A5100733084- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Traditional Chinese Medicine Analysis
- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Advanced Fluorescence Microscopy Techniques
- Vitamin D Research Studies
- Bone health and osteoporosis research
- Traditional Chinese Medicine Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Image Processing Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Phytochemistry and Biological Activities
- Cancer Mechanisms and Therapy
- Chromatography in Natural Products
- Bone Metabolism and Diseases
- Cell death mechanisms and regulation
- Bone health and treatments
- Metabolomics and Mass Spectrometry Studies
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Melanoma and MAPK Pathways
- Cardiac Health and Mental Health
- Natural product bioactivities and synthesis
Guangxi University
2021-2025
Guangxi University of Chinese Medicine
2021-2025
Dalian Medical University
2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
Children's Hospital of Chongqing Medical University
2025
North China University of Science and Technology
2025
Huazhong University of Science and Technology
2024
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2024
Wuhan University
2012-2024
Abstract Background Astrocytes are crucial regulators in the central nervous system. Abnormal activation of astrocytes contributes to some behavior deficits. However, mechanisms underlying effects remain unclear. Here, we studied A1 and their contribution murine Methods were induced by treatment with lipopolysaccharide (LPS) vitro. The functional phenotype was determined quantitative RT-PCR, ELISA, immunohistochemistry. To assess role vivo, mice injected intraperitoneally LPS. Then,...
The aim of this paper was to study the effect long-term supervised exercise-induced weight maintenance on metabolic risk factors and physical fitness in obese children early puberty. A total 49 aged 12-14 years were divided into control exercise groups. group accepted intervention by a professional sports teacher for 9 12 months. All participants both groups received health education once every 3 Anthropometry fasting serum lipids, glucose, insulin homeostatic model assessment resistance...
To explore whether plasma fatty acids and SNPs in the acid desaturase (FADS) gene associated with type 2 diabetes (T2D) coronary artery disease (CAD).In this cross-sectional study, we utilized gas chromatography-mass spectrometric analysis high-resolution melting method to detect respectively (rs174537G>T, rs174616C>T, rs174460T>C, rs174450A>C) 234 T2D, 200 CAD, 185 T2D&CAD patients, 253 healthy controls.We found that patients had highest arachidonic acid, dihomo-gamma-linolenic delta-6...
ObjectiveTo explore the effect of vitamin D on turnover articular cartilage with ovariectomy (OVX) induced OA, and to investigate transforming growth factor-β1 (TGF-β1) as a possible underlying mechanism mediated by 1α,25(OH)2D3.DesignSixty-six rats were randomly allocated into seven groups: sham plus control diet (SHAM+CTL), OVX+CTL diet, D-deficient (VDD) OVX+VDD three groups ovariectomized treated different doses 1α,25(OH)2D3. The erosion levels serum 17β-estradiol, 1α,25(OH)2D3...
Federated learning is a privacy-preserving distributed machine paradigm. However, due to client data heterogeneity, the global model trained by traditional federated averaging algorithm often exhibits poor generalization ability. To mitigate impact of some existing research has proposed clustered learning, where clients with similar distributions are grouped together reduce interference from dissimilar clients. since distribution unknown, determining optimal number clusters difficult,...
Ipomoea pes-caprae (L.) Sweet (Convolvulaceae) is a commonly used marine Chinese medicine in the coastal areas of southern China. Traditionally, it has been treatment rheumatoid arthritis (RA). However, mechanism action against RA remains unclear. This study aimed to explore water extract (IPE) through serum metabolomics and network pharmacology. Rat models with wind-dampness cold bi-syndrome (WCM) heat (WHM) were established evaluate therapeutic effect IPE RA. Ultra-high performance liquid...
Accurate estimation of ground-level ozone (O₃) concentration is crucial for assessing its health impacts and devising effective control strategies. Traditional methods relying on polar-orbit satellites offer limited, single-time measurements, failing to capture the significant diurnal variability O₃. This study utilizes Geostationary Environment Monitoring Spectrometer (GEMS), a next-generation geostationary satellite, retrieve hourly O₃ concentrations. The GEMS...
Abstract Purpose: Previous studies suggest that a cumulative cisplatin dose of 200 mg/m2 might be adequate in the intensity-modulated radiation therapy (IMRT) era for locoregionally advanced nasopharyngeal carcinoma (LANPC). However, two cycles once-every-3-weeks at 100 has never been prospectively compared with standard once-a-week regimen. Patients and Methods: This trial was conducted three hospitals from 2011 to 2016. who met eligibility criteria were recruited (ChiCTR-TRC-12001979)...
The extracellular matrix of cartilage primarily constitutes collagen and aggrecan. Cartilage degradation starts with aggrecan loss in osteoarthritis (OA). Vitamin D (VD) plays an essential role several inflammation-related diseases can protect the during OA. present study focused on VD turnover human articular chondrocytes treated tumor necrosis factor α (TNF-α) possible mechanism. Treatment different doses periods intervention TNF-α TGF-β1 receptor (TGFβR1) inhibitor SB525334 were...
Free fatty acids (FFAs) play importance roles in the development of diabetes and cardiovascular diseases. We measured serum FFA levels from type 2 mellitus (T2DM) acute myocardial infarction (AMI) patients assay correlation between related factors. The present study was undertaken to investigate a possible relation changes free acid concentration with mellitus. population consisted 540 healthy individuals 103 T2DM, 59 AMI 21 volunteers. Serum FFAs were high pressure liquid chromatography....
A study was conducted to determine the effects of different levels apple juice concentrate (AJC), blackcurrant (BCC) and pectin on moisture content, water activity, color, texture ascorbic acid content apple-blackcurrant fruit leather using response surface methodology. The results showed increased with increasing level greater increases at higher AJC BCC while activity level, low levels, but decreasing AJC, high levels. chroma decreased lower values middle level. puncturing force a value...
6006 Background: In intensity-modulated radiotherapy (IMRT) era, concurrent chemoradiotherapy (CCRT) with either every three week (ETW) or once a (OAW) cisplatin is accepted practice for locoregionally advanced nasopharyngeal carcinoma (LANPC). However, ETW and OAW were never prospectively compared in phase 3 clinical trials. This study to assess the efficacy toxicity profiles of CCRT versus schedule cisplatin. Methods: We conducted an open-label multicentre randomised controlled trial...
Preliminary evidence based on clinical observations suggests that meditative exercise may offer potential benefits for patients with chronic heart failure (CHF). Cardiac rehabilitation (CR), as a class-IA indication in practice guidelines, has been established an effective strategy to improve quality of life and prognosis CHF patients. Baduanjin is important component traditional Chinese Qigong exercises. However, its have not rigorously tested. We sought investigate whether Baduanjin,...
While Baduanjin, a traditional Chinese mind-body exercise, has shown potential health benefits, its efficacy in improving outcomes for heart failure patients with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) not been well documented. We aimed to investigate the adjunctive impact of Baduanjin on exercise capacity and quality life HFmrEF/HFpEF.
Low levels of serum vitamin D have been shown to accelerate progression osteoarthritis. However, the role in articular cartilage degradation and osteoarthritis development is still unclear. This study investigated effects on by testing matrix metalloproteinase (MMPs) activities using rat deficiency model at animal level chondrocytes cell level. The vivo showed increased expressions MMP-9 MMP-13 cartilage, increase was inhibited 1α,25(OH)2D3 supplementation. production induced tumor necrosis...
Osteosarcoma is the most common primary malignant bone tumor in clinic. It more children and adolescents. has high malignancy, early metastasis rate, rapid disease progression, mortality. Although past years have witnessed great improvement treatments of osteosarcoma, there remains a long way to go. MicroRNAs affect biological behaviors such as proliferation by regulating their target genes. In this study, we investigated role mechanism miR-384 osteosarcoma. Quantitative real-time polymerase...
Refocusing after Scanning using Helical phase engineering (RESCH) microscopy has previously been demonstrated to provide volumetric information from a single 2D scan. However, the practical application of this method is challenging due its limited image acquisition speed and spatial resolution. Here, we report on combination RESCH multifocal structured illumination (MSIM) improve A mask introduced modulate conventional point spread function (PSF) double-helix PSF (DH-PSF), which provides...
Purpose: Several novel genetic variants for type 2 diabetes mellitus (T2DM) have been identified through genome-wide association studies (GWAS). A case-controll study was performed to investigate the of five new European or South Asian GWAS-derived susceptibility loci with T2DM in a Chinese population. Methods: Five single nucleotide polymorphisms (SNPs) were genotyped: rs3923113 near GRB14, rs16861329 ST6GAL1, rs1802295 VPS26A, rs7178572 HMG20A, and rs231362 KCNQ1, by high-resolution...
Single-molecule localization methods play a vital role in localization-based super-resolution fluorescence microscopy. However, it is difficult for conventional schemes based on the Gaussian fitting to locate overlapped high-density fluorescent emitters. Currently, spatial domain, compressive-sensing-based algorithm (CSSTORM) can localize high-emitter-density images. computational cost of this approach extremely high, which limits its practical application. Here, we propose an alternative...
Introduction Different opinions exist about the role of subchondral bone in osteoarthritis (OA), probably because has different effects on cartilage degeneration OA induced by pathologies. Animal studies to illustrate were mostly based post-traumatic (PT-OA). Postmenopausal women experience a much higher occurrence than similar-aged men. The physiological changes and pathogenesis osteochondral unit ovariectomy-induced (OVX-OA) might be distinct from other types OA. Methods alterations...
Multifocal structured illumination microscopy (MSIM) is the parallelized version of image scanning (ISM), which uses multiple diffraction limited spots, instead a single spot, to increase imaging speed. By adding pinhole, contraction and deconvolution, twofold resolution enhancement could be achieved in theory. However, this improvement difficult attained practice. In work, without any modification experimental setup, we propose use measurement vector (MMV) model sparse Bayesian learning...
This is a multicenter prospective cohort study to analyze the correlation of traditional Chinese medicine (TCM) syndrome evolvement and cardiovascular events in patients with stable coronary heart disease (CHD). The impact on during 6-month 12-month follow-up was analyzed using complex networks approach. Results verification Chi-square test showed that occurrence positively correlated when it evolved from toxic Qi deficiency, blood stasis, or sustained syndrome, deficiency stasis deficiency....