A5053387702- Immune Cell Function and Interaction
- Galectins and Cancer Biology
- Helicobacter pylori-related gastroenterology studies
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Glycosylation and Glycoproteins Research
- Infant Nutrition and Health
- Rheumatoid Arthritis Research and Therapies
- CRISPR and Genetic Engineering
- Plant biochemistry and biosynthesis
- Pancreatic function and diabetes
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Chemokine receptors and signaling
- Gut microbiota and health
- Microbial Metabolic Engineering and Bioproduction
- CAR-T cell therapy research
University of Kansas
2024
First Affiliated Hospital of Zhengzhou University
2023
University of Minnesota Medical Center
2018-2022
Shandong University
2022
Guangzhou Medical University
2021
Sun Yat-sen University
2016-2021
Sun Yat-sen University Cancer Center
2016-2021
University of Minnesota
2017-2021
Second Affiliated Hospital of Dalian Medical University
2018
Dalian Medical University
2018
Backgrounds G-protein-coupled receptor 84 (GPR84) marks a subset of myeloid-derived suppressor cells (MDSCs) with stronger immunosuppression in the tumor microenvironment. Yet, how GPR84 endowed inhibition MDSCs to CD8 + T function is not well established. In this study, we aimed identify underlying mechanism behind by MDSCs. Methods The role and that or exosomes (Exo) regulates were investigated using immunofluorescence, fluorescence activating cell sorter (FACS), quantitative real-time...
It is well known that the aberrant expression of programmed death ligand 1 (PD-L1) on tumor cells impairs antitumor immunity. To date, in hepatocellular carcinoma (HCC), relationship between PD-L1 and host-tumor immunity not defined. Here, levels CD8+ T cell infiltration were analyzed by immunohistochemistry (IHC) formalin fixed paraffin embedded (FFPE) specimens from 167 HCC patients undergoing resection. A significant positive association was found presence (p < 0.0001). Moreover,...
Research Article25 June 2018Open Access Source DataTransparent process Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation Ming Zhao School of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China Department Integrative Biology and Physiology, University Minnesota School, Minneapolis, MN, USA Search for more papers by this author Xiwen Xiong Kaiqun Ren College Hunan Normal Changsha, Hunan, Bing Xu State Key Laboratory Cancer & Institute...
White adipose tissue (WAT) homeostasis substantiated by type 2 immunity is indispensable to counteract obesity and metabolic disorders. IL-33/suppression of tumorigenicity (ST) signaling promotes response in WAT, while potential regulators remain be discovered. We identified human IL-37 isoform D (IL-37D) as an effective trigger for ST2-mediated immune WAT. IL-37D transgene amplified ST2+ cells, promoted M2 macrophage polarization cytokine secretion WAT that mediate beiging inflammation...
Lycopene represents one of the central compounds in carotenoid pathway and it exhibits a potent antioxidant ability with wide potential applications medicine, food, cosmetics. The microbial production lycopene has received increasing concern recent years. Corynebacterium glutamicum (C. glutamicum) is considered to be safe beneficial industrial platform, naturally endowed produce lycopene. However, scarcity efficient genetic tools challenge identifying crucial metabolic genes impede further...
More than 1 billion people worldwide are infected with helminths, which may nutritionally and physically impair people, particularly children. Tuft cells lying in the intestinal epithelium have been recently proposed to sense parasitic worms lumen initiate type 2 immunity, turn remodels expulses parasites. However, little is known regarding molecular mechanisms underlying tuft cell hyperplasia. O‐linked N‐Acetylglucosamine (O‐GlcNAc), a posttranslational modification that decorates single...
The epithelium is an integral component of mucosal barrier and host immunity. Following helminth parasite infection, the intestinal epithelial cells secrete "alarmin" cytokines, such as interleukin (IL)-25 IL-33, to initiate type 2 immune responses for expulsion tolerance. However, it unknown how infection resulting cytokine milieu drive remodeling orchestrate alarmin secretion. Here we report that, O-linked N-Acetylglucosamine (O-GlcNAc) protein modification induced upon infections. By...
The gut microbiota plays a fundamental role for host metabolism and immune response. Alterations in microbial composition function have been associated with many diseases, including obesity, diabetes, inflammatory bowel disease, liver diseases. Microbial yields number of bioactive molecules such as short‐chain fatty acids (SCFAs) that may modulate physiology; however, the molecular mechanisms by which cells sense respond to microbiota‐derived are largely unknown. O‐linked...
<h3>Background</h3> Active refractory rheumatoid arthritis (RA) is common in real-world. Patients with active RA usually have poor prognosis. And they respond poorly to a variety of therapies. The arrival remission or low disease activity (LDA) as soon possible an important way improve their We investigated the effectiveness immunoadsorption therapy, novel blood purification treatment, rapid and sustained disease-modifying therapy for RA. <h3>Objectives</h3> To evaluated efficacy additional...
Abstract The tuft cell-type 2 innate lymphoid cell circuit has emerged as a critical component of mucosal type immunity against helminth, which infects more than 1 billion people worldwide. However, little is known regarding the molecular mechanisms underlying cytokine-induced hyperplasia. O-linked N-Acetylglucosamine (O-GlcNAc), posttranslational modification on intracellular proteins at serine and threonine residues, plays central role in many biological processes such gene transcription,...
Abstract The application of Chimeric antigen receptor (CAR) T cells in solid tumors is hindered by lack tumor specific targets and inefficient cell infiltration tumor. It has been postulated that AXL may be an ideal immunotherapy target for non-small-cell lung cancer (NSCLC). Here, we screened 208 non-tumor samples from 22 types human organs or tissues 90 NSCLC patients immunohistochemistry Western Blotting identified was rarely expressed normal but highly 69% samples, suggesting CAR therapy...