A5050469543- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Geological and Geochemical Analysis
- Renal Diseases and Glomerulopathies
- Tuberous Sclerosis Complex Research
- High-pressure geophysics and materials
- earthquake and tectonic studies
- Neonatal Respiratory Health Research
- Chronic Lymphocytic Leukemia Research
- Polyomavirus and related diseases
- Geochemistry and Elemental Analysis
- Eosinophilic Disorders and Syndromes
- Clusterin in disease pathology
- Nuclear Structure and Function
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transplantation: Methods and Outcomes
- Histiocytic Disorders and Treatments
- Kawasaki Disease and Coronary Complications
- Pulmonary Hypertension Research and Treatments
- Geology and Paleoclimatology Research
- Salivary Gland Disorders and Functions
- IgG4-Related and Inflammatory Diseases
- Toxin Mechanisms and Immunotoxins
- Peptidase Inhibition and Analysis
Peking Union Medical College Hospital
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
ORCID
2024
Tsinghua University
2024
Guangzhou Institute of Geochemistry
2022-2023
Chinese Academy of Sciences
2022-2023
University of Chinese Academy of Sciences
2022-2023
Summary Idiopathic multicentric Castleman disease (iMCD) is subclassified into iMCD‐thrombocytopenia, anasarca, reticulin fibrosis, renal dysfunction, organomegaly (TAFRO) and iMCD‐not otherwise specified (NOS) according to the Disease Collaborative Network (CDCN) consensus criteria. With a deeper understanding of iMCD, group patients with iMCD‐NOS characterised by polyclonal hypergammaglobulinaemia, plasmacytic/mixed‐type lymph node histopathology thrombocytosis has attracted attention....
Relapsed and refractory (R/R) idiopathic Multicentric Castleman disease (iMCD) is a clinical challenge with few treatment options. In this first multicenter, prospective trial which implemented the recently published CDCN response criteria, we evaluated efficacy safety profiles of bortezomib-cyclophosphamide-dexamethasone (BCD) regimen in 24 R/R iMCD patients. By 6 months, 15 patients (62.5%) achieved overall responses; four (16.7%) had stable five (20.8%) suffered from progression disease....
Abstract Background Hereditary bronchiectasis refers to a subset of related genetic mutations, presenting with common clinical features. Historically, diagnosing this condition has been difficult due the inaccessibility diagnostic services coupled lack awareness syndrome. We hypothesize that whole exome sequencing (WES) in patients supporting features, combined non-genetic testing methods, will enhance diagnosis hereditary bronchiectasis. Results In total, 87 features suggestive...
Abstract Background Lymphangioleiomyomatosis (LAM) is a rare neoplastic disorder characterized predominantly by dyspnea, recurrent pneumothorax, chylous effusion and diffuse pulmonary cystic changes in women. Vascular endothelial growth factor-D (VEGF-D) an important biomarker for LAM. Results This study cohort comprised 631 LAM patients investigated the correlations between serum VEGF-D levels clinical manifestations of The median level was 1452pg/ml (820.0-2659pg/ml) among population....
Unicentric Castleman disease (UCD) is a rare lymphoproliferative disorder presenting as single nodal mass with characteristic histopathology. Patients UCD are typically asymptomatic normal laboratory markers, whereas patients multicentric (MCD) demonstrate lymphadenopathy and cytokine storm-induced systemic inflammatory symptoms. This retrospective analysis of 116 cases identified 19 (16.4%) an MCD-like state (UCD-MIS). We compared treatments outcomes between UCD-MIS UCD-non-MIS to evaluate...
Large-scale N-S shortening induced by India-Asia convergence caused the formation of numerous E-W−trending mountain ranges in Tibet. However, mechanism(s) N-S−trending remains elusive. We report on a felsic magmatic belt located along Yardoi-Kongbugang flank Cona rift eastern Tethyan Himalaya. Zircon and monazite geochronology whole-rock geochemistry revealed three epochs middle- to lower-crustal anatexis beneath at ca. 47−42 Ma, 35−34 24−14 Ma. The mid-Eocene early Oligocene granitoids show...
Abstract The origins of Cenozoic granites in the Himalaya are key to understanding evolution Himalayan orogen. However, it is unclear whether these represent primary melts, and nature their magma source controversial. Here, we present a systematic element Sr–Nd–B–Mo isotope study from Yardoi area eastern Tethyan Himalaya, China. These can be divided into two groups: mid‐Eocene porphyritic two‐mica with low SiO 2 contents (65.9−69.6 wt.%) adakitic geochemical signatures, Miocene equigranular...
BackgroundPrevious studies about multicentric Castleman disease-associated pulmonary manifestations have been limited by small cohorts and not following the Disease Collaborative Network classification criteria of disease. The in idiopathic disease-not otherwise specified (iMCD-NOS), a distinct clinical phenotype criteria, reported.Research QuestionWhich abnormalities iMCD-NOS are advanced which reversible after effective treatment?Study Design MethodsPatients diagnosed with involvement were...
Abstract Recycling of molybdenum isotopes in continental subduction zones remains debated. In this contribution, we re‐visit the Mo isotope compositions Sailipu post‐collisional ultrapotassic rocks Himalaya‐southern Tibet orogen. These have very varying δ 98/95 values −0.66 to −0.07‰ and Mo/Ce ratios 0.0008–0.005, which are lower than those mid‐ocean ridge basalts (MORB; = −0.20 ± 0.06‰, 0.03) oceanic subduction‐related (i.e., mantle source involving fluids, residual slab, or sediments)...
Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare interstitial lung disease. COVID-19 associated with worse prognosis in previous diseases patients. But the of aPAP patients after infection unclear. In December 2022, China experienced large-scale outbreak Omicron variant SARS-CoV-2. this study, we aim to explore clinical outcomes infected COVID-19.A total 39 were included study. 30.77% had decrease oxygen saturation infection. We compared two groups or without decreased and found...
<title>Abstract</title> Background Lymphangioleiomyomatosis (LAM) is a rare lung disease that predominantly affects women and can lead to severe respiratory complications. The impact of COVID-19 on LAM patients, particularly regarding the use mammalian target rapamycin (mTOR) inhibitors, remains poorly understood. This study investigates clinical outcomes patients with evaluates role sustained mTOR inhibition in outcomes. Results Our cohort included 186 COVID-19. Prior infection, 72.6% were...
To identify radiological characteristics that could help differentiate cystic lung diseases between primary Sjögren syndrome (pSS) and idiopathic multicentric Castleman disease (iMCD).
<title>Abstract</title> Background Lymphangioleiomyomatosis (LAM) is a rare lung disease that predominantly affects women and can lead to severe respiratory complications. The impact of COVID-19 on LAM patients, particularly regarding the use mechanistic target rapamycin (mTOR) inhibitors, remains poorly understood. This study investigated clinical outcomes patients with evaluated effect sustained mTOR inhibition outcomes. Results Our cohort included 186 COVID-19. Prior infection, 72.6% were...
Adakitic rocks at continental collisional zones have important implications for understanding the mechanism of crustal reworking. The Himalayan–Tibetan orogen, built by India–Asia collision and Indian plate subduction, is one most prominent Cenozoic continent–continent zones, post-collisional adakitic widely occur in Lhasa block southern Tibet. Numerous studies suggested that granitoids eastern were derived from partial melting a juvenile crust mantle-derived ultrapotassic magmas...