A5002345978- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Aquaculture disease management and microbiota
- Molecular Biology Techniques and Applications
- Animal Genetics and Reproduction
- Genetic factors in colorectal cancer
- Genetic and Kidney Cyst Diseases
- Single-cell and spatial transcriptomics
- RNA regulation and disease
- RNA modifications and cancer
- Asthma and respiratory diseases
- Genetic and phenotypic traits in livestock
- Histone Deacetylase Inhibitors Research
- Reproductive System and Pregnancy
- Cancer-related gene regulation
- Gene expression and cancer classification
- Cerebral Palsy and Movement Disorders
- Neonatal Respiratory Health Research
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Adrenal and Paraganglionic Tumors
Grand Valley State University
2013-2022
Umeå University
2015
Ferris State University
2015
University of Colorado Anschutz Medical Campus
2015
Van Andel Institute
2004-2013
Sun Yat-sen University
2009-2013
Cancer Genetics (United States)
2002-2013
Sun Yat-sen University Cancer Center
2009-2013
National Cancer Center
2013
Indiana University – Purdue University Indianapolis
2013
Abstract We constructed a genetic linkage map for tetraploid derivative species, the rainbow trout (Oncorhynchus mykiss), using 191 microsatellite, 3 RAPD, 7 ESMP, and allozyme markers in three backcross families. The consists of 29 groups with potential arm displacements female due to male-specific pseudolinkage arrangements. Synteny duplicated microsatellite was used identify confirm some previously reported arrangements based upon markers. Fifteen centromeric regions (20 chromosome arms)...
Significant proportions of patients with hamartomatous polyposis or hyperplastic/mixed remain without specific clinical and molecular diagnosis present atypically. Assigning a syndromic is important because it guides management, especially surveillance prophylactic surgery.To systematically classify unexplained by extensive analysis in the context central rereview histopathology results.Prospective, referral-based study 49 unrelated from outside institutions (n = 28) at comprehensive cancer...
Birt-Hogg-Dubé syndrome (BHD) is an autosomal dominant cancer characterised by benign skin tumours, renal and spontaneous pneumothorax. The gene has been mapped to chromosome 17p11.2 recently identified, expressing a novel protein called folliculin. We report the clinical genetic studies of four sporadic BHD cases families with total 23 affected subjects. Haplotype analysis these using linked markers showed they did not share same alleles, excluding common ancestry. Mutation <i>BHD</i>...
The current "gold-standard" for Parkinson's disease (PD) diagnosis is based primarily on subjective clinical rating scales related with motor features. Molecular biomarkers that are objective and quantifiable remain attractive as tools to detect PD prior its onsets.Here, we aimed identify, develop, validate plasma-based circulating microRNA (miRNAs) PD.Global miRNA expressions were acquired from a discovery set of 32 PD/32 controls using microarrays. k-Top Scoring Pairs (k-TSP) algorithm...
Invasive and proliferative phenotypes are fundamental components of malignant disease, yet basic questions persist about whether tumor cells can express both simultaneously and, if so, what their properties. Suitable in vitro models that allow characterization purely invasive limited because proliferation is required for cell maintenance. Here, we describe glioblastoma highly response to hepatocyte growth factor/scatter factor (HGF/SF). From this population, selected subclones were or...
Peroxisome proliferator-activated receptors (PPARα, -β/δ, and -γ) are a subfamily of nuclear that plays key roles in glucose lipid metabolism. PPARγ is the molecular target thiazolidinedione class antidiabetic drugs has many side effects. also activated by long chain unsaturated or oxidized/nitrated fatty acids, but its relationship with medium acids remains unclear even though triglyceride oils have been used to control weight gain glycemic index. Here, we show decanoic acid (DA), 10-carbon...
The Birt-Hogg-Dubé (BHD) disease is a genetic cancer syndrome. responsible gene, BHD, has been identified by positional cloning and thought to be novel tumor suppressor gene. BHD mutations cause many types of diseases including renal cell carcinomas, fibrofolliculomas, spontaneous pneumothorax, lung cysts, colonic polyps/cancers. By combining Gateway Technology with the Ksp-Cre gene knockout system, we have developed kidney-specific mouse model. BHD(flox/flox)/Ksp-Cre mice enlarged kidneys...
Vascular dementia (VaD) is cognitive decline linked to reduced cerebral blood perfusion, yet there are few therapeutic options protect function following cerebrovascular accidents. The purpose of this study was profile gene expression changes unique VaD identify and characterize disease relevant that could offer clues for future direction. Microarray-based profiling validation studies postmortem frontal cortex samples from VaD, Alzheimer disease, age-matched control subjects revealed the...
Chromophobe renal cell carcinoma (chRCC) and oncocytoma are two distinct but closely related entities with strong morphologic genetic similarities. While chRCC is a malignant tumor, usually regarded as benign entity. The overlapping characteristics best explained by common cellular origin, the biologic differences between therefore of considerable interest in terms carcinogenesis, diagnosis clinical management. Previous studies have been relatively limited examining chromophobe RCC. Gene...
Inhibition of lysosome function promotes the anti-inflammatory effects glucocorticoid signaling.
Significance Chromosome instability and its resulting karyotypic heterogeneity make up one of the most striking characteristics human cancers. Yet whether chromosome loss or gain drives tumor progression to metastasis remains unknown. Here we show that clonal populations epithelial cells spontaneously generate mesenchymal variants. These variants have potential for reverting an phenotype. Importantly, successive phenotypic selectively eliminate acquire segments harbor genes encoding...
Clinical application of inhaled glucocorticoids (GCs) has been hampered in the case steroid-resistant severe asthma. To overcome this limitation, we have developed a series highly potent GCs, including VSGC12, VSG158, and VSG159 based on structural insight into glucocorticoid receptor (GR). Particularly, VSG158 exhibits maximal repression lung inflammation is 10 times more than currently most clinical GC, Fluticasone Furoate (FF), murine model More importantly, displays unique property to...
BHD, TP53, and HNF1β on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, nine papillary). Six, thirteen, zero had, respectively mutations, (84% mutations involved chromophobe), suggesting a role for BHD TP53 chromophobe subtype.
Urothelial carcinoma of the renal pelvis is a deadly disease with an unclear tumorigenic mechanism. We conducted gene expression profiling on set human tumors this type and identified phosphatidylinositol 3-kinase (PI3K)/AKT activation signature in 76.9% (n = 13) our samples. Sequence analysis found both activating mutations PIK3CA (13.6%, n 22) loss heterozygosity at PTEN locus (25%, 8). In contrast, none other subtypes kidney neoplasms (e.g., clear-cell cell carcinoma) harbored 87; P <...
Hepatitis B virus (HBV) is a well-known cause of hepatocellular carcinoma (HCC), but the regulators effectively driving production and HCC progression remain unclear. By using genetically engineered mouse models, we show that overexpression hepatocyte growth factor (HGF) accelerated progression, supporting genomic analysis an up-regulated HGF signature associated with poor prognosis in HBV-positive patients. We for both liver regeneration spontaneous development there inclusive requirement...
Are microRNAs (miRs) altered in the eutopic endometrium (EuE) of baboons following induction endometriosis? Induction endometriosis causes significant changes expression eight miRs, including miR-451, baboon as early 3 months disease. Endometriosis is one most common gynecological disorders and chronic pelvic pain infertility women reproductive age. Altered miRs has been reported suggested to play an important role pathophysiology several endometriosis. EuE was obtained from same group...