A5033823611- Mesenchymal stem cell research
- Advanced biosensing and bioanalysis techniques
- Tryptophan and brain disorders
- RNA Interference and Gene Delivery
- Diet and metabolism studies
- Immunotherapy and Immune Responses
- Signaling Pathways in Disease
- Virus-based gene therapy research
- Nerve injury and regeneration
- Pluripotent Stem Cells Research
- Nuclear Structure and Function
- Telomeres, Telomerase, and Senescence
- Nuclear Receptors and Signaling
- Tissue Engineering and Regenerative Medicine
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cancer Cells and Metastasis
- Stress Responses and Cortisol
- Cellular Mechanics and Interactions
- Diabetes Management and Research
- Bone Tissue Engineering Materials
Peking University Shenzhen Hospital
2020-2023
Beijing Institute of Education
2021
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2021
Academy of Military Medical Sciences
2019-2020
Chinese PLA General Hospital
2020
Abstract Background Astrocytes are crucial regulators in the central nervous system. Abnormal activation of astrocytes contributes to some behavior deficits. However, mechanisms underlying effects remain unclear. Here, we studied A1 and their contribution murine Methods were induced by treatment with lipopolysaccharide (LPS) vitro. The functional phenotype was determined quantitative RT-PCR, ELISA, immunohistochemistry. To assess role vivo, mice injected intraperitoneally LPS. Then,...
Accumulating evidence indicates that microRNAs (miRNAs) play crucial roles in osteogenic differentiation. However, the associated mechanisms remain elusive. This paper is aimed at exploring role of miR-129-5p regulating bone marrow mesenchymal stem cell (BMSC) differentiation and regeneration vivo vitro. BMSCs were transduced by mimic, inhibitor, negative control lentivirus. The ability BMSC to osteoblast was tested alkaline phosphatase (ALP) alizarin red staining (ARS). expression genes...
Major depressive disorder (MDD) is a leading cause of disability worldwide. A comprehensive understanding the molecular mechanisms this critical for therapy MDD. In study, it observed that deubiquitinase Mysm1 induced in brain tissues from patients with major depression and mice behaviors. The genetic silencing astrocytic an antidepressant-like effect alleviated osteoporosis mice. Furthermore, found knockdown led to increased ATP production activation p53 AMP-activated protein kinase (AMPK)....
Aging is a predominant risk factor for many chronic conditions. Stem cell dysfunction plays pivotal role in the aging process. Prelamin A, an abnormal processed form of nuclear lamina protein lamin has been reported to trigger premature senescence. However, mechanism driving stem still unclear. In this study, we found that while passaging subchondral bone mesenchymal cells (SCB-MSCs) vitro, prelamin A accumulation occurred concomitantly with increase senescence-associated β-galactosidase...
Adipose-derived stem cells (ASCs) have become one of the most promising cell populations for cell-based therapies in regenerative medicine and autoimmune disorders owing to their multilineage differentiation immunomodulatory capacities, respectively. One advantage ASC-based therapy lies immunosuppressive potential. However, how get ASCs provide consistent immunosuppression remains unclear. In current study, we found that miR-129-5p was induced treated with inflammatory factors. knockdown...
The effective use of MSCs for the treatment some B cell-mediated immune diseases is quite limited. main reason that immunomodulatory effects mesenchymal stem cells (MSCs) on are unclear, and their underlying mechanisms have not been fully explored.By co-culturing with without (MSC/CTLsh) or suppressor cytokine signaling 1 (SOCS1) knockdown (MSC/SOCS1sh), we found inhibited cell proliferation, activation terminal differentiation. Remarkably, highest inhibition proliferation was observed in...
Self-assembled amino acid derivatives could form well-defined nanostructures which have great application value for drug delivery systems. In particular, D-amino possess tremendous advantages including anti-degradation and good lysosome escape compared with L-amino derivatives. this work, 9-fluorenylmethyloxycarbonyl (Fmoc) neighboring D-arginine were replaced by dibenzocyclooctyne (DBCO) to extend the class of functional derivatives, further reacted various cross-linkers azide construct a...
The utilization of cytosolic protein delivery is a promising approach for treating various diseases by replacing dysfunctional proteins. Despite the development nanoparticle-based intracellular methods, complicated chemical synthesis vector, loading efficiency and endosomal escape proteins remain great challenge. Recently, 9-fluorenylmethyloxycarbonyl (Fmoc)-modified amino acid derivatives have been used to self-assemble into supramolecular nanomaterials drug delivery. However, instability...