A5102004283- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Medical Imaging and Pathology Studies
- Immunotherapy and Immune Responses
- Ferrocene Chemistry and Applications
- Metal complexes synthesis and properties
- Hepatitis C virus research
- Lung Cancer Diagnosis and Treatment
- Actinomycetales infections and treatment
- DNA Repair Mechanisms
- Tryptophan and brain disorders
- Synthesis and biological activity
- Genetic and Kidney Cyst Diseases
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Liver Disease and Transplantation
- Adrenal and Paraganglionic Tumors
- Cancer, Lipids, and Metabolism
- Advanced Radiotherapy Techniques
- Ferroptosis and cancer prognosis
Third Affiliated Hospital of Sun Yat-sen University
2017-2025
Sun Yat-sen University
2016-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2021
Sun Yat-sen University Cancer Center
2016-2021
State Key Laboratory of Oncology in South China
2017
Interventional hepatic arterial infusion chemotherapy of infusional fluorouracil, leucovorin, and oxaliplatin (HAIC-FO) displayed an encouraging safety profile antitumor activity in a previous phase II trial propensity-score-matching study involving patients with locally advanced hepatocellular carcinoma (HCC).In this open-label, III trial, HCC, previously untreated systemic therapy, were randomly assigned 1:1 ratio to receive HAIC-FO or sorafenib. The primary end point was overall survival...
Combining anti-angiogenic therapy with immune checkpoint blockade anti-programmed cell death-1 (PD-1) antibodies is a promising treatment for hepatocellular carcinoma (HCC). Tyrosine kinase inhibitors are well-known agents and offer potential combination anti-PD-1 antibodies. This study investigated the possible underlying immunomodulatory mechanisms of combined therapy.HCC tissue samples RNA-sequencing (RNA-seq) were obtained from patients differential prognoses following treatment....
It is well known that the aberrant expression of programmed death ligand 1 (PD-L1) on tumor cells impairs antitumor immunity. To date, in hepatocellular carcinoma (HCC), relationship between PD-L1 and host-tumor immunity not defined. Here, levels CD8+ T cell infiltration were analyzed by immunohistochemistry (IHC) formalin fixed paraffin embedded (FFPE) specimens from 167 HCC patients undergoing resection. A significant positive association was found presence (p < 0.0001). Moreover,...
Background & Aims:We compared the efficacy of transcatheter arterial chemoembolization (TACE) in combination with CT-guided radiofrequency ablation (RFA) that surgical resection (SR) patients hepatocellular carcinoma (HCC) within up-to-seven criteria.Methods: From January 2004 to December 2014, 420 multicenter consecutive HCC who conformed criteria and initially received either TACE plus RFA (TACE-RFA) or SR were enrolled.A matched cohort composed 206 was selected after adjustment propensity...
Background: The anti-programmed cell death protein-1 (PD-1) inhibitor is one of the second-line therapies for advanced hepatocellular carcinoma (HCC) after sorafenib failure. goal this study to evaluate feasibility and safety ablation on tumor in patients with HCC who had stable disease or atypical response during single anti-PD-1 therapy Atypical defined as mixed responses different lesions same individual (e.g., active progressive lesions). Patients Methods: This proof-of-concept clinical...
Background The incidence and mortality of hepatocellular carcinoma (HCC) had increased globally over the past decades. Previous studies found that transarterial chemoembolization (TACE) combined with lenvatinib also shown efficacy in unresectable HCC. We aimed to evaluate safety TACE camrelizumab treat multiple nodular large HCC (>5 cm). Materials methods Between November 2018 June 2021, we retrospectively recruited 82 patients (BCLC stage B or C a single diameter >5 Of who not...
Intrahepatic cholangiocarcinoma (iCCA) is the second most common liver malignancy with poor prognosis and limited treatment options. To identify effective drug for transarterial chemoembolization (TACE) in evaluate efficacy safety of combining it gemcitabine cisplatin (GemCis) unresectable iCCA. Cholangiocarcinoma cell lines (RBE, HuCC-T1) were treated 10 chemotherapeutic drugs, cytotoxicity was assessed by counting kit-8 assays. Tumor-bearing nude mice idarubicin or GemCis, tumor growth...
Indoleamine 2,3‐dioxygenase 1 ( IDO 1) is a tryptophan‐metabolizing enzyme that widely distributed in normal or malignant tissues and contributes to immunologic tolerance immune escape. However, hepatocellular carcinoma HCC ), the characteristics mechanism of expression have not been well defined. In this study, tumor cells (T‐ was frequently detected (109/112) by immunohistochemistry formalin‐fixed paraffin‐embedded specimens from patients, patterns were mostly focal (102/109). Expression...
Background: The aim of this study was to evaluate the therapeutic outcome percutaneous computed tomography (CT)-guided radiofrequency ablation (RFA) for extrahepatic oligometastases hepatocellular carcinoma (HCC).Methods: Institutional review board approval obtained retrospective study, and all patients provided written informed consent. Between April 2004 December 2015, 116 (diameter, 5–50 mm; 20.3 ± 10.4) in 79 consecutive HCC (73 men 6 women; average age, 50.3 years ±13.0) were treated...
Background: This study aimed to compare the treatment outcomes and safety between stent placement with or without Iodine-125 (125I) seeds strand for patients unresectable malignant obstructive jaundice (MOJ).Methods: A total of 84 MOJ treated in our hospital were retrospectively included divided into group (n = 54) undergoing biliary + 30) receiving 125I strand. The therapeutic outcome, postoperative complications, duration patient survival patency compared groups. Kaplan-Meier analysis was...
Purpose: To evaluate the safety, efficacy, and survival outcomes of computed tomography (CT)-guided thermal ablation for adrenal metastases from hepatocellular carcinoma (HCC). Methods: This long-term retrospective study included 27 male patients (median age, 50 years; range, 34-77 years) with 29 metastatic tumors associated HCC who underwent between January 2004 December 2015. The technical success rate, effectiveness complications, were recorded. Complications assessed according to Common...
Background & aims Optimizing transarterial chemoembolization (TACE) can enhance treatment efficacy for hepatocellular carcinoma (HCC). This study compares modified TACE (M-TACE), which combines a lipiodol-based emulsion and drug-eluting beads, with bead (DEB-TACE) as initial therapies solitary HCC.
A chiral ruthenium(ii) complex, Λ-[Ru(bpy)2(o-tFMPIP)] (ClO4)2 (o-tFMPIP = 2'-trifluoromethylphenyl) imidazo [4,5-f][1,10]phenanthroline, was prepared and evaluated for its enhancement of the radiosensitivity 125I seeds. The synthetic Ru(ii) LR042, effectively enhanced growth inhibition against HepG2 human hepatocellular liver carcinoma cells induced by seeds consequently promoted apoptosis tumor with increasing level cleave-caspase-3. Furthermore, results immunofluorescence indicated that...
Abstract Background To date, no standard follow-up guidelines exist regarding patients receiving ablation for initial recurrent hepatocellular carcinoma (HCC). We aimed to explore whether intensive could benefit these patients. Methods reviewed the clinical data of who received complete HCC recurrence after curative treatments in our institution from January 2005 June 2017. Risk factors second were identified by univariate and multivariate analyses. Patients classified into low- high-risk...
Two new ruthenium(II) complexes, [Ru(bpy)2(DClPIP)](ClO4)2 (1) and [Ru(phen)2(DClPIP)](ClO4)2 (2) (bpy = 2,2′-bipyridine, phen 1,10-phenanthroline, DClPIP 2-(2,4-dichlorophenyl)-1H-imidazo[4,5-f][1, 10]phenanthroline), have been prepared in high yield by using microwave-assisted synthesis technology. The anticancer activity of the two complexes against A549, C6, CNE-1 MDA-MB-231 cell lines has evaluated MTT assay results showed that 2 exhibited higher antitumor than 1 toward all selected...
To further evaluate the efficacy and safety of computed tomography (CT)-guided iodine 125 (125I) brachytherapy to treat locally advanced non-small cell lung cancer (NSCLC) after progression concurrent radiochemotherapy (CCRT).This study obtained written consent from all patients was approved by our institution. From January 2006 June 2018, 210 NSCLC (progression first-line CCRT) were retrospectively recruited then divided into two groups. A total 116 given CT-guided 125I second-line...