A5007081028- Oral Health Pathology and Treatment
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Salivary Gland Disorders and Functions
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Autoimmune Bullous Skin Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Ocular Diseases and Behçet’s Syndrome
- Intraocular Surgery and Lenses
- Nail Diseases and Treatments
- Cardiac Health and Mental Health
- Angiogenesis and VEGF in Cancer
- Mental Health Research Topics
- Cancer Immunotherapy and Biomarkers
- Family and Patient Care in Intensive Care Units
- Patient-Provider Communication in Healthcare
- Oral and Maxillofacial Pathology
- NF-κB Signaling Pathways
- Music Therapy and Health
- Cancer Diagnosis and Treatment
- Heart Failure Treatment and Management
- Genital Health and Disease
- Glaucoma and retinal disorders
Tianjin Medical University General Hospital
2018-2025
Meizhou City People's Hospital
2013-2024
Sun Yat-sen University Cancer Center
2017-2023
Sun Yat-sen University
1997-2023
The First Affiliated Hospital, Sun Yat-sen University
2023
Medical Research Council
2023
University of Oxford
2022-2023
State Key Laboratory of Oncology in South China
2019-2021
Key Laboratory of Guangdong Province
2019-2021
Qingdao University
2010-2021
The role of locoregional radiotherapy in patients with de novo metastatic nasopharyngeal carcinoma (mNPC) is unclear.To investigate the efficacy and safety mNPC.Patients biopsy-proven mNPC, who demonstrated complete or partial response (RECIST v1.1) following 3 cycles cisplatin fluorouracil chemotherapy, were enrolled. Eligible randomly assigned (1:1) to receive either chemotherapy plus alone. Overall, 126 173 screened eligible study, randomized (n = 63) alone 63). Median (IQR) follow-up...
Summary This study aimed at evaluating the short‐term efficacy and safety of probiotics as an aid in treatment Candida ‐associated stomatitis a randomised controlled trial. A total 65 patients were randomly assigned to receive oral local antifungal agents alone (gargle 2% sodium bicarbonate solution for 30 s, wait 10 min then apply nystatin paste) or these plus (the mixture Bifidobacterium longum , Lactobacillus bulgaricus Streptococcus thermophilus ) three times per day 4 weeks. Parameters...
Amlexanox has been developed as a 5 percent topical oral paste for the treatment of patients with recurrent aphthous stomatitis (RAS) in most European countries. However, it is not yet available China and generally accepted clinical treatment. The aim this study was to explore effectiveness amlexanox adhesive pellicles minor ulcers, compare results those tablets order analyse difference between two dosage forms amlexanox.We performed randomized, blinded, placebo-controlled, parallel,...
We analyzed the number of circulating tumor cells (CTCs) and Epstein–Barr virus DNA (EBV DNA) for diagnosis, monitoring prognosis patients with metastatic nasopharyngeal carcinoma (mNPC). The levels CTCs EBV were measured at baseline after first‐line chemotherapy in 148 mNPC prospectively enrolled between December 2014 August 2016. also collected 122 non‐mNPC cases within same time frame examining baseline. In 270 NPC patients, we observed improved specificity (86.0% vs . 41.0%) inferior...
Cytokines have an important role in the pathogenesis and disease progression of oral lichen planus (OLP). The aim this study was to investigate impact gene polymorphisms T helper cell subtype Th1 Th2 cytokines, interferon-γ (IFN-γ) interleukin-4 (IL-4), on OLP ethnic Chinese cohort. We investigated IFN-γ (IFNG) IL-4 (IL-4) 151 patients with 143 healthy controls using polymerase chain reaction sequence-specific primers (PCR-SSP) method. Each genotype also validated by direct DNA sequencing...
Communication is closely related to safe practice and patient outcomes. Given that most clinicians fall into routines when communicating with patients, it important address communication issues early. This study explores Taiwanese nursing students' experiences of patients cancer their families. Senior students who had cared for were recruited participate in focus group interviews. These semi-structured interviews recorded transcribed content analysis. Among the 45 participants, about 36%...
The National Comprehensive Cancer Network guidelines recommend intensity-modulated radiotherapy (IMRT) as the primary curative treatment for newly diagnosed nasopharyngeal carcinoma (NPC), but radiation-related complications and relatively high medical costs remain a consequential burden patients. Endoscopic nasopharyngectomy (ENPG) was successfully applied in recurrent NPC with radiation free low costs. In this study, we examined whether ENPG could be an effective localized stage I NPC. Ten...
Despite their high accuracy to recognize oral potentially malignant disorders (OPMDs) with cancer risk, non-invasive assays are poor in discerning whether the risk is or low. However, it critical identify levels, since high-risk patients need active intervention, while low-risk ones simply be follow-up. This study aimed at developing a personalized computational model predict level of OPMDs and explore its potential web application screening.Each enrolled patient was subjected following...
Background Toripalimab is a humanized immunoglobulin G 4 monoclonal antibody against programmed death 1. We aimed to investigate the efficacy and safety of toripalimab in combination with intensity-modulated radiotherapy (IMRT) for recurrent nasopharyngeal carcinoma (rNPC). Methods conducted single-arm, phase II trial patients rNPC who had biopsy-proven disease were unsuitable local surgery. Eligible received IMRT administered via intravenous infusion 240 mg once every 3 weeks maximum seven...
Locoregional radiotherapy added to chemotherapy has significantly improved survival in de novo metastatic nasopharyngeal carcinoma (mNPC). However, only 54% of mNPC patients who received sequential chemoradiotherapy have complete or partial response 3 months after radiotherapy. This Simon's optimal two-stage design phase II study (NCT04398056) investigates whether PD-1 inhibitor could improve tumor control combination with chemoradiation. The primary endpoint is objective rate (ORR) at...
Cytokines have an important role in the pathogenesis and disease progression on oral lichen planus (OLP). The aim of this study is to investigate impact gene polymorphisms T-helper cell subtype Th1/Th2 cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10) OLP a Chinese cohort with Han ethnicity. Three single-nucleotide (SNPs) IL-10 at positions -1082G/A, -819C/T, -592C/A one SNP TNF-alpha (TNFG) position -308G/A were analyzed 151 patients 143 healthy controls using...
Li C, Y, Wang X, Z, Cai J, L, Zhao Song H, Meng Ning Xu Lin M, L & Geng J (2012) Histopathology 60, 953–963 Elevated expression of astrocyte elevated gene‐1 (AEG‐1) is correlated with cisplatin‐based chemoresistance and shortened outcome in patients stages III–IV serous ovarian carcinoma Aims: To correlate the clinicopathological features carcinoma, to clinically assess involvement AEG‐1 acquired cisplatin resistance. Methods results: The frequency intensity immunohistochemical increased...
Abstract Background Postradiation nasopharyngeal necrosis (PRNN) is a severe complication after radiotherapy in patients with carcinoma (NPC), which can severely affect the quality of life and threaten patient's life. Only 13.4%–28.6% be cured by traditional repeated endoscopic debridement. Here, we introduced an innovative curative‐intent surgery for PRNN evaluated its clinical efficacy. Methods Clinical data 72 who underwent radical necrectomy, followed reconstruction using posterior...
Background: Reportedly, nasopharyngeal carcinoma (NPC) patients with MHC I Class aberration are prone to poor survival outcomes, which indicates that the deficiency of tumor neoantigens might represent a mechanism immune surveillance escape in NPC. Methods: To clearly delineate landscape NPC, we performed DNA and RNA sequencing on paired primary tumor, regional lymph node metastasis distant samples from 26 patients. Neoantigens were predicted using pVACseq pipeline. Subtype prediction model...
Abstract Background Self-efficacy and mental health present mutually influencing relationships in caregivers of patients with heart failure (HF). There is currently a lack understanding the synergistic developmental mechanisms self-efficacy, anxiety, depression caregivers. The purpose study was to examine individual dual trajectories caregiver during first three months after discharge HF. Methods A prospective cohort conducted from June 2022 May 2024, four tertiary hospitals Tianjin, China....