A5047485754- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Adrenal and Paraganglionic Tumors
- Renal and related cancers
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Urinary and Genital Oncology Studies
- Pituitary Gland Disorders and Treatments
- Hormonal Regulation and Hypertension
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Prostate Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Sexual Differentiation and Disorders
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
Hôpital Cochin
2016-2025
Université Paris Cité
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Centre National de la Recherche Scientifique
2014-2024
Inserm
2007-2024
Institut Cochin
2016-2024
Sorbonne Paris Cité
2013-2023
Délégation Paris 5
2013-2021
Université Sorbonne Paris Nord
2020-2021
Sorbonne Université
2008-2020
Corticotropin-independent macronodular adrenal hyperplasia may be an incidental finding or it identified during evaluation for Cushing's syndrome. Reports of familial cases and the involvement both glands suggest a genetic origin this condition.
Muscle-invasive bladder carcinoma (MIBC) constitutes a heterogeneous group of tumors with poor outcome. Molecular stratification MIBC may identify clinically relevant tumor subgroups and help to provide effective targeted therapies. From seven series large-scale transcriptomic data (383 tumors), we identified an subgroup accounting for 23.5% MIBC, associated shorter survival displaying basal-like phenotype, as shown by the expression epithelial basal cell markers. Basal-like presented...
Succinate dehydrogenase (SDH)-deficient renal carcinoma has been accepted as a provisional entity in the 2013 International Society of Urological Pathology Vancouver Classification. To further define its morphologic and clinical features, we studied multi-institutional cohort 36 SDH-deficient carcinomas from 27 patients, including 21 previously unreported cases. We estimate that 0.05% to 0.2% all are SDH deficient. Mean patient age at presentation was 37 years (range, 14 76 y), with slight...
Abstract Purpose: Selecting patients with metastatic clear-cell renal cell carcinoma (m-ccRCC) who might benefit from treatment targeted tyrosine kinase inhibitors (TKI) is a challenge. Our aim was to identify molecular markers associated outcome in m-ccRCC treated sunitinib. Experimental Design: We performed global transcriptome analyses on 53 primary resected ccRCC tumors developed disease and were first-line also determined chromosome copy-number aberrations, methylation status, gene...
Hereditary leiomyomatosis and renal cell carcinoma syndrome–associated carcinomas (RCC) are difficult to diagnose prospectively. We used immunohistochemistry (IHC) identify fumarate hydratase (FH)-deficient tumors (defined as FH negative, 2-succinocysteine [2SC] positive) in cases diagnosed “unclassified RCC, high grade or with papillary pattern,” “papillary RCC type 2,” from multiple institutions. A total of 124 (from 118 patients) were evaluated by IHC for 2SC. An deficiency was found...
Inhibitory receptors expressed by T cells mediate tolerance to tumor antigens, with coexpression of these exacerbating this dysfunctional state. Using the VectraR automated multiparametric immunofluorescence technique, we quantified intratumoral CD8+ coexpressing inhibitory PD-1 and Tim-3 from patients renal cell carcinoma (RCC). A second validation cohort measured same parameters cytometry. The percentage tumor-infiltrating correlated an aggressive phenotype a larger size at diagnosis....
The angiotensin-converting enzyme (ACE; EC 3.4.15.1 ) gene ( Ace encodes both a somatic isozyme found in blood and several other tissues, including the epididymis, testis-specific (testis ACE) only developing spermatids mature sperm. We recently used targeting to disrupt coding for ACE isozymes mice reported that male homozygous mutants mate normally but have reduced fertility; mutant females are fertile. Here we explore fertility defect. demonstrate is important achieving vivo fertilization...
Purpose Transitional cell carcinoma (TCC) is a pan-urothelial disease characterized by multiplicity. Although little known about the molecular events in upper-tract TCC, similar carcinogenic mechanisms are thought to occur throughout urinary tract. However, we have previously shown that distinct patterns of microsatellite instability upper and lower tract suggesting biologic differences between these tumors. Here investigate extent promoter hypermethylation TCC Patients Methods Tissue was...
We report clinicopathologic features of a large series renal translocation carcinomas from multicentric study. Diagnosis was performed by cytogenetic examination fresh material and/or immunochemistry with antibodies directed against the C-terminal part transcription factor E3 (TFE3) and native EB (TFEB) proteins. Clinical data, follow-up, histologic were assessed. Antibodies CK7, CD10, vimentin, epithelial membrane antigen, AE1-AE3, E-cadherin, alpha-methylacyl-coenzyme A racemase, melan A,...
The aim of this study was to identify high-risk patients for hepatocellular carcinoma (HCC). Among 151 with histologically proven cirrhosis hospitalized from 1987 1990 and prospectively followed-up until June 1994, 31 developed HCC. We assessed the predictive value 22 variables recorded at enrollment HCC occurrence by log rank test Cox proportional hazards model. Six clinical biological summarized information HCC: age > or = 50 years ( P .01), male large esophageal varices (EV) .03),...
The angiotensin II type 1 (AT1) receptor in murine species exists as two isoforms (AT1A and AT1B) encoded by different genes. Both subtypes have a 9/10 homology the coding sequence of their mRNA. We examined organs adult rats (liver, pituitary gland, adrenal kidney, heart, lung) to study differential expression these genes target tissues for II. AT1A AT1B mRNAs were detected situ hybridization using specific riboprobes 3' noncoding region that lowest (approximately 6/10). Only was expressed...
Abstract Pheochromocytomas and paragangliomas (PCCs/PGLs) are neural crest-derived tumours with a very strong genetic component. Here we report the first integrated genomic examination of large collection PCC/PGL. SNP array analysis reveals distinct copy-number patterns associated background. Whole-exome sequencing shows low mutation rate 0.3 mutations per megabase, few recurrent somatic in genes not previously DNA methylation arrays miRNA identify changes expression clusters strongly...
No AccessJournal of UrologyAdult urology1 May 2007Behavior Urothelial Carcinoma With Respect to Anatomical Location J.W.F. Catto, D.R. Yates, I. Rehman, A.R. Azzouzi, J. Patterson, M. Sibony, O. Cussenot, and F.C. Hamdy CattoJ.W.F. Catto Academic Urology Unit, University Sheffield, United Kingdom More articles by this author , YatesD.R. Yates RehmanI. Rehman AzzouziA.R. Azzouzi Service d’Urologie, Centre Hospitalier Universitaire d’Angers, Angers, Paris, France PattersonJ. Patterson...
A unique renal neoplasm characterized by eosinophilic cytoplasm and solid cystic growth was recently reported in patients with tuberous sclerosis complex (TSC). We searched multiple institutional archives consult files an attempt to identify a sporadic counterpart. identified 16 morphologically identical cases, all women, without clinical features of TSC. The median age 57 years (range, 31 75 y). Macroscopically, tumors were tan had macrocystic (12) or only appearance (4). Average tumor size...
Papillary renal cell carcinomas (pRCC) are the most common nonclear RCC subtype. Germline mutations of MET oncogene at 7q31 have been detected in patients with hereditary type I pRCC and 13% sporadic pRCC. Recent report inhibition strengthened role c-Met across pRCC.We collected 220 frozen samples through French Network quality controlled for percentage malignant cells >70%. Gene expression was assessed on 98 using human whole-genome Agilent 8 × 60K arrays. Copy number alterations were...
Eosinophilic solid and cystic renal cell carcinoma (ESC RCC) has been recently described as a unique indolent neoplasm, found in female patients with without tuberous sclerosis complex. Although ESC RCC distinct morphology frequent CK20 reactivity, its molecular karyotype previously studied only few cases. We identified 19 from multiple institutions; all were individuals clinical features of Molecular karyotyping was performed 13 cases (12 informative result). The median age 55 years (range:...
An emerging group of high-grade renal cell carcinomas (RCCs), particularly arising in the hereditary leiomyomatosis carcinoma syndrome (HLRCC), show fumarate hydratase ( FH ) gene mutation and loss function. On basis similar cytomorphology clinicopathologic features between these tumors cases described as tubulocystic with poorly differentiated foci (TC-PD) infiltrative adenocarcinoma, we hypothesized a relationship entities. First, 29 RCCs morphology TC-PD were identified retrospectively...
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors. Whereas most PPGLs benign, up to 20% may become metastatic with SDHB- FH-mutated tumors showing the higher risk. We aimed at determining contribution of immortalization mechanisms progression.Experimental Design: Immortalization were investigated in 200 To identify telomerase (+) tumors, we analyzed genomic alterations leading transcriptional activation TERT comprising promoter mutations, hypermethylation gain copy...
Angiotensin converting enzyme exists in two different isoforms, somatic and germinal, whose respective distributions intracellular localizations have not been precisely determined. The differing biochemical molecular characteristics of the isozymes allowed preparation antibodies specific for each angiotensin isoforms nucleic acid probes, one which was germinal isoform. Immunohistochemistry situ hybridization were used to determine cell distribution of, respectively, their corresponding...
The gene cyclin-dependent kinase inhibitor 2A (CDKN2A) is frequently inactivated by deletion in bladder carcinoma. However, its role tumourigenesis remains unclear. We investigated the of CDKN2A urothelial carcinogenesis, as a function FGFR3 mutation status, marker for one two pathways tumour progression, Ta pathway. studied 288 carcinomas: 177 non-muscle-invasive (123 Ta, 54 T1) and 111 muscle-invasive (T2-4) tumours. copy number was determined multiplex ligation-dependent probe...