A5100352751- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- MRI in cancer diagnosis
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced MRI Techniques and Applications
- Angiogenesis and VEGF in Cancer
- Renal and related cancers
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sarcoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Advanced X-ray and CT Imaging
- Lung Cancer Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Respiratory viral infections research
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- COVID-19 diagnosis using AI
- Functional Brain Connectivity Studies
- Medical Imaging and Pathology Studies
- Radio Frequency Integrated Circuit Design
First Affiliated Hospital Zhejiang University
2010-2025
Zhejiang University
2016-2025
Sir Run Run Shaw Hospital
2024
Washington University in St. Louis
2011-2024
Nanjing Medical University
2020-2024
Sun Yat-sen University
2011-2024
Eighth Affiliated Hospital of Sun Yat-sen University
2024
Xiangtan University
2024
Ruikang Affiliated Hospital of Guangxi Medical University
2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2024
To elucidate the deregulated functional modules that drive clear cell renal carcinoma (ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic, and phosphoproteomic characterization of treatment-naive ccRCC paired normal adjacent tissue samples. Genomic analyses identified a distinct molecular subgroup associated with genomic instability. Integration proteogenomic measurements uniquely protein dysregulation cellular mechanisms impacted by alterations, including...
Clear cell renal carcinomas (ccRCCs) represent ∼75% of RCC cases and account for most RCC-associated deaths. Inter- intratumoral heterogeneity (ITH) results in varying prognosis treatment outcomes. To obtain the comprehensive profile ccRCC, we perform integrative histopathologic, proteogenomic, metabolomic analyses on 305 ccRCC tumor segments 166 paired adjacent normal tissues from 213 cases. Combining histologic molecular profiles reveals ITH 90% ccRCCs, with 50% demonstrating immune...
A two-stage study was conducted in southern China to determine and validate an optimal combination of Epstein-Barr virus (EBV)-related seromarkers for nasopharyngeal carcinoma (NPC) screening. In the first stage, six [VCA-IgA, EA-IgA, nuclear antigen 1 (EBNA1-IgA), EBNA1-IgG, Zta-IgA Rta-IgG] were detected by enzyme-linked immunosorbent assay (ELISA) two traditional NPC screening (VCA-IgA EA-IgA) immunofluorescence (IFA) serum samples from 191 patients 337 controls. An diagnosis selected...
Since December 2019, coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has produced a worldwide panic. Beyond the principal human-to-human transmission method droplet and contact, there is still limited knowledge about possible alternate methods to guide clinical care. Recent studies have observed digestive symptoms in patients with COVID-19,1 possibly because of enrichment infection SARS-CoV-2 gastrointestinal tract, mediated virus...
Introduction: The emerging field of "radiomics" has considerable potential in disease diagnosis, pathologic grading, prognosis evaluation, and prediction treatment response. We aimed to develop a novel radiomics nomogram based on features clinical characteristics that could preoperatively predict early recurrence (ER) intrahepatic cholangiocarcinoma (ICC) after partial hepatectomy. Methods: A predictive model was developed from training cohort comprising 139 ICC patients diagnosed between...
ObjectiveThis study was to investigate the CT quantification of COVID-19 pneumonia and its impacts on assessment disease severity prediction clinical outcomes in management patients.Materials MethodsNinety-nine patients who were confirmed by positive nucleic acid test (NAT) RT-PCR hospitalized from January 19, 2020 February collected for this retrospective study. All underwent arterial blood gas test, routine chest examination, physical examination admission. In addition, follow-up data...
Congenital anomalies of the kidneys or lower urinary tract (CAKUT) are most common causes renal failure in children and account for 25% end-stage disease adults. The spectrum includes agenesis; hypoplasia; dysplasia; supernumerary, ectopic fused kidneys; duplication; ureteropelvic junction obstruction; primary megaureter ureterovesical vesicoureteral reflux; ureterocele; posterior urethral valves. CAKUT originates from developmental defects can occur isolation as part other syndromes. In...
Non-clear cell renal carcinomas (non-ccRCCs) encompass diverse malignant and benign tumors. Refinement of differential diagnosis biomarkers, markers for early prognosis aggressive disease, therapeutic targets to complement immunotherapy are current clinical needs. Multi-omics analyses 48 non-ccRCCs compared with 103 ccRCCs reveal proteogenomic, phosphorylation, glycosylation, metabolic aberrations in RCC subtypes. RCCs high genome instability display overexpression IGF2BP3 PYCR1. Integration...
Treatment decisions for an incidental renal mass are mostly made with pathologic uncertainty. Improving the diagnosis of benign masses and distinguishing aggressive cancers from indolent ones is key to better treatment selection. We analyze 13261 pre-operative computed tomography (CT) volumes 4557 patients. Two multi-phase convolutional neural networks developed predict malignancy aggressiveness masses. The first diagnostic model designed achieves area under curve (AUC) 0.871 in prospective...
PURPOSE: To evaluate diffusion-weighted magnetic resonance (MR) imaging for monitoring tumor response in rats after administration of combretastatin A4 phosphate. MATERIALS AND METHODS: Study protocol was approved by local ethical committee animal care and use. Rhabdomyosarcomas implanted subcutaneously both flanks 17 were evaluated with 1.5-T MR unit using four-channel wrist coil. Transverse T2-weighted fast spin-echo sequences, T1-weighted sequences before gadodiamide administration,...
Human MxA, an interferon-inducible cytoplasmic dynamin-like GTPase, possesses antiviral activity against multiple RNA viruses. Recently, MxA has also been demonstrated to have the hepatitis B virus (HBV), a well-known DNA responsible for acute and chronic liver disease in humans. We investigated molecular mechanism anti-HBV of MxA. Our results that HepG2.2.15 cells, GTPase independently suppressed production surface antigen HBV without changing level core (HBcAg) distribution mRNA....
Background/Aims: To investigate the effects of emodin on concanavalin A (Con A)-induced hepatitis in mice and to elucidate its underlying molecular mechanisms. Methods: fulminant model was established successfully by intravenous administration Con (20 mg/kg) male Balb/c mice. Emodin administered gavage before after injection. The levels pro-inflammatory cytokines chemokines, numbers CD4+ F4/80+ cells infiltrated into liver, amounts phosphorylated p38 MAPK NF-γB mouse livers RAW264.7 EL4 were...
With the increasingly strict diesel standards in countries of world, deep processing oil to ultralow sulfur levels is receiving more and attention. This paper mainly reviews reaction mechanism, catalysts, process conditions hydrodesulfurization, it provides new research directions for producing (ULSD). In terms sterically hindered sulfides, nitrides, aromatic compounds, hydrogen sulfide affect direct desulfurization hydrogenate pathways hydrodesulfurization varying degrees. order eliminate...
We aimed to identify imaging biomarkers assess predictive capacity of radiomics nomogram regarding treatment response status (responder/non-responder) in patients with advanced NSCLC undergoing anti-PD1 immunotherapy.197 eligible histologically confirmed were retrospectively enrolled from nine hospitals. carried out a characterization target lesions (TL) approach and largest lesion (LL) on baseline first follow-up (TP1) CT data. Delta-radiomics feature was calculated as the relative net...
Abstract Background and Aims: Th17 cells have been shown to mediate host defensive mechanisms in various infections, but their role HBV infection humans has not well characterized. In this study, we analyzed the frequency cytokines secretion of circulating infected patients with different statuses, also evaluated potential association levels liver injury. Methods: The study population consisted 133 subjects, including 40 mild chronic hepatitis B (CHB) patients, 37 severe CHB 20 acute (AHB)...
The scaffold protein IQGAP1 shows elevated levels in several cancer types, but its expression hepatocellular carcinoma is unknown. We found that 58% of human tissue samples had increased compared to adjacent normal tissue. Overexpressing raised the vivo tumorigenicity cells, and forced overexpression vitro stimulated cell proliferation. Cell growth was reduced by knockdown or mutation IQGAP1, treatment cells with a phosphotidylinositol 3-kinase inhibitor. To determine mechanism which...
Abstract Background and objective T-cell immunoglobulin domain mucin domain-containing molecule-3 (Tim-3) represents a novel mechanism of dysfunction in chronic viral diseases. However, the role Tim-3 pathogenesis hepatitis B (CHB) is not well understood. We investigated expression on peripheral T cell subsets analyzed relationship between disease progression HBV infection. Methods blood samples were obtained from CHB patients (n = 40), including 23 with moderate [MCHB] 17 severe [SCHB]....