A5052575702- Neuroinflammation and Neurodegeneration Mechanisms
- Prosthetics and Rehabilitation Robotics
- Nerve injury and regeneration
- Cancer, Hypoxia, and Metabolism
- Signaling Pathways in Disease
- MicroRNA in disease regulation
- Acute Myeloid Leukemia Research
- Spinal Cord Injury Research
- Immune cells in cancer
- Muscle activation and electromyography studies
- Inflammasome and immune disorders
- Tryptophan and brain disorders
- Diet and metabolism studies
- Whipple's Disease and Interleukins
- Advanced biosensing and bioanalysis techniques
- Neonatal and fetal brain pathology
- Inflammation biomarkers and pathways
- Tissue Engineering and Regenerative Medicine
- Stroke Rehabilitation and Recovery
- Adenosine and Purinergic Signaling
- Nuclear Receptors and Signaling
- Glioma Diagnosis and Treatment
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Galectins and Cancer Biology
Ningxia Medical University
2025
Chinese PLA General Hospital
2019-2024
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2024
Affiliated Hospital of Taishan Medical University
2024
Shandong First Medical University
2024
Beijing Institute of Education
2024
Chinese People's Liberation Army
2023
Abstract Blood vessels play a role in osteogenesis and osteoporosis; however, the of vascular metabolism these processes remains unclear. The present study finds that ovariectomized mice exhibit reduced blood vessel density bone expression endothelial glycolytic regulator pyruvate kinase M2 (PKM2). Endothelial cell (EC)‐specific deletion Pkm2 impairs worsens osteoporosis mice. This is attributed to impaired ability mesenchymal stem cells (BMSCs) differentiate into osteoblasts....
Targeted transfection of siRNA to preosteoclasts features the potential anti-osteoporosis, yet challenge arises from development satisfied delivery vehicles. Here, we design a rational core-shell nanoparticle (NP) composed cationic and responsive core for controlled load release small interfering RNA (siRNA) compatible polyethylene glycol shell modified with alendronate enhanced circulation bone-targeted siRNA. The designed NPs perform well on an active (siDcstamp) that interferes Dcstamp...
Stair climbing remains one of the toughest tasks elderly in activities daily livings (ADLs). However, most existing stair assistance devices are large and heavy, such as automatic wheelchair, rigid exoskeleton so on. They all lack applicability life. Based on this starting point, paper, a soft knee suit (Hitexosuit) has been developed to assist people climbing. It is lightweight wearable for human lower extremity stairs. This paper finds out certain phase motion that requires muscle strength...
<title>Abstract</title> Microglia are specialized resident immune cells of the central nervous system parenchyma that mediate reactions such as inflammatory response to spinal cord injury (SCI) and play significant roles in exacerbating or alleviating disease progression. Previous studies have suggested ferroptosis, a newly discovered form regulated necrotic cell death, plays crucial role neuronal dysfunction loss following SCI; however, microglial ferroptosis SCI underlying mechanisms...
In mammalian species, neural tissues cannot regenerate following severe spinal cord injury (SCI), for which stem cell transplantation is a promising treatment. Neural cells (NSCs) have the potential to repair SCI; however, in unfavourable microenvironments, transplanted NSCs mainly differentiate into astrocytes rather than neurons. contrast, bone mesenchymal (BMSCs) promote differentiation of neurons and regulate inflammatory responses. Owing their easily controllable mechanical properties...
Excessive immune activation induces tissue damage during infection. Compared to external strategies reconstruct homeostasis, host balancing ways remain largely unclear. Here we found a neuroimmune way that prevents infection-induced damage. By FACS and histopathology analysis of brain Streptococcus pneumonia meningitis infection model behavioral testing. Western blot, co-immunoprecipitation, ubiquitination analyze the Fluoxetine initiate 5-HT7R-STUB1-CCR5 K48-linked degradation. Fluoxetine,...
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Abstract Blood vessels play a role in osteogenesis and osteoporosis; however, the of vascular metabolism is unclear. The present study found that ovariectomized mice exhibit reductions bone blood vessel density expression endothelial glycolytic regulator pyruvate kinase M2 (PKM2). Additional data showed cell (EC)-specific deletion Pkm2 impair worsen osteoporosis mice. This was attributed to impaired differentiation ability toward osteoblast mesenchymal stem cells (BMSCs). Mechanistically,...
Lower-limb exoskeletons have attracted considerable interest because they can provide impaired individuals with the ability to walk upright. Trajectory generation of walking gait is a crucial issue for lower-limb that has not yet been satisfactorily solved. The purpose this article study stable method considering subjective intention. Inspired by motion synergy between crutches and lower limbs, flat-ground was proposed exoskeleton. in sagittal plane crutch-pitch-angle step length validated...