A5049806572- Renal cell carcinoma treatment
- Head and Neck Cancer Studies
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Kruppel-like factors research
- Renal and related cancers
- Head and Neck Surgical Oncology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Cancer Immunotherapy and Biomarkers
- Radiation Therapy and Dosimetry
- Cancer, Hypoxia, and Metabolism
- Hepatitis C virus research
- MRI in cancer diagnosis
- Lung Cancer Treatments and Mutations
- Hepatitis B Virus Studies
- Cancer Cells and Metastasis
- Fibroblast Growth Factor Research
- Tracheal and airway disorders
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Chemokine receptors and signaling
Huazhong Agricultural University
2023-2025
Sun Yat-sen University
2014-2023
Sun Yat-sen University Cancer Center
2014-2023
Cancer Genetics (United States)
2002-2023
State Key Laboratory of Agricultural Microbiology
2023
State Key Laboratory of Oncology in South China
2014-2020
Bioengineering Center
2013
National Center for Genetic Engineering and Biotechnology
2013
Van Andel Institute
2002-2012
Corewell Health Blodgett Hospital
2009
To evaluate which patients with nasopharyngeal carcinoma (NPC) obtained the greatest benefits from detection of distant metastasis [(18)F]fluorodeoxyglucose positron emission tomography and computed (PET/CT) combined plasma Epstein-Barr virus (EBV) DNA levels.Consecutive NPC were prospectively enrolled. PET/CT, conventional work-up (CWU), quantification EBV performed before treatment. The accuracy these strategies for metastases was assessed. costs diagnostic compared.Eighty-six (14.8%) 583...
Abstract Objectives: Nasopharyngectomy is the primary treatment for locally recurrent nasopharyngeal carcinoma (rNPC). However, oncological nasopharyngectomy difficult to achieve, even using extranasal surgical approaches, with potential risks of severe functional disabilities and serious complications. This report introduces an innovative, minimally invasive, oncological, endoscopic nasopharyngectomy. Methods: Between October 2004 January 2008, 37 rNPC patients received nasopharyngectomy,...
Due to the occult anatomic location of nasopharynx and frequent presence adenoid hyperplasia, positive rate for malignancy identification during biopsy is low, thus leading delayed or missed diagnosis nasopharyngeal malignancies upon initial attempt. Here, we aimed develop an artificial intelligence tool detect under endoscopic examination based on deep learning.An images-based detection model (eNPM-DM) consisting a fully convolutional network inception architecture was developed fine-tuned...
Urothelial carcinoma of the renal pelvis is a deadly disease with an unclear tumorigenic mechanism. We conducted gene expression profiling on set human tumors this type and identified phosphatidylinositol 3-kinase (PI3K)/AKT activation signature in 76.9% (n = 13) our samples. Sequence analysis found both activating mutations PIK3CA (13.6%, n 22) loss heterozygosity at PTEN locus (25%, 8). In contrast, none other subtypes kidney neoplasms (e.g., clear-cell cell carcinoma) harbored 87; P <...
Abstract Background Endoscopic nasopharyngectomy is a new salvage treatment for locally recurrent nasopharyngeal carcinoma (NPC). However, how to resurface the defects in endoscopic endonasal approaches avoid persistent postoperative headache, best of our knowledge, has not been reported. Methods From September 2009 August 2010, we used modified posterior pedicle nasal septum and floor mucoperiosteum flap (nasal flap, NSFF) after 12 patients with NPC. Most mucoperiosteum, except pedicle, was...
We aimed to determine the prognostic values of 39 circulating cytokines in Chinese patients with metastatic colorectal cancer (CRC) and develop a novel cytokine-based classifier (CBPC) for prediction. A total 176 were divided into two cohorts based on date first-line chemotherapy. The first 99 cases assigned training cohort, remaining 77 validation cohort. Thirty-nine simultaneously analyzed patient serum samples using multiplex bead-based Luminex technology. used support vector...
To compare intensity-modulated radiotherapy (IMRT) with cisplatin (CDDP) versus cetuximab (CTX) and nimotuzumab (NTZ) for Stage II-IVb Nasopharyngeal Carcinoma (NPC). A total of 1,837 patients stage NPC who received IMRT plus CTX or NTZ, CDDP between January 2009 December 2013 were included in the current analysis. Using propensity scores to adjust potential prognostic factors, a well-balanced cohort 715 was created by matching each patient underwent concomitant NTZ/CTX four (1:4). Efficacy...
Abstract Serglycin is a proteoglycan that was first found to be secreted by hematopoietic cells. As an extracellular matrix (ECM) component, serglycin promotes nasopharyngeal carcinoma (NPC) metastasis and serves as independent, unfavorable NPC prognostic indicator. The detailed mechanism underlying the roles of in cancer progression remains clarified. Here, we report knockdown cells inhibited cell sphere formation tumor seeding abilities. downregulation enhanced high-metastasis sensitivity...
Background: The goal of this study was to explore the value adding neoadjuvant chemotherapy (NACT) or adjuvant (ACT) concurrent chemoradiotherapy (CCRT) in patients with nasopharyngeal carcinoma (NPC) different risks treatment failure. Patients and Methods: A total 2,263 eligible stage III–IVb NPC treated CCRT ± NACT ACT were included retrospective study. Distant metastasis–free survival (DMFS), overall survival, progression-free calculated using Kaplan-Meier method differences compared...
Adiponectin is an adipocyte-secreted cytokine that enhances insulin sensitivity and attenuates inflammation. Although circulating adiponectin level often inversely associated with several malignancies, its role in the development of nasopharyngeal carcinoma (NPC) remains unclear. Here, we investigated clinical association between NPC, examined impact adiponectin, as well underlying mechanisms, on NPC growth both vitro vivo.
Zika virus (ZIKV) is a mosquito-borne belonging to the genus Orthoflavivirus, and family Flaviviridae. It commonly presents with febrile-like symptoms, neurological issues, pregnancy complications in humans. Currently, there no commercial vaccine or specific treatment available prevent ZIKV infection. Therefore, controlling epidemic's spread relies on preventing mosquitoes from transmitting virus. Although various studies have explored transmission of between vertebrate hosts, comprehensive...
Hemoglobin (Hb) levels are regarded as an important determinant of outcome in a number cancers treated with radiotherapy. However, for patients intensity modulated radiotherapy (IMRT), information regarding the prognostic value hemoglobin level is scarce. A total 650 nasopharyngeal carcinoma (NPC), enrolled between May, 2005, and November, 2012, were included this study. The significance (anemia or no-anemia) at three different time points was investigated, including before treatment, during...
Abstract Purpose: Previous studies suggest that a cumulative cisplatin dose of 200 mg/m2 might be adequate in the intensity-modulated radiation therapy (IMRT) era for locoregionally advanced nasopharyngeal carcinoma (LANPC). However, two cycles once-every-3-weeks at 100 has never been prospectively compared with standard once-a-week regimen. Patients and Methods: This trial was conducted three hospitals from 2011 to 2016. who met eligibility criteria were recruited (ChiCTR-TRC-12001979)...
Objective To compare survival effects of comprehensive neck dissection (CND) and selective (SND) for patients with nasopharyngeal carcinoma (NPC) only regional failure. Methods A total 294 recurrent T0N1‐3M0 NPC who underwent in Sun Yat‐Sen University Cancer Center, Guangzhou, People's Republic China, between January 1984 February 2014, were enrolled the interaction analyses. Using propensity scores to adjust potential prognostic factors, an additional well‐balanced cohort 210 was...
Abstract Notch pathway is a highly conserved cell signaling system that plays very important roles in controlling multiple differentiation processes during embryonic and adult life. Multiple lines of evidence support the oncogenic role several human solid cancers; however, pleiotropic effects molecular mechanisms inhibition on nasopharyngeal carcinoma (NPC) remain unclear. In this study, we evaluated Notch1 expression NPC (CNE1, CNE2, SUNE1, HONE1, HK1) by real‐time quantitative PCR Western...
Cancer has become a major fatal disease in China. The relatively lower early detection rates for multiple cancer types have been one of the main reasons curative rate China compared with developed countries. To investigate trends over past 5 years city China, 45,260 patients newly diagnosed cancers nasopharynx, lung, thyroid, colorectum, liver, breast, uteral cervix, stomach, esophagus, blood, and kidney from 2016 to 2020 at Sun Yat-sen University Center were evaluated. (stage I disease) all...
Nasopharyngeal carcinoma (NPC) is relatively sensitive to ionizing radiation, and radiotherapy the main treatment modality for non-metastatic NPC. Radiation therapy generates overproduction of reactive oxygen species (ROS), which can cause DNA damage induce apoptosis in tumors, thereby killing malignant cells. Although dietary antioxidant supplementation reduces oxidative stress promotes tumor progression, effects antioxidants on NPC cells upon radiation have not been reported. In present...
Objective: The possible enhancing effect of anlotinib on programmed death receptor ligand (PD-L1) antibody and the efficacy-predicting power PD-L1 in micro-conduit endothelium, including lymphatic endothelial cells (LECs) blood (BECs), were determined to identify patients who would benefit from this treatment. Methods: positivity LECs, BECs, tumor (TCs) was assessed using paraffin sections with multicolor immunofluorescence an investigator’s brochure clinical trial TQB2450 (PD-L1 antibody)...
Insulin-like growth factor binding proteins (IGFBPs) play critical roles in carcinogenesis. This study assessed the impact of IGFBP6 on progression nasopharyngeal carcinoma (NPC). Using immunohistochemical analysis, we found that was differentially expressed primary malignant NPC tissues. Clinical samples were divided into two groups: IGFBP6(+) and IGFBP6(-). Five years follow-up revealed overall survival distant metastasis-free rates significantly higher than IGFBP6(-) group. We also used...