A5044810623- Sexual function and dysfunction studies
- Inflammatory Myopathies and Dermatomyositis
- Ferroptosis and cancer prognosis
- Psoriasis: Treatment and Pathogenesis
- IgG4-Related and Inflammatory Diseases
- Neuroendocrine Tumor Research Advances
- Lung Cancer Treatments and Mutations
- Histone Deacetylase Inhibitors Research
- Nanowire Synthesis and Applications
- Prostate Cancer Treatment and Research
- Reproductive System and Pregnancy
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Ovarian function and disorders
- Hormonal and reproductive studies
- Spondyloarthritis Studies and Treatments
- Ubiquitin and proteasome pathways
- Lung Cancer Research Studies
- CAR-T cell therapy research
- Cancer Treatment and Pharmacology
- Pelvic floor disorders treatments
- Peptidase Inhibition and Analysis
- Neurogenetic and Muscular Disorders Research
- Pregnancy and Medication Impact
- Autophagy in Disease and Therapy
Henan Agricultural University
2024-2025
Guizhou University
2024-2025
The First People’s Hospital of Lianyungang
2021-2025
Xuzhou Medical College
2023-2025
Chengdu University of Traditional Chinese Medicine
2017-2025
Nanjing Medical University
2024-2025
Zhejiang University
2025
Tianjin Medical University General Hospital
2023-2024
Shanghai Jiao Tong University
2020-2024
Shanghai Children's Medical Center
2020-2024
Prevention of metastatic and local-regional recurrence cancer after surgery remains difficult. Targeting postsurgical premetastatic niche microresiduals presents an excellent prospective opportunity but is often challenged by poor therapeutic delivery into minimal residual tumors. Here, enzymatically transformable polymer-based nanotherapeutic approach presented that exploits matrix metalloproteinase (MMP) overactivation in tumor-associated tissues to guide the codelivery colchicine...
Aspergillus cristatus is a crucial edible fungus used in tea fermentation. In the industrial fermentation process, experiences low to high osmotic pressure environment. To explore law of material metabolism changes during changes, NaCl was here construct different environments. Liquid chromatography–mass spectrometry (LC–MS) combined with multivariate analysis performed analyze distribution and composition A. under salt concentrations. At same time, vitro antioxidant activity evaluated. The...
Abstract Primary membranous nephropathy (PMN) is one of the leading causes end‐stage renal disease, and most frequent cause massive proteinuria in nondiabetic adults, resulting fatal complications. However, underlying pathomechanisms PMN remain largely unclear. Here, single‐cell RNA sequencing employed to analyze kidney biopsies from eleven patients seven healthy subjects. Profiling 44 060 cells allowed us characterize cellular composition cell‐type‐specific gene expression kidney. The...
To explore the value of cytogenetic risk stratification combined with minimal residual disease (MRD) status in predicting therapeutic efficacy and prognosis for multiple myeloma (MM). From January 2017 to December 2023, 73 cases newly diagnosed MM were recruited. Cytogenetic risks stratified according results fluorescence situ hybridization (FISH); MRD clinical data analyzed. The progression-free survival (PFS) overall (OS), their influencing factors evaluated. During median follow-up period...
// Jinjing Wang 1, * , Wenhao Guo Hang Zhou 2, Na Luo 3 Chunlai Nie 1 Xinyu Zhao Zhu Yuan Liu Yuquan Wei Department of Abdominal Oncology, State Key Laboratory Biotherapy and Cancer Center, West China Hospital, Sichuan University Collaborative Innovation Center for Biotherapy, Chengdu 610041, P. R. 2 Chemotherapy, Chengdu, Nankai School Medicine/Collaborative Tianjin 300071, These authors have contributed equally to this work Correspondence to: Nie, e-mail: niecl1022@hotmail.com Liu,...
Background: Optic perineuritis (OPN) is a special optic neuropathy that has distinct etiology from neuromyelitis optica spectrum disorders (NMOSDs) or multiple sclerosis (MS)-related neuritis (ON). The mechanisms of how this inflammation developed and invaded the nerve sheath remain unknown. This study aimed to analyze different clinical characteristics OPN in Chinese patient population. Methods: Neuro-ophthalmological examination, orbit magnetic resonance imaging (MRI) series blood samples...
B-cell acute lymphocytic leukemia (B-ALL), a common blood cancer in children, leads to high mortality. Cyclin-dependent kinase 9 inhibitor (CDK9i) effectively attenuates myeloid and chronic lymphoblastic by inducing apoptosis inhibiting cell proliferation. However, the effect of CDK9i on B-ALL cells underlying mechanisms remain unclear. In this study, we showed that induced vitro activating apoptotic pathways. addition, restrained glycolytic metabolism cells, CDK9i-induced was enhanced...
Abstract Background There is growing evidence of a possible correlation between depression and overactive bladder (OAB). However, few studies have classified according to its severity. Whether there an association different levels OAB symptoms remains unclear. Methods Participants with complete information about depression, OAB, covariates in the National Health Nutrition Examination Survey (NHANES) 2005–2018 were included this study. Depression assessed by Patient Questionnaire‐9. evaluated...
pH is an important environmental factor affecting the survival of fungi, and Aspergillus cristatus, which can grow reproduce over a wide range pH, suitable for studying their adaptation mechanism to stress. In this study, A. cristatus was cultured on plates different initial (pH 3.8-8.0), with results revealing distinct morphologies at 3.0-5.0, 6.0-7.0 8.0. Liquid chromatography-mass spectrometry (LC-MS) multivariate analysis subsequently were used analyze changes substance metabolism pH....
The crosstalk between apoptosis and autophagy contributes to tumorigenesis cancer therapy. process by which BetA (betulinic acid), a naturally occurring triterpenoid, regulates as therapy is unclear. In this study, we show for the first time that protein phosphatase 2A (PP2A) acts switch regulate autophagic cell death mediated BetA. Under normal conditions, caspase-3 activated mitochondrial pathway upon treatment. Activated cleaves A subunit of PP2A (PP2A/A), resulting in association Akt....
Abstract Background The relationship between erectile dysfunction (ED) and physical activity has been established in several previous studies, but there is little information on the specific forms of that affect ED. Aim objective this study was to evaluate 4 exercise categories 2 intensities with ED US men. Methods We used data sets from National Health Nutrition Examination Survey, 2001-2004. odds ratios (ORs) multivariate logistic regression models investigate also conducted subgroup...
Background The risk of visceral obesity on erectile function has recently attracted much attention. adiposity index (VAI) is a brief and reliable indicator measurement. Nevertheless, the association between VAI dysfunction (ED) not completely clarified. Methods Data from NHANES 2001–2004 were enrolled in this study. Erectile was assessed by database-self-administered questionnaire. calculated with body mass (BMI), waist circumference (WC), triglyceride (TG), high-density lipoprotein (HDL)...
Abstract Chimeric antigen receptor (CAR)‐positive cell therapy, specifically with anti‐CD19 CAR‐T (CAR19‐T) cells, achieves a high complete response during tumor treatment for hematological malignancies. Large‐scale production and application of therapy can be achieved by developing efficient low‐cost enrichment methods expansion monitoring in vivo, overcoming escape. Here, novel CAR‐specific binding aptamers (CAR‐ap) to traceless sort CAR‐positive cells obtain positive rate CAR19‐T is...
B-cell acute lymphocytic leukemia (B-ALL) is a malignant blood cancer that develops in children and adults leads to high mortality. THZ1, covalent cyclin-dependent kinase 7 (CDK7) inhibitor, shows anti-tumor effects various cancers by inhibiting cell proliferation inducing apoptosis. However, whether THZ1 has an inhibitory effect on B-ALL cells the underlying mechanism remains obscure. In this study, we showed arrested cycle of vitro low concentration, while apoptosis concentration...
Background: Kidney-tonifying herbs (KTHs) are widely used to treat unexplained recurrent spontaneous abortion (URSA) based on the theory of traditional Chinese medicine (TCM). However, there is still a lack systematic evaluation and mechanistic explanation for these treatments. Objective: The purpose this study was assess clinical efficacy, investigate potential mechanisms, KTH TCM treatment URSA. Methods: A literature search conducted within PubMed, Embase, China Biomedical Literature...