report that a zinc‐based zeolitic‐imidazolate‐framework (ZIF‐8)‐derived carbon nanomaterial containing atomically dispersed zinc atoms can serve highly efficient single‐atom peroxidase mimic. To reveal its structure–activity relationship, structural evolution nanozyme (SAzyme) was systematically...
Abstract Microneedles (MNs) have attracted widespread scientific and industrial interest in the past decade as an efficient, painless, low‐cost, relatively safe transdermal drug delivery device. However, their drawbacks such insufficient dose accuracy limited penetration depth may limit clinical applications. Here, a light‐controlled liquid band‐aid based on MNs is developed for antibacterial Metal–organic framework‐derived peroxidase‐like nanozyme loaded can not only convert light energy...
Abstract Nanozymes have attracted extensive interest owing to their high stability, low cost and easy preparation, especially in the field of cancer therapy. However, relatively catalytic activity nanozymes tumor microenvironment (TME) has limited applications. Herein, we report a novel nanozyme (PtFe@Fe 3 O 4 ) with dual enzyme‐like activities for highly efficient PtFe@Fe shows intrinsic photothermal effect as well photo‐enhanced peroxidase‐like catalase‐like acidic TME, thereby effectively...
Sonodynamic therapy (SDT) offers an efficient noninvasive strategy for cancer treatment. However, the efficiency of SDT is limited by structural and physicochemical properties ultrasound (US)-sensitive agents. Here, we discover combination bioactivity sonodynamic zeolite imidazolium framework-8 nanocrystals (ZIF-8 NCs) tumor therapy. ZIF-8 NCs are susceptible to biodegradation release zinc ions (Zn2+) triggered weakly acidic microenvironment, demonstrating induce apoptosis in cells. Density...
Palladium nanosheets (Pd NSs) are well-investigated photothermal therapy agents, but their catalytic potential for tumor has been underexplored owing to the inactive dominant (111) facets. Herein, lattice tensile strain is introduced by surface reconstruction activate inert surface, endowing strained Pd NSs (SPd with photodynamic, catalase-like, and peroxidase-like properties. Tensile promoting photodynamic enzyme-like activities revealed density functional theory calculations. Compared NSs,...
Abstract The emergence of multi‐drug resistant (MDR) bacteria poses a serious threat to human health. It has become imperative develop efficient antimicrobial strategies. Here, manganese‐doped dopamine‐derived hollow carbon sphere (MnO x /HNCS) is developed as nanozyme and photothermal agent for the synergistic treatment MDR bacterial infections. MnO /HNCS possesses oxidase, superoxide dismutase, peroxidase like activities implements self‐cascading enzymatic catalysis produce anion (O 2 •−...
Biofilm formation is a major threat to industry, the environment and human health. While killing of embedded microbes in biofilms may inevitably lead evolution antimicrobial resistance (AMR), catalytic quenching bacterial communications by lactonase promising antifouling approach. Given shortcomings protein enzymes, it attractive engineer synthetic materials mimic activity lactonase. Herein, an efficient lactonase-like Zn-Nx -C nanomaterial was synthesized tuning coordination around zinc...
Abstract Nanozyme‐mediated chemodynamic therapy has emerged as a promising strategy due to its tumor specificity and controlled catalytic activity. However, the poor efficacy caused by low hydrogen peroxide (H 2 O ) levels in microenvironment (TME) poses challenges. Herein, an H self‐supplying nanozyme is constructed through loading peroxide‐like active platinum nanoparticles (Pt NPs) on zinc (ZnO (denoted ZnO @Pt). releases response acidic TME. Pt NPs catalyze hydroxyl radical generation...
Gold complexes can serve as efficient photothermal converters for cancer therapy, but their non-biodegradability hinders clinical bioapplications. Although enormous effort has been devoted, the conventionally adopted synthetic methods of biodegradation are characterized by high cost and complicated procedures, which delay process further translation gold complexes. Here, we report a multifunctional poly(amino acid)–gold–magnetic complex with self-degradation properties synergistic...
Abstract Engineered DNA frameworks have been extensively exploited as affinity scaffolds for drug delivery. However, few studies focus on the rational design to comprehensively improve their stability, internalization kinetics, and loading efficiency. Herein, framework‐based hybrid nanomaterials are rationally engineered by using a molecular docking tool, where framework acts template support conjugated polymers. The materials exhibit high stability in biofluids owning multiple interactions...
Abstract Bacterial‐mediated synergistic cancer therapy (BMSCT) is used as a promising tumor approach. However, there are some disadvantages of bacterial alone to be resolved, such low suppression rate in the treatment. In this study, novel light‐controlled engineered material which synergistically regulates amino acid metabolism fight tumors developed. It transcribes l ‐methionine‐γ‐lyase (MdeA) into Escherichia coli ( E. ) and loads approved photothermal agent indocyanine green (ICG),...
Despite the remarkable number of investigations on potential risks engineered nanomaterials (ENMs) to terrestrial plants, there was limited knowledge regarding effects mesoporous carbon nanoparticles (MCNs) with different sizes crops. The objective our study evaluate toxicity MCNs rice (Oryza sativa L.) seedlings. Two novel particle (MCN1: 150 and MCN2: 80 nm) were synthesized using high-temperature pyrolysis method characterized by transmission electron microscopy (TEM), X-ray photoelectron...