A5017218996- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Glycosylation and Glycoproteins Research
- Meat and Animal Product Quality
- Animal Nutrition and Physiology
- Agriculture Sustainability and Environmental Impact
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Chemokine receptors and signaling
- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Gut microbiota and health
- Galectins and Cancer Biology
- Lipid metabolism and biosynthesis
- Digestive system and related health
- Dietary Effects on Health
- Pancreatic function and diabetes
- Cardiac Fibrosis and Remodeling
- FOXO transcription factor regulation
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Congenital heart defects research
Nanjing Agricultural University
2015-2024
South China University of Technology
2024
University of Minnesota Medical Center
2018-2023
Département Santé Animale
2023
University of Minnesota System
2023
University of Minnesota
2016-2021
Nanjing University
2013-2018
Model Animal Research Center
2013-2018
Nanjing Drum Tower Hospital
2018
Hebei Medical University
1990-1992
Disrupted mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) generation are often associated with macrophage pyroptosis. It remains unclear how these forms of dysfunction relate to inflammasome activation gasdermin-D (Gsdmd) cleavage, two central steps the pyroptotic process. Here, we also found MMP collapse ROS induced by Nlrp3 as previous studies reported. The elimination alleviated cleavage Gsdmd, suggesting that Gsdmd occurs downstream release. Consistent this...
Abstract Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce cell death. Here, we show that is highly expressed leukocytes septic shock patients, which increased release D (GSDMD) N-terminus. expression and accumulation N-terminal fragment GSDMD are induced activation non-canonical pyroptosis pathway a human...
Gasdermin A3 (Gsdma3) was originally identified in association with hair-loss phenotype mouse mutants. Our previous study found that AE mutant mice, a Y344H substitution at the C-terminal domain of Gsdma3, display inflammation-dependent alopecia and excoriation [Zhou et al. (2012) Am. J. Pathol. 180, 763–774]. Interestingly, we newly-generated null Gsdma3 mice did not skin dysmorphology, indicating is essential for differentiation epidermal cells maintenance hair cycle normal physiological...
Abstract The evidence of gut microbiota‐mediated modulation brain function has been widely recognized from studies using germ‐free rodents or animals with oral antibiotic‐induced microbiota depletion. Since the large intestine harbors greater numbers and more diverse microbes than in small intestine, intestinal may play a crucial role function. In this study, microbiota‐targeted strategy was used to investigate impact on Twelve piglets (12.08 ± 0.28 kg) fitted T‐cannula at distal ileum were...
Hematopoiesis is dynamically regulated by metabolic cues in homeostatic and stressed conditions; however, the cellular molecular mechanisms mediating sensing regulation remain largely obscure. Bone marrow adipose tissue remodels various conditions has been recently proposed as a niche for hematopoietic stem cells after irradiation. Here, we investigated role of tissue-derived cytokine cell factor unperturbed hematopoiesis selectively ablating Kitl gene from adipocytes bone stroma using...
Human brown adipose tissue (BAT) undergoes progressive involution. This involution process is not recapitulated in rodents, and the underlying mechanisms are poorly understood. Here we show that interscapular BAT (iBAT) of rabbits whitens rapidly during early adulthood. The transcriptomic remodeling identity switch mature adipocytes accompanied by loss adipogenic competence progenitors. Single-cell RNA sequencing reveals rabbit human iBAT progenitors highly express FSTL1 gene. When involutes...
Follistatin-like 1 (Fstl1) protects cardiomyocytes from a broad spectrum of pathologic injuries including myocardial infarction (MI). It is worthy note that although cardiac Fstl1 elevated in post-MI microenvironment, its cardioprotective role still restricted to limited extent considering the frequency and severity adverse remodeling following MI. We therefore propose intrinsic Fstl1-suppressing microRNA (miRNA) may exist heart neutralization further facilitate recovery. Here, miR-9-5p...
Research Article25 June 2018Open Access Source DataTransparent process Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation Ming Zhao School of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China Department Integrative Biology and Physiology, University Minnesota School, Minneapolis, MN, USA Search for more papers by this author Xiwen Xiong Kaiqun Ren College Hunan Normal Changsha, Hunan, Bing Xu State Key Laboratory Cancer & Institute...
Body weight regain often causes failure of obesity therapies while the underlying mechanism remains largely unknown. In this study, we report that immune cells, especially CD4+ T mediate 'memory' previous obese status. a gain-loss-regain model, found C57BL/6J mice with an history showed much faster rate body regain. This memory could last for at least 2 months after previously were kept same as non-obese mice. Surprisingly, such was abrogated by dexamethasone treatment, whereas...
In mammals, interactions between the bone marrow (BM) stroma and hematopoietic progenitors contribute to bone-BM homeostasis. Perinatal growth ossification provide a microenvironment for transition definitive hematopoiesis; however, mechanisms orchestrating development of skeletal systems remain largely unknown. Here, we establish intracellular O-linked β-N-acetylglucosamine (O-GlcNAc) modification as posttranslational switch that dictates differentiation fate niche function early BM stromal...
Previous studies have demonstrated that L. delbrueckii plays beneficial roles in modulating the gut microbiota, enhancing intestinal barrier, and promoting animal growth. Postbiotics a similar or even superior effect protecting health compared to probiotics due their excellent stability, extended shelf life, safety. However, protective effects underlying mechanism of postbiotics from inflammation remain unclear. In this study, we impact on by establishing S. Typhimurium-induced model mice,...
Abstract Background Cell therapy remains the most promising approach against ischemic heart injury. However, poor survival of engrafted cells in sites diminishes its therapeutic efficacy. Follistatin-like 1 (Fstl1) is documented as a novel pro-survival cardiokine for cardiomyocytes, and it protective during In present study, we characterize potential Fstl1 an effective strategy to enhance hypoxia resistance donor optimize stem cell-based therapy. Methods Murine bone marrow-derived...
Changes in metabolic pathway preferences are key events the reprogramming process of somatic cells to induced pluripotent stem (iPSCs). The optimization conditions can enhance reprogramming; however, detailed underlying mechanisms largely unclear. By comparing gene expression profiles cells, intermediate-phase and iPSCs, we found that carnitine palmitoyltransferase (Cpt)1b, a rate-limiting enzyme fatty acid oxidation, was significantly upregulated early stage process. Mouse embryonic...
Feeding high-fiber diets decreases cost, but also caloric and nutritional efficiency by modifying intestinal morphology function. We analyzed the changes in cell composition, nutrient transporters receptors, differentiation induced fibers from different sources. Forty-six finishing pigs (BW 84 ± 7 kg) were fed 1 of 4 diets: corn-soybean (Control; = 12), 23% wheat straw (WS; 11), 55% corn distillers dried grains with solubles (DDGS; 30% soybean hulls (SBH; 12). Pigs 2 meals daily to an amount...
High-fat diet (HFD) feeding is known to cause intestinal barrier disruption, thereby triggering severe inflammatory disease. Indole-3-aldehyde (IAld) has emerged as a potential candidate for mitigating responses and maintaining homeostasis. However, the role of IAld in HFD-related disruption remains unclear. In this study, 48 7 week-old male C57BL/6J mice were assigned four groups: normal chow (NCD) group received NCD; HFD was fed an HFD; + IAld200 supplemented with 200 mg/kg IAld600 600...
Studies using in vitro cultured oocytes have indicated that the protein phosphatase 2A (PP2A), a major serine/threonine phosphatase, participates multiple steps of meiosis. Details oocyte maturation regulation by PP2A remain unclear and an vivo model can provide more convincing information. Here, we inactivated mutating genes encoding for its catalytic subunits (PP2Acs) mouse oocytes. We found eliminating both PP2Acs caused female infertility. Oocytes lacking failed to complete 1st meiotic...
Protein phosphatase 2A (PP2A) is a key negative regulator of phosphatidylinositol 3-kinase/Akt pathway. Previous study showed that, in the liver, catalytic subunit PP2A (PP2Ac) closely associated with insulin resistance syndrome, which characterized by glucose intolerance and dyslipidemia. Here we studied role liver PP2Ac metabolism evaluated whether suitable therapeutic target for treating syndrome. Liver-specific Ppp2cα knockout mice (Ppp2cαloxp/loxp: Alb) exhibited improved homeostasis...
Gastrointestinal (GI) functions affect gut nutrient flow and microbial metabolism. Dietary peptides modulate GI improve small intestinal health, but the mechanism remains elusive. This study aims to investigate whether dietary metabolism, underlying mechanisms. An ileal-cannulated pig model is adopted explore relationship between metabolism after treatment with hydrolyzed casein (peptides) or intact (Control)-based diet. The results demonstrate that enhances carbohydrate higher Streptococcus...
Abstract Adding adipose cells to cell-cultured meat can provide a distinctive aroma and juicy texture similar real meat. However, significant challenge still exists in obtaining seed that be propagated for long periods, maintain their adipogenic potential, reduce production costs. In this study, we present cell strain derived from immortalized porcine preadipocytes subculture over 40 passages without losing differentiation capacity. This differentiated within 3D bioscaffolds generate fat...
Peroxisome proliferator-activated receptor-γ (PPARγ) is a master regulator of adipogenesis and target the thiazolidinedione (TZD) class antidiabetic drugs; therefore, identifying novel regulators PPARγ action in adipocytes essential for future development therapeutics diabetes. MAGE family member D1 (MAGED1), by acting as an adaptor ubiquitin-dependent degradation pathways co-factor transcription, plays important role neural development, cell differentiation circadian rhythm. Here, we showed...
To investigate the effect of interleukin-6 (IL-6) gene knockout on apoptosis myocardial cells in mice with Coxsackievirus B3 (CVB3)-induced dilated cardiomyopathy (DCM) and its potential mechanism, so as to provide certain references for clinical prevention treatment DCM.A total 40 male C57 were randomly divided into Sham group (n=20) DCM using a random number table. Another 20 IL-6 enrolled DCM+IL-6 KO (n=20). The model was established via CVB3 repeated incremental infection. After 9...