A5100388604- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Multiple Myeloma Research and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Lymphocytic Leukemia Research
- Eosinophilic Disorders and Syndromes
- Renal Diseases and Glomerulopathies
- CNS Lymphoma Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Polyomavirus and related diseases
- Pancreatitis Pathology and Treatment
- Platelet Disorders and Treatments
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Reproductive System and Pregnancy
- Glioma Diagnosis and Treatment
- Blood groups and transfusion
- Head and Neck Cancer Studies
- Chronic Myeloid Leukemia Treatments
- Hereditary Neurological Disorders
- HIV-related health complications and treatments
- IgG4-Related and Inflammatory Diseases
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
National Health and Family Planning Commission
2018-2025
Peking Union Medical College Hospital
2016-2025
Public Health Clinical Center of Chengdu
2025
People's Liberation Army 401 Hospital
2024
Chinese People's Liberation Army
2024
Fujian Medical University
2019-2023
Chinese PLA General Hospital
2022
Weatherford College
2020-2022
Peking University
2022
This study aimed to establish an effective prognostic nomogram with or without plasma Epstein-Barr virus DNA (EBV DNA) for nondisseminated nasopharyngeal carcinoma (NPC). The was based on a retrospective of 4630 patients who underwent radiotherapy chemotherapy at Sun Yat-sen University Cancer Center from 2007 2009. predictive accuracy and discriminative ability the were determined by concordance index (C-index) calibration curve compared EBV current staging system. results validated using...
Repair deficiency after endometrial injury is an important reason for intra-uterine adhesions, amenorrhea, and infertility in females. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation effective repairing the damaged endometrium. However, possibility of using umbilical cord-derived MSCs (UC-MSCs) to treat rarely reported. Ethanol (95%) was injected into rat uterus establish a model injury. UC-MSCs were through tail vein, either as single, twice, or thrice administration....
Abstract Early diagnosis of primary central nervous system lymphoma (PCNSL) represents a challenge, and cerebrospinal fluid (CSF) cytokines may be diagnostic biomarkers for PCNSL. We used an electrochemiluminescence immunoassay to measure interleukin (IL)-10, IL-6, IL-8 tumor necrosis factor α (TNF-α) in the CSF 22 B cell PCNSL patients 80 with other CNS diseases. IL-10 was significantly higher than control group (median 74.7 pg/ml vs < 5.0 pg/ml, P 0.000). Using cutoff value 8.2...
Castleman disease (CD) is a group of rare and heterogenous lymphoproliferative disorders including unicentric CD (UCD), human herpesvirus-8(HHV-8)-associated multicentric (HHV8-MCD), HHV-8-negative/idiopathic (iMCD). Knowledge mainly comes from case series or retrospective studies, but the inclusion criteria these studies vary because Disease Collaborative Network (CDCN) diagnostic for iMCD UCD were not available until 2017 2020, respectively. Further, guidelines have been systematically evaluated.
Summary Idiopathic multicentric Castleman disease (iMCD) is subclassified into iMCD‐thrombocytopenia, anasarca, reticulin fibrosis, renal dysfunction, organomegaly (TAFRO) and iMCD‐not otherwise specified (NOS) according to the Disease Collaborative Network (CDCN) consensus criteria. With a deeper understanding of iMCD, group patients with iMCD‐NOS characterised by polyclonal hypergammaglobulinaemia, plasmacytic/mixed‐type lymph node histopathology thrombocytosis has attracted attention....
Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare plasma dyscrasia without standard treatment. This phase II prospective trial evaluates the safety response of 12 cycles low dose lenalidomide (10 mg) plus dexamethasone (Rdex) in patients with newly diagnosed POEMS syndrome. Forty-one (28 men) were enrolled median age at diagnosis was 49 years (range, 21-70 years). Twenty-one (46%) achieved complete hematologic neurologic rate...
Adult Langerhans cell histiocytosis (LCH) remains poorly defined. We retrospectively studied 266 newly diagnosed LCH patients to understand the clinical presentation, treatment, and prognosis of adult LCH. The median age at diagnosis was 32 years (range, 18-79 years). At time diagnosis, 40 had single lesions within a system, 18 pulmonary LCH, 26 multiple system (SS-m), 182 multisystem disease (MS). most common organ involved in MS bone (69.8%), followed by pituitary (61.5%) lung (61.0%)....
Abstract The endometrium plays a critical role in embryo implantation and pregnancy, thin uterus is recognized as key factor failure. Umbilical cord mesenchymal stem cells (UC-MSCs) have attracted interest for the repair of intrauterine adhesions. current study investigated rats using UC-MSCs mechanisms involved. Rats were injected with 95% ethanol to establish model endometrium. randomly divided into normal, sham, model, groups. Endometrial morphological alterations observed by...
POEMS syndrome is a rare plasma cell dyscrasia. This study compared the responses to and survival of 347 patients given three first-line treatment regimens: autologous stem transplantation (ASCT, N = 165) melphalan + dexamethasone (MDex, 79), or lenalidomide (LDex, 103). After median 45-month follow-up, overall hematologic complete remission (CRH) was 46.4%, vascular endothelial growth factor (CRV) 55.1%, neurological (RN) 93.8%. CRH better with ASCT (49.7%) than MDex (37.7%, p 0.001). CRV...
Gestational diabetes mellitus (GDM) is a disease that changes the function of microvascular placenta. MicroRNA (miRNA) expression in placenta may contribute to pathogenesis GDM. Here, we evaluate role and miR-29b development This study discovered was lower placentas derived from patients with GDM than control placentas. MiR-29b over-expression inhibited cell growth migration, knockdown promoted migration. Then predicted confirmed HIF3A direct target two specific binding sites at recognition...
Anti-B-cell maturation antigen (BCMA) chimeric receptor T-cell (CAR T) therapy showed remarkable efficacy in patients with relapsed or refractory multiple myeloma (RRMM). This phase 1 dose-escalation and expansion study developed C-CAR088, a novel second-generation humanized anti-BCMA CAR therapy, assessed the safety of three dosages C-CAR088 RRMM.
Currently, there is no effective treatment for premature ovarian failure (POF), and stem cell therapy considered the most promising treatment. Human umbilical cord blood mesenchymal cells (hUC-MSCs) have shown good regenerative ability in various diseases, including POF; however, their underlying mechanism dosage POF remain unclear. This study aimed to compare effect of single multiple injections hUC-MSCs on function repair chemotherapy-induced POF.Female mice were intraperitoneally injected...
Relapsed and refractory (R/R) idiopathic Multicentric Castleman disease (iMCD) is a clinical challenge with few treatment options. In this first multicenter, prospective trial which implemented the recently published CDCN response criteria, we evaluated efficacy safety profiles of bortezomib-cyclophosphamide-dexamethasone (BCD) regimen in 24 R/R iMCD patients. By 6 months, 15 patients (62.5%) achieved overall responses; four (16.7%) had stable five (20.8%) suffered from progression disease....
The objective of this study is to verify the prognostic value pretreatment plasma Epstein-Barr viral deoxyribonucleic acid (pEBV DNA) levels in nasopharyngeal carcinoma (NPC) patients complement TNM classification based on application intensity-modulated radiotherapy (IMRT) technique.In total, 1467 staged at I-IVa-b (M0) and treated with IMRT were retrospectively analyzed our cancer center from January 2007 December 2010. Patient survival among different stages EBV DNA compared.Outcome...
This study aimed to evaluate the prognostic value of plasma Epstein–Barr Virus DNA (EBV DNA) for local and regionally advanced nasopharyngeal carcinoma (NPC) patients treated with concurrent chemoradiotherapy in intensity-modulated radiotherapy (IMRT) era. In this observational study, 404 nonmetastatic NPC IMRT cisplatin-based chemotherapy were recruited. Blood samples collected before treatment examination EBV levels. We evaluated association pretreatment levels progression-free survival...