A5101726454- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Viral-associated cancers and disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Polyomavirus and related diseases
- Oral health in cancer treatment
- Ear and Head Tumors
- Advanced Photocatalysis Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Tracheal and airway disorders
- Chemokine receptors and signaling
- Brain Metastases and Treatment
- Esophageal Cancer Research and Treatment
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
Sun Yat-sen University
2016-2025
Sun Yat-sen University Cancer Center
2016-2025
Xuzhou Central Hospital
2025
Jilin City Central Hospital
2025
Shandong University
2025
Hainan Medical University
2021-2024
Nanjing University
2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2024
State Key Laboratory of Hydraulics and Mountain River Engineering
2022-2024
Zhejiang University of Science and Technology
2024
This study aimed to establish an effective prognostic nomogram with or without plasma Epstein-Barr virus DNA (EBV DNA) for nondisseminated nasopharyngeal carcinoma (NPC). The was based on a retrospective of 4630 patients who underwent radiotherapy chemotherapy at Sun Yat-sen University Cancer Center from 2007 2009. predictive accuracy and discriminative ability the were determined by concordance index (C-index) calibration curve compared EBV current staging system. results validated using...
Objective This research is to analyze the connection between NHHR and CKD occurrence using NHANES from 2001 2018. It will evaluate feasibility of as a tool for predicting CKM syndrome offer valuable insights personalized treatment approaches within U.S. population. Methods Data 16,575 individuals aged 20 69 years were analyzed, having excluded those who pregnant with incomplete data. was characterized by simultaneous presence Cardiometabolic Syndrome (CMS). For statistical analysis, weighted...
To evaluate which patients with nasopharyngeal carcinoma (NPC) obtained the greatest benefits from detection of distant metastasis [(18)F]fluorodeoxyglucose positron emission tomography and computed (PET/CT) combined plasma Epstein-Barr virus (EBV) DNA levels.Consecutive NPC were prospectively enrolled. PET/CT, conventional work-up (CWU), quantification EBV performed before treatment. The accuracy these strategies for metastases was assessed. costs diagnostic compared.Eighty-six (14.8%) 583...
Background The impact of variation Epstein-Barr virus (EBV) antibody titers before the development nasopharyngeal carcinoma (NPC) is still unclear. We analyzed fluctuations antibodies against EBV histopathological diagnosis to assess risk NPC and aimed provide a reliable basis for screening in high populations. Methods This study was based on population-based program Sihui County Guangdong Province China. A total 18,986 subjects were recruited 1987 1992, respectively. Baseline repeated...
A two-stage study was conducted in southern China to determine and validate an optimal combination of Epstein-Barr virus (EBV)-related seromarkers for nasopharyngeal carcinoma (NPC) screening. In the first stage, six [VCA-IgA, EA-IgA, nuclear antigen 1 (EBNA1-IgA), EBNA1-IgG, Zta-IgA Rta-IgG] were detected by enzyme-linked immunosorbent assay (ELISA) two traditional NPC screening (VCA-IgA EA-IgA) immunofluorescence (IFA) serum samples from 191 patients 337 controls. An diagnosis selected...
Abstract Objectives: Nasopharyngectomy is the primary treatment for locally recurrent nasopharyngeal carcinoma (rNPC). However, oncological nasopharyngectomy difficult to achieve, even using extranasal surgical approaches, with potential risks of severe functional disabilities and serious complications. This report introduces an innovative, minimally invasive, oncological, endoscopic nasopharyngectomy. Methods: Between October 2004 January 2008, 37 rNPC patients received nasopharyngectomy,...
Abstract Background Images from magnetic resonance imaging (MRI) are crucial unstructured data for prognostic evaluation in nasopharyngeal carcinoma (NPC). We developed and validated a system based on the MRI features clinical of locoregionally advanced NPC (LA-NPC) patients to distinguish low-risk with LA-NPC whom concurrent chemoradiotherapy (CCRT) is sufficient. Methods This multicenter, retrospective study included 3444 January 1, 2010, 31, 2017. A 3-dimensional convolutional neural...
Induction chemotherapy added to concurrent chemoradiotherapy significantly improves survival for patients with locoregionally advanced nasopharyngeal carcinoma, but the optimal induction regimen remains unclear.To determine whether paclitaxel, cisplatin, and capecitabine (TPC) vs cisplatin fluorouracil (PF) prior stage IVA IVB carcinoma.This randomized, open-label, phase 3 clinical trial recruited 238 at 4 hospitals in China from October 20, 2016, August 29, 2019. Patients were 18 65 years...
Currently, clinically available coronary CT angiography (CCTA) derived fractional flow reserve (CT-FFR) is time-consuming and complex. We propose a novel artificial intelligence-based fully-automated, on-site CT-FFR technology, which combines the automated plaque segmentation luminal extraction model with reduced order 3 dimentional (3D) computational fluid dynamics. A total of 463 consecutive patients 600 vessels from updated China study in Cohort 1 undergoing both CCTA invasive (FFR)...
BACKGROUND The utility of circulating Epstein‐Barr Virus (EBV) DNA as a tumor marker for nasopharyngeal carcinoma (NPC) detection suggests that it might improve the diagnostic performance anti‐EBV antibody markers in NPC screening. In this study, authors evaluated whether EBV load is capable distinguishing patients from high‐risk individuals who have positive antibodies. METHODS population‐based screening trial Sihui City and Zhongshan City, Guangdong Province, China, previously identified...
Adoptive cell therapy (ACT) for cancers using autologous tumor-infiltrating lymphocytes (TILs) can induce immune responses and antitumor activity in metastatic melanoma patients. Here, we aimed to assess the safety of ACT expanded TILs following concurrent chemoradiotherapy (CCRT) patients with locoregionally advanced nasopharyngeal carcinoma (NPC). Twenty-three newly diagnosed, NPC were enrolled, whom 20 received a single-dose TIL infusion CCRT. All treated assessed toxicity, survival...
Purpose This study was conducted to evaluate the prognostic value of treatment-related lymphopenia in patients with nasopharyngeal carcinoma (NPC). Materials and Methods A total 413 consecutive stage II-IVb NPC treated concurrent chemoradiotherapy (CCRT) were enrolled. The overall survival (OS), progression-free (PFS), distant metastasis-free (DMFS) calculated Kaplan-Meier method, differences compared using log-rank test. Results minimum (mini)–absolute lymphocyte counts (ALC) < 390 cells/μL...
Due to the occult anatomic location of nasopharynx and frequent presence adenoid hyperplasia, positive rate for malignancy identification during biopsy is low, thus leading delayed or missed diagnosis nasopharyngeal malignancies upon initial attempt. Here, we aimed develop an artificial intelligence tool detect under endoscopic examination based on deep learning.An images-based detection model (eNPM-DM) consisting a fully convolutional network inception architecture was developed fine-tuned...
The impacts of weight loss on prognosis in nasopharyngeal carcinoma (NPC) remain unclear. present study was therefore undertaken to investigate the association between critical and long-term survival NPC patients. eligible 2399 patients were reviewed. Weight change categorized into (CWL) non-critical (Non-CWL). associations CWL with analyzed by Cox regression entire patient two subsets. Propensity score matching performed reduce effects confounding factors. defined as body ≥4.6 %. Compared...
Capecitabine maintenance therapy improves survival outcomes in various cancer types, but data are limited on the efficacy and safety of capecitabine metastatic nasopharyngeal carcinoma (NPC).To investigate NPC.This randomized phase 3 clinical trial was conducted at Sun Yat-sen University Cancer Center from May 16, 2015, to January 9, 2020, among 104 patients with newly diagnosed NPC who had achieved disease control after 4 6 cycles induction chemotherapy paclitaxel, cisplatin, capecitabine....
Populations of widespread species are usually geographically distributed through contrasting stresses, but underlying genetic mechanisms controlling this adaptation remain largely unknown. Here, we show that in Arabidopsis thaliana, allelic changes the cis-regulatory elements, WT box and W box, promoter a key transcription factor associated with oxygen sensing, RELATED TO AP 2.12 (RAP2.12), responsible for differentially regulating tolerance to drought flooding. These two cis-elements...
Abstract Background Radiation‐induced nasopharyngeal necrosis is a consequential late effect in the patients with carcinoma (NPC). Patients NPC who have been treated high‐dose radiotherapy are at risk of developing postradiation (PRNN). However, analysis PRNN significant cohort has not reported English‐language literature. In this study, we aimed to evaluate 28 NPC. Methods From June 2006 December 2007, were diagnosed pathologic evidence. Surgical procedure endoscopy‐guided debridement and...