A5101880745- Acupuncture Treatment Research Studies
- Mathematical functions and polynomials
- Fractional Differential Equations Solutions
- Iterative Methods for Nonlinear Equations
- Healthcare and Venom Research
- Electromagnetic Scattering and Analysis
- Rheumatoid Arthritis Research and Therapies
- Glioma Diagnosis and Treatment
- Retinal and Optic Conditions
- Traditional Chinese Medicine Studies
- Dysphagia Assessment and Management
- Retinal Diseases and Treatments
- SARS-CoV-2 and COVID-19 Research
- Blood transfusion and management
- Sleep and Wakefulness Research
- Pain Management and Placebo Effect
- Autoimmune and Inflammatory Disorders Research
- Sleep and related disorders
- Angiogenesis and VEGF in Cancer
- Complementary and Alternative Medicine Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Chemokine receptors and signaling
- Mathematical Approximation and Integration
- Facial Nerve Paralysis Treatment and Research
Guangzhou University of Chinese Medicine
2007-2025
Zhengzhou University of Light Industry
2015-2025
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2022-2025
Beijing Institute of Education
2022-2025
Johns Hopkins Medicine
2011-2024
Johns Hopkins University
2011-2024
Children's National
2019-2024
Anyang Hospital of Traditional Chinese Medicine
2023
Guangdong Provincial Hospital of Traditional Chinese Medicine
2011-2023
GCI Science & Technology (China)
2022
Abstract Objective To evaluate the efficacy and safety of golimumab in patients with ankylosing spondylitis (AS) GO‐RAISE study. Methods Patients active AS, a Bath AS Disease Activity Index (BASDAI) score ≥4, back pain ≥4 were randomly assigned 1.8:1.8:1 ratio to receive subcutaneous injections (50 mg or 100 mg) placebo every 4 weeks. The primary end point was proportion at least 20% improvement ASsessment (ASAS20) criteria week 14. Results At randomization, 138, 140, 78 50‐mg, 100‐mg,...
Human beclin 1 is the first identified mammalian gene to induce autophagy. It commonly expressed at reduced levels in breast tumors; however, it overexpressed hepatitis B virus (HBV)-infected cancerous liver tissues. To expose possible mechanism and biological significance of this up-regulation 1, we investigated regulation expression by HBV x protein (HBx) hepatic or hepatoma cell lines. Here, showed that enforced HBx transfection technology results endogenous messenger RNA (mRNA) Beclin...
This report aims to determine the safety, pharmacokinetics (PK) and efficacy of subcutaneous golimumab in active polyarticular-course juvenile idiopathic arthritis (polyJIA).In this three-part randomised double-blinded placebo-controlled withdrawal trial, all patients received open-label (30 mg/m2 body surface area; maximum: 50 mg/dose) every 4 weeks together with weekly methotrexate during Part 1 (weeks 0-16). Patients at least 30% improvement per American College Rheumatology Criteria for...
Significance Delayed revascularization of ischemic neural tissue is a major impediment to preservation function in central nervous system (CNS) diseases including stroke and retinopathies. The key mechanisms governing vascular recovery CNS, regulatory molecules transition from injury repair, are largely unknown. We report here on NF-E2-related factor 2 (Nrf2), stress-response transcription known for its cell-intrinsic cytoprotective function, novel capacity coordinating repair remodeling,...
Retinal ischemia results in neuronal degeneration and contributes to the pathogenesis of multiple blinding diseases. Recently, fumaric acid ester dimethyl fumarate (DMF) has been FDA-approved for treatment sclerosis, based on its neuroprotective anti-inflammatory effects. Its potential role as a agent retinal diseases received little attention. In addition, DMF's mode action remains elusive, although studies have suggested nuclear factor erythroid 2-related 2 (Nrf2) activation an important...
Purpose: To investigate the expression of angiotensin-converting enzyme 2 (ACE2), receptor for SARS-CoV-2 in human retina. Methods: Human post-mortem eyes from 13 non-diabetic control cases and 11 diabetic retinopathy were analyzed ACE2. compare vascular ACE2 between different organs that involve diabetes, was investigated renal specimens nondiabetic nephropathy patients. Expression TMPRSS2, a cell-surface protease facilitates entry, also retinas. Primary retinal endothelial cells (HRECs)...
Abstract Ischemic retinopathies including diabetic retinopathy are major causes of vision loss. Inner blood-retinal barrier (BRB) breakdown with retinal vascular hyperpermeability results in macular edema. Although dysfunction the neurovascular unit neurons, glia, and cells is now understood to underlie this process, there a need for fuller elucidation underlying events BRB ischemic disease, systematic analysis myeloid exploration cellular cross-talk. We used an approach microglia depletion...
A subset of group 3 medulloblastoma frequently harbors amplification or overexpression MYC lacking additional focal aberrations, yet it remains unclear whether alone can induce tumorigenesis and which cells give rise to these tumors. Here, we showed that astrocyte progenitors in the early postnatal cerebellum were susceptible transformation by MYC. The resulting tumors specifically resembled human based on histology gene-expression profiling. Gene-expression analysis MYC-driven revealed...
Abstract Purpose Conjunctival signs and symptoms are observed in a subset of patients with COVID-19, SARS-CoV-2 has been detected tears, raising concerns regarding the eye both as portal entry carrier virus. The purpose this study was to determine whether ocular surface cells possess key factors required for cellular susceptibility entry/infection. Methods We analyzed human post-mortem eyes well surgical specimens expression ACE2 (the receptor SARS-CoV-2) TMPRSS2, cell surface-associated...
Abstract Cervical spondylosis (CS)-related neck pain is difficult to treat because of its degenerative nature. The aim this 9-center, single-blinded, randomized controlled trial was evaluate the efficacy optimized acupuncture for CS-related pain. Participants who met inclusion criteria were optimized, shallow, and sham groups (1:1:1). primary outcome change from baseline in Northwick Park Neck Pain Questionnaire score at week 4. followed up until 16. Of 896 participants, 857 received ≥1...
Major depressive disorder (MDD) is a leading cause of disability worldwide. A comprehensive understanding the molecular mechanisms this critical for therapy MDD. In study, it observed that deubiquitinase Mysm1 induced in brain tissues from patients with major depression and mice behaviors. The genetic silencing astrocytic an antidepressant-like effect alleviated osteoporosis mice. Furthermore, found knockdown led to increased ATP production activation p53 AMP-activated protein kinase (AMPK)....
Objective. Up to 62% of perimenopausal women have depression symptoms. However, there is no efficacy treatment. The aim this study compare the clinical and safety EA therapy escitalopram on perimenopause with mild-moderate depressive symptom. Method. A multicenter, randomized, positive-controlled trial was conducted at 6 hospitals in China. 242 symptom were recruited randomly assigned receive 36 sessions treatment or primary outcome measure 17-item Hamilton Depression Rating Scale (HAMD-17)....
Ischemic retinopathies including diabetic retinopathy are major causes of blindness. Although neurons and Müller glia recognized as important regulators reparative pathologic angiogenesis, the role mononuclear phagocytes (MPs) — particularly microglia, resident retinal immune cells is unclear. Here, we found MP activation in human retinopathy, especially neovessels from neovascular membranes proliferative TNF-α expression. There was similar mouse oxygen-induced (OIR) model ischemia-induced...
Abstract Metal corrosion has hindered the advancement of new technologies. The surfactant as one kind inhibitor can effectively restrain metal in corrosive medium. In this research, two cationic Gemini surfactants, 3,3′‐(ethane‐1,2‐diyl)bis(1‐octyl‐1 H ‐imidazol‐3‐ium) dibromide ([C 8 im‐2‐C im]Br 2 ) and 3,3′‐(butane‐1,4‐diyl)bis(1‐octyl‐1 im‐4‐C ), have been prepared for inhibition carbon steels 1.0 mol/L HCl solution. weight loss measurement demonstrates that inhibitors both achieve high...
This study aims to explore the central mechanisms of shallow acupuncture for chronic neck pain (CNP) using functional magnetic resonance imaging (fMRI) and diffusion tensor (DTI), an innovative approach not commonly applied in research. multi-center randomized controlled trial will recruit 252 CNP patients from three centers (84 per center). Participants be randomly assigned groups: acupuncture, drug control (celecoxib capsules), or waiting list group, with 84 group. The primary outcomes...
Background Stroke remains a leading cause of long-term disability globally, often complicated by cardiovascular comorbidities such as hypertension, atrial fibrillation, and coronary artery disease. These not only increase the risk recurrent strokes but also complicate recovery, making effective rehabilitation strategies crucial. Acupuncture, traditional Chinese medicine practice, has gained attention potential complementary therapy for stroke rehabilitation. This protocol outlines pooled...
Abstract Despite growing treatments for traumatic brain injury, there is still no ideal strategy efficiently mitigating these processes. Ultrashort wave therapy, a type of physical factor has been widely used in various clinical treatments. However, its effects on injury and the underlying mechanisms are not well understood. In this study, we demonstrate that ultrashort treatment can significantly promote repair alleviate emotional cognitive disorders. Our data showed reduced levels...