A5077844760- Hepatocellular Carcinoma Treatment and Prognosis
- Head and Neck Cancer Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- MRI in cancer diagnosis
- Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Medical Imaging and Pathology Studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Renal cell carcinoma treatment
- Cancer Mechanisms and Therapy
- Sarcoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Circular RNAs in diseases
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
Sun Yat-sen University
2016-2025
State Key Laboratory of Oncology in South China
2014-2025
Sun Yat-sen University Cancer Center
2016-2025
Hebei Medical University
2025
China Medical University
2018-2021
First Hospital of China Medical University
2018-2021
Ministry of Education of the People's Republic of China
2020-2021
National Natural Science Foundation of China
2019
Creative Commons
2019
Guangdong Provincial People's Hospital
2019
Abstract Hepatic arterial infusion chemotherapy (HAIC) using a combination of oxaliplatin, fluorouracil, and leucovorin (FOLFOX) has shown promise for hepatocellular carcinoma (HCC) patients classified under Barcelona Clinic Liver Cancer (BCLC) stage C. In China, the combined therapy camrelizumab apatinib is now an approved first-line approach inoperable HCC. This study (NCT04191889) evaluated benefit combining with HAIC-FOLFOX HCC in BCLC Eligible were given maximum six cycles HAIC-FOLFOX,...
The recurrence of hepatocellular carcinoma (HCC) after minimally invasive therapy is frequent. Adoptive immunotherapy thought to be an effective method lower and metastasis rates malignant tumors. Therefore, 85 HCC patients transcatheter arterial chemoembolization radiofrequency ablation were randomized group no adjuvant group. Autologous cytokine-induced killer (CIK) cells transfused via hepatic artery the patients. alteration levels lymphocyte subsets in peripheral blood was examined by...
Blocking the programmed death protein 1 (PD-1)/programmed death-ligand (PD-L1) pathway in hepatocellular carcinoma (HCC) is a very promising approach immunotherapy. However, correlation and prognostic values of serum soluble PD-1 PD-L1 (sPD-1/sPD-L1) have not been explored conjointly HCC patients. This study retrospectively included 120 patients receiving radical resection. The levels sPD-1/sPD-L1 inflammatory cytokines were measured by antibody array assay. Immunohistochemistry was applied...
Targeted therapy based on adjustment of microRNA (miRNA)s activity takes great promise due to the ability these small RNAs modulate cellular behavior. However, efficacy miR-101 replacement hepatocellular carcinoma (HCC) remains unclear. In current study, we first observed that plasma levels were significantly lower in distant metastatic HCC patients than HCCs without metastasis, and down-regulation predicted a worse disease-free survival (DFS, P<0.05). an animal model HCC, demonstrated...
<p>A reliable system for dynamic prognostication and management of hepatocellular carcinoma (HCC) is urgently needed but currently unavailable. In our previous work, we developed a machine learning algorithm termed "Survival Path" (raw-SP) to enhance with longitudinal survival data. However, the model was limited intermediate stage HCC patients, it faced risk overfitting due path proliferation. this study, novel framework incorporating nodal fusion techniques mitigate overfitting,...
This study evaluated the clinical efficacy of autologous cytokine-induced killer (CIK) cell transfusion in combination with transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA), compared to sequential therapy TACE RFA, for treatment hepatocellular carcinoma (HCC). We retrospectively studied 2 groups HCC patients: 85 patients TACE+RFA+CIK group were treated adoptive CIK minimally invasive therapy, 89 TACE+RFA alone. The overall response rate was 76.5% 79.8% group....
The impacts of weight loss on prognosis in nasopharyngeal carcinoma (NPC) remain unclear. present study was therefore undertaken to investigate the association between critical and long-term survival NPC patients. eligible 2399 patients were reviewed. Weight change categorized into (CWL) non-critical (Non-CWL). associations CWL with analyzed by Cox regression entire patient two subsets. Propensity score matching performed reduce effects confounding factors. defined as body ≥4.6 %. Compared...
Background: An accumulating body of evidence suggests that long non-coding RNAs (lncRNAs) can serve as potential cancer prognostic factors. However, the utility lncRNA combinations in estimating overall survival (OS) for hepatocellular carcinoma (HCC) remains to be elucidated. This study aimed construct a powerful signature related OS HCC enhance accuracy. Methods: The expression patterns lncRNAs and clinical data 371 patients were obtained based on Cancer Genome Atlas (TCGA). Differentially...
ObjectiveMalignant axillary lymph nodes are an important predictor for breast cancer recurrence, but invasive dissection or biopsy is required the diagnosis. We determined whether and how malignant could be diagnosed preoperatively with magnetic resonance (MR) imaging.Materials methodsWe obtained MR images of all women evaluated at Sun Yat-Sen University Cancer Center in 2010 correlated image characteristics each node pathologic diagnosis same node.ResultsWe analyzed 251 (117 benign; 134...
The current metastatic category (M) of nasopharyngeal carcinoma (NPC) is a "catch-all" classification, covering heterogeneous group tumors ranging from potentially curable to incurable. aim this study was design an M categorization system that could be applied in planning the treatment NPC with synchronous metastasis. A total 505 patients diagnosed metastasis at Sun Yat-sen University Cancer Center between 2000 and 2009 were involved. associations clinical variables, features, proposed...
The current M1 stage in nasopharyngeal carcinoma (NPC) does not differentiate patients based on metastatic site and number of metastases. This study aims to subdivide the NPC with bone-only metastases identify who may benefit from combined chemoradiotherapy (CRT).Between 1998 2007, 312 diagnosed metastasis at Sun Yat-sen University Cancer Center were enrolled. Various possible subdivisions considered, including by time order (synchronous vs. metachronous), involvement specific bone site,...
Abstract This study aimed to investigate the role of SOD2 in progression and metastasis salivary adenoid cystic carcinoma (SACC). We analyzed expression 50 SACC patients. Then, effects mechanism on cell a pair different metastatic potential lines was investigated. deregulated patients with SACC. Up-regulation associated distant reduced overall survival disease free - survival. Compared SACC-83 cells (lower ability), SACC-LM (higher ability) had higher activity intracellular H 2 O...
Abstract Purpose This study compares the efficacy and safety of lenvatinib programmed cell death protein (PD)‐1 versus alone for advanced hepatocellular carcinoma (Ad‐HCC) refractory to hepatic arterial infusion chemotherapy (HAIC). Methods From April 2016 September 2021, 145 patients with Ad‐HCC HAIC based on modified Response Evaluation Criteria in Solid Tumors criteria were enrolled by two radiologists classified into HAIC‐lenvatinib group (H‐L, n = 87) HAIC‐lenvatinib‐PD‐1 (H‐L‐P, 58). A...
Abstract BACKGROUND: Microwave ablation has recently been developed as a safe and effective treatment for variety of tumors. The authors evaluated the safety efficacy computed tomography (CT)‐guided percutaneous microwave adrenal malignant METHODS: Nine patients between 41 83 years age (average age, 54 years) with carcinoma (a total 10 lesions) received CT‐guided water‐cooled ablation. 9 cases included 1 primary adrenocortical 8 metastatic carcinomas (4 from lung cancer, 2 hepatocellular...
A series of modifications have been introduced to the TNM staging system over time for nasopharyngeal carcinoma (NPC), mainly focused on T (primary tumor) and N (local node) components system. The M1 stage is a 'catch all' classification, covering group patients whose outlook ranges from potentially curable incurable. Since current does not allow clinicians stratify according prognosis or guide therapeutic decision-making comparison results radical non-radical treatments, we aimed subdivide...
Purpose To assess the effectiveness and safety of percutaneous computed tomography (CT)-guided radiofrequency ablation (RFA) for lymph node (LN) oligometastases from hepatocellular carcinoma (HCC). Materials Methods This retrospective study was approved by institutional ethics committee, all patients provided written informed consent. From January 2004 to December 2013, 119 consecutive with HCC LN (115 men [mean age, 51.3 years; age range, 16-83 years] four women 38.2 23-47 years]) were...
Background Transarterial chemoembolization (TACE) is an effective downstaging procedure for hepatocellular carcinoma (HCC). However, knowledge of the effectiveness radiofrequency ablation (RFA) after HCC currently lacking. Purpose To evaluate clinical outcomes RFA by using TACE. Materials and Methods This retrospective study investigated a cohort patients who underwent with curative intent TACE to meet Milan criteria (one lesion up 5 cm or no more than three lesions ≤3 without vascular...