A5029525481- Adipose Tissue and Metabolism
- Glycosylation and Glycoproteins Research
- Mitochondrial Function and Pathology
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Galectins and Cancer Biology
- Lipid metabolism and biosynthesis
- IL-33, ST2, and ILC Pathways
- Hematopoietic Stem Cell Transplantation
- Carbohydrate Chemistry and Synthesis
- Acute Myeloid Leukemia Research
- Chemokine receptors and signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic and phenotypic traits in livestock
- Muscle Physiology and Disorders
- Cancer-related molecular mechanisms research
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Cancer, Hypoxia, and Metabolism
- Vector-Borne Animal Diseases
- Cardiovascular Disease and Adiposity
- Retinoids in leukemia and cellular processes
- Pancreatic function and diabetes
- Agriculture Sustainability and Environmental Impact
- RNA Research and Splicing
Southwest Minzu University
2024
State Ethnic Affairs Commission
2024
University of Minnesota Medical Center
2019-2023
University of Minnesota System
2021-2023
Nanjing Agricultural University
2023
University of Minnesota
2019-2022
Hematopoiesis is dynamically regulated by metabolic cues in homeostatic and stressed conditions; however, the cellular molecular mechanisms mediating sensing regulation remain largely obscure. Bone marrow adipose tissue remodels various conditions has been recently proposed as a niche for hematopoietic stem cells after irradiation. Here, we investigated role of tissue-derived cytokine cell factor unperturbed hematopoiesis selectively ablating Kitl gene from adipocytes bone stroma using...
Human brown adipose tissue (BAT) undergoes progressive involution. This involution process is not recapitulated in rodents, and the underlying mechanisms are poorly understood. Here we show that interscapular BAT (iBAT) of rabbits whitens rapidly during early adulthood. The transcriptomic remodeling identity switch mature adipocytes accompanied by loss adipogenic competence progenitors. Single-cell RNA sequencing reveals rabbit human iBAT progenitors highly express FSTL1 gene. When involutes...
In mammals, interactions between the bone marrow (BM) stroma and hematopoietic progenitors contribute to bone-BM homeostasis. Perinatal growth ossification provide a microenvironment for transition definitive hematopoiesis; however, mechanisms orchestrating development of skeletal systems remain largely unknown. Here, we establish intracellular O-linked β-N-acetylglucosamine (O-GlcNAc) modification as posttranslational switch that dictates differentiation fate niche function early BM stromal...
The goat breeding industry on the Tibetan Plateau faces strong selection pressure to enhance fertility. Consequently, there is an urgent need develop lines with higher fertility and adaptability. ovary, as a key organ determining reproductive performance, regulated by complex transcriptional network involving numerous protein-coding non-coding genes. However, molecular mechanisms of mRNA-miRNA-lncRNA regulatory in ovaries remain largely unknown. This study focused histology differential...
Abstract Adding adipose cells to cell-cultured meat can provide a distinctive aroma and juicy texture similar real meat. However, significant challenge still exists in obtaining seed that be propagated for long periods, maintain their adipogenic potential, reduce production costs. In this study, we present cell strain derived from immortalized porcine preadipocytes subculture over 40 passages without losing differentiation capacity. This differentiated within 3D bioscaffolds generate fat...
The immunosuppressive regulatory T (Treg) cells exert emerging effects on adipose tissue homeostasis and systemic metabolism. However, the metabolic regulation effector mechanisms of Treg in coping with obesogenic insults are not fully understood. We have previously established an indispensable role O-linked N-Acetylglucosamine (O-GlcNAc) signaling maintaining cell identity promoting suppressor function, via STAT5 O-GlcNAcylation activation. Here, we investigate O-GlcNAc transferase...
Brown adipose tissue (BAT) dissipates energy as heat, contributing to temperature control, expenditure, and systemic homeostasis. In adult humans, BAT mainly exists in supraclavicular areas its prevalence is associated with cardiometabolic health. However, the developmental origin of remains unknown. Here, using genetic cell marking mice, we demonstrate that brown adipocytes do not develop from Pax3 + / Myf5 epaxial dermomyotome gives rise interscapular (iBAT). Instead, Tbx1 lineage...
SUMMARY In mammals, interactions between the bone marrow (BM) stroma and hematopoietic progenitors contribute to bone-BM homeostasis. Perinatal growth ossification provide a microenvironment for transition definitive hematopoiesis; however, mechanisms orchestrating development of skeletal systems remain largely unknown. Here, we establish intracellular O-linked β-N-acetylglucosamine (O-GlcNAc) modification as posttranslational switch that dictates differentiation fate niche function early BM...
SUMMARY In humans, brown adipose tissue (BAT) undergoes progressive involution or atrophy with increasing age, as manifested by decreased prevalence and mass, transformation to white (WAT), reduction in thermogenic activity. This process cannot be fully recapitulated rodent models thus underlying cellular mechanisms are poorly understood. Here, we show that the interscapular BAT (iBAT) rabbits involutes rapidly early life, similarly humans. The transcriptomic remodeling identity switch of...
SUMMARY Brown adipose tissue (BAT) dissipates energy as heat, contributing to temperature control, expenditure, and systemic homeostasis. In adult humans, BAT mainly exists in supraclavicular areas its prevalence is associated with cardiometabolic health. However, the developmental origin of remains unknown. Here, using genetic fate mapping mice, we demonstrate that brown adipocytes do not develop from Pax3 + / Myf5 epaxial dermomyotome gives rises interscapular BAT. Instead, Tbx1 lineage...
The epithelium is an integral component of mucosal barrier and host immunity. Following helminth parasite infection, the intestinal epithelial cells secrete "alarmin" cytokines, such as interleukin (IL)-25 IL-33, to initiate type 2 immune responses for expulsion tolerance. However, it unknown how infection resulting cytokine milieu drive remodeling orchestrate alarmin secretion. Here we report that, O-linked N-Acetylglucosamine (O-GlcNAc) protein modification induced upon infections. By...
Brown adipose tissue (BAT) is a thermogenic organ that promotes metabolic fitness. In humans, there are two spatiotemporally distinct phases of BAT ontogeny: the prenatally developed dorsal-anterior-located interscapular (iBAT); and postnatally emerged supraclavicular (sBAT). It has been established in rodents iBAT depots predominately arise from Pax3 + / Myf5 lineage epaxial dermomyotome also forms trunk muscle. However, developmental origins adult humans have remain unknown. this study,...
In humans, there is a striking decrease in the prevalence and activity of brown adipose tissue (BAT) with age obesity; however, cellular molecular mechanisms BAT remodeling are almost completely unknown. Rodent models have been widely used to study but they possess constitutively active throughout life even at thermoneutrality; therefore, complementary animal that characteristics human needed. Here, we found progressively whitened rabbits similar manner as humans. As mature, preadipocytes...
In the bone marrow stroma, skeletal stem cells (SSCs) and their derived stromal cells, osteoblasts adipocytes (BMAs) provide niche microenvironment to support self-renewal differentiation of hematopoietic (HSCs). However, it’s still largely mysterious how bone-fat balance is disrupted whether adiposity contributes skewed HSCs toward myeloid over lymphoid cells. Here we showed that O-linked β-N-acetylglucosamine (O-GlcNAc) modification on intracellular proteins determined adipogenic vs....
In humans, there is a striking decrease in the prevalence and activity of brown adipose tissue (BAT) with age obesity; however, cellular molecular mechanisms BAT remodeling are almost completely unknown. Rodent models have been widely used to study but they possess constitutively active throughout life even at thermoneutrality; therefore, complementary animal that characteristics human needed. Here, we found progressively whitened rabbits similar manner as humans. As mature, preadipocytes...