A5103021937- Carcinogens and Genotoxicity Assessment
- Electromagnetic Fields and Biological Effects
- Effects and risks of endocrine disrupting chemicals
- DNA Repair Mechanisms
- Pelvic and Acetabular Injuries
- Hepatitis B Virus Studies
- Spinal Fractures and Fixation Techniques
- Advanced Glycation End Products research
- Effects of Radiation Exposure
- Hepatitis C virus research
- Immune Response and Inflammation
- Connexins and lens biology
- Heavy Metal Exposure and Toxicity
- Hip and Femur Fractures
- Glaucoma and retinal disorders
- Immune cells in cancer
- Macrophage Migration Inhibitory Factor
- Radiation Effects and Dosimetry
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Safe Handling of Antineoplastic Drugs
- Liver Disease and Transplantation
- Ophthalmology and Visual Impairment Studies
- Chemical Safety and Risk Management
- Toxic Organic Pollutants Impact
Sichuan University
2023-2024
Zhejiang University
2010-2023
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2023
University of Electronic Science and Technology of China
2023
Cixian People's Hospital
2023
Second Affiliated Hospital of Zhejiang University
2023
Ningbo Medical Center Lihuili Hospital
2023
Princeton University
2023
Shandong Provincial Hospital
2011-2016
Shandong University
2011-2016
Hemoglobin is released from lysed RBCs in numerous clinical settings. High mobility group box 1 (HMGB1) a nuclear and cytosolic DNA-binding protein injured cells that has been shown to play an important role inducing inflammation. Because both of these endogenous molecules are frequently present sites necrosis inflammation, we studied their interaction on the activation macrophages. We report this article hemoglobin HMGB1 synergize activate mouse macrophages release significantly increased...
Background/Aims: To investigate the effects of emodin on concanavalin A (Con A)-induced hepatitis in mice and to elucidate its underlying molecular mechanisms. Methods: fulminant model was established successfully by intravenous administration Con (20 mg/kg) male Balb/c mice. Emodin administered gavage before after injection. The levels pro-inflammatory cytokines chemokines, numbers CD4+ F4/80+ cells infiltrated into liver, amounts phosphorylated p38 MAPK NF-γB mouse livers RAW264.7 EL4 were...
Purpose: The pathological mechanisms underlying cataract formation remain largely unknown on account of the lack appropriate in vitro cellular models. aim this study is to develop a stable system for human lens regeneration using pluripotent stem cells. Methods: Isolated urinary cells were infected with four Yamanaka factors generate induced (UiPSCs), which differentiate into progenitor and lentoid bodies (LBs). expression lens-specific markers was examined by real-time PCR, immunostaining,...
The purpose of this study was to use finite element analysis compare the biomechanical characteristics after lateral locking plate (LLP) or LLP with a medial anatomical (LLP-MLP) fixation proximal humeral fractures an unstable column.First, 3-dimensional, model developed. Next, and LLP-MLP implants were instrumented into fracture models. Compressive rotational loads then applied humerus determine characteristics. Both normal osteoporotic simulated using 2 internal methods each under 7...
Genetic damage in workers occupationally exposed to an antineoplastic drug was studied using the micronucleus (MN) test, comet assay, hprt gene mutation assay and TCR assay. The subjects were divided into two groups: (i) 21 from a plant producing methotrexate (MTX); (ii) controls matched according age, gender smoking. Fresh blood samples collected controls. results of MN test showed that mean micronuclei rate (MNR) micronucleated cell (MCR) 10.10 ± 0.95‰ 8.05 0.75‰, respectively, which...
Choroidal neovascularization (CNV) is a major cause of vision loss in many retinal diseases. Hypoxia determined to be key inducer CNV and hypoxia-inducible factor-1 (HIF-1) an important transcription factor. Epithelial-mesenchymal transition (EMT) the synthesis proangiogenic cytokines make great contributions development CNV. In present study, role HIF-1α signaling regulation angiogenin (ANG) expression EMT hypoxic pigment epithelial cells was investigated. A significant elevation ANG level...
To investigate the influence of 1.8-GHz radiofrequency fields (RFs) Global System for Mobile Communications on DNA damage, intracellular reactive oxygen species (ROS) formation, cell cycle, and apoptosis in human lens epithelial cells (hLECs) whether effects induced by RF could be blocked superposing electromagnetic noise.After 24-hour intermittent exposure at specific absorption rate 1 W/kg, 2 3 4 damage hLECs was examined alkaline comet assay immunofluorescence microscope detection...