A5074551476- Lung Cancer Treatments and Mutations
- Tuberculosis Research and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- Epilepsy research and treatment
- Dermatology and Skin Diseases
- Inflammatory Bowel Disease
- Radiomics and Machine Learning in Medical Imaging
- Glycogen Storage Diseases and Myoclonus
- Pharmacological Effects and Toxicity Studies
- Asthma and respiratory diseases
- HER2/EGFR in Cancer Research
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Psoriasis: Treatment and Pathogenesis
- Monoclonal and Polyclonal Antibodies Research
- Microscopic Colitis
- Lysosomal Storage Disorders Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hepatitis C virus research
- Infectious Encephalopathies and Encephalitis
- Hereditary Neurological Disorders
- Bacterial Infections and Vaccines
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Kyoto University
2015-2025
Osaka University
1981-2025
University of Rochester Medical Center
2023-2024
Kanazawa University
1994-2024
Japanese Red Cross Society Wakayama Medical Center
2024
Toyota Motor North America (United States)
2023
University of Rochester
2023
Kindai University
2023
Chikamori Hospital
2019-2022
Kobe Pharmaceutical University
2022
Clinical severity of alternating hemiplegia childhood (AHC) is extremely variable. To investigate genotype-phenotype correlations in AHC, we analyzed the clinical information and ATP1A3 mutations patients with AHC.Thirty-five Japanese who were clinically diagnosed AHC participated this study. using Sanger sequencing. Detailed was collected from family members clinicians responsible for their care.Gene analysis revealed 33 de novo heterozygous missense ATP1A3: Glu815Lys 12 cases (36%),...
Atopic dermatitis (AD) is an inflammatory disorder characterized by dominant type 2 inflammation leading to chronic pruritic skin lesions, allergic comorbidities, and Staphylococcus aureus colonization infections. S thought play a role in AD severity.
Post-intensive care syndrome (PICS) affects the quality of life (QOL) survivors critical illness. Although PICS persists for a long time, longitudinal changes in each component and their interrelationships over time both remain unclear. This multicenter prospective study investigated 2-year trajectory its components as well factors contributing to deterioration or recovery mechanically ventilated patients with coronavirus disease 2019 (COVID-19), also attempted identify possible...
We have demonstrated previously that a diet containing skimmed milk (SM) fermented by Lactobacillus gasseri SBT2055 (LGSP) reduces adipocyte size in Sprague–Dawley rats. Two experiments were conducted to extend these observations order elucidate the mechanism involved. In experiment 1, lean and obese Zucker rats fed SM or LGSP for 4 weeks. The diet, compared with resulted lowering of mesenteric adipose tissue weight (23 %; P < 0·05), sizes (28 0·001) serum leptin concentration (36 0·05)...
Despite adequate scientific evidence of the potential benefits probiotics to human health or disease prevention, their contribution growth adipose tissue remains be established. Four-week-old male Sprague-Dawley rats were fed a diet containing skim milk (control diet) fermented by Lactobacillus gasseri SBT2055 (LGSP for 4 weeks. Their body weight gain, weight, adipocyte size distribution profile, blood and hepatic lipids, serum leptin, glucose adiponectin levels determined. There was...
Guine pigs basophils obtained from blood or bone marrow have been studied for their chemotactic responsiveness. Chemotactic factors include a substance (lymphokine) present in culture fluids antigen-stimulated lymphocytes, material generated zymosan-activated guinea pig serum, C5 cleavage factor, and bacterial factor. When compared with homologous neutrophils monocytes, respond most rapidly to stimulus. The lymphokine basophil factor is physicochemically similar the previously described...
Endothelial cells play a major role in the initiation and perpetuation of inflammatory process health disease, including their pivotal leukocyte recruitment. The pro-inflammatory transcription factors this has been well-described, NF-κB. However, much less is known regarding that an anti-inflammatory endothelial cells. Myocyte enhancer factor 2 C (MEF2C) to regulate angiogenesis Here, we report MEF2C plays critical function as inhibitor cell inflammation. Tumor necrosis (TNF)-α inhibited...
Pulmonary granulomas were induced in immunized BALB/c mice by the intratracheal injection of antigen-coated and plain agarose beads. Prominent lesions developed within 24 hr, reached peak intensity 3 days, gradually declined size thereafter. The hypersensitivity sensitized beads much larger than Minimal inflammation was produced unsensitized injected with or Aqueous extracts prepared from pulmonary granuloma contained high levels interleukin 1 (IL 1) migration inhibition factor (MIF)...
We examined HLA-A,B,C and DR locus antigens in 38 Japanese patients who had recovered from halothane hepatitis. The were divided into two subgroups, i.e. jaundice non-jaundice groups, because the clinical features quite different each. DR2 was positive 14 (58.3%) of 24 with jaundice, compared 281 (33.6%) 837 healthy controls (chi-square Yates' correction = 5.30, relative risk 2.77, P less than 0.025). Conversely, Bw44 increased (50.0%), 157 (12.7%) 1234 13.75, 6.86, 0.001). haplotype...
Pompe disease is caused by an inborn defect of lysosomal acid α-glucosidase (GAA) and characterized glycogen accumulation primarily in the skeletal muscle heart. Patients with severe type disease, infantile-onset (IOPD), show generalized weakness heart failure early infancy. They cannot survive over two years. Enzyme replacement therapy recombinant human GAA (rhGAA) improves survival rate, but its effect on insufficient compared to other organs. Moreover, patho-mechanism damage IOPD still...
Abstract Background Recently, rehabilitation robots are expected to improve the gait of cerebral palsy (CP) children. However, only few previous studies have reported kinematic and kinetic changes by using wearable exoskeleton robots. The aim this study was investigate change in parameters CP children training with robot-assisted training. Methods 10 spastic Gross Motor Function Classification Scale levels I-III completed a sham-controlled crossover randomized trial. Robot-assisted (RAGT)...
Thyroid antibodies in the sera of BUF rats are closely correlated with spontaneous thyroiditis; their detection may facilitate study this animal model organ-specific autoimmunity. In a group 115 retired breeders (females older than 1 year), 26% had mononuclear cell infiltration thyroid and high titers detectable by indirect immunofluorescence (IF) chromic chloride passive hemagglutination (CCH). contrast, low-titered were present 9% that normal thyroids. Sequential studies performed on 76...
The effects of glycyrrhizin, a component licorice (Glycyrrhiza glabra) roots, on the production interferon-gamma in human peripheral lymphocyte-macrophage cultures by concanavalin A (Con A) was examined. Interferon-gamma normal treated with 10 to 100 micrograms/ml glycyrrhizin at 37 degrees C for 12 hr or longer, and then Con A, enhanced four eight times compared control cell cultures. Lymphocyte-macrophage alone did not produce interferon. No significant difference adsorption [3H]Con...
Leukoencephalopathy with brain calcifications and cysts (LCC) is neuroradiologically characterized by leukoencephalopathy, intracranial calcification, cysts. Coats plus syndrome also the same neuroradiological findings together defects in retinal vascular development. Indeed, LCC were originally considered to be clinical entity termed cerebroretinal microangiopathy cysts, but evidence suggests that they are genetically distinct. Mutations CTS telomere maintenance complex component 1 (CTC1)...
Background/Aims 5-Aminosalicylic acid (ASA) causes intolerance reactions in some patients. This study was performed to examine the prognosis of patients with ulcerative colitis (UC) and 5-ASA intolerance, evaluate potential interaction between intestinal microbiota. Methods We a retrospective cohort UC who visited participating hospitals. The primary endpoint compare incidence hospitalization within 12 months group tolerance group. secondary risk adverse clinical outcomes after start...
Newly synthesized proteins destined for the secretory pathway are folded and assembled in endoplasmic reticulum (ER) then transported to Golgi apparatus via COPII vesicles, which normally 60-90 nm. vesicles must accordingly be enlarged accommodate larger than 90 nm, such as long-chain collagen. Key molecules involved this enlargement Tango1 Tango1-like (Tali), transmembrane ER encoded by MIA3 MIA2 genes, respectively. Interestingly, two splicing variants expressed from each of these genes:...
The association between prolonged febrile seizure and long‐term neurological sequelae in otherwise healthy children remains unclear. We conducted a retrospective cohort study using Japanese nationwide medical database. In the of 38,465 with seizures, 610 31,157 were classified into non‐prolonged groups, respectively. Within median 2.70 years follow‐up, risk subsequent epilepsy was significantly higher group (hazard ratio, 3.99; 95% confidence interval, 2.40–6.64). neurodevelopmental...