A5081083158- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Toxin Mechanisms and Immunotoxins
- Immune Response and Inflammation
- Clostridium difficile and Clostridium perfringens research
- Infective Endocarditis Diagnosis and Management
- Dermatology and Skin Diseases
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Kawasaki Disease and Coronary Complications
- Bacillus and Francisella bacterial research
- Bacterial Genetics and Biotechnology
- Biochemical and Structural Characterization
- Antimicrobial Peptides and Activities
- Neonatal and Maternal Infections
- Bacteriophages and microbial interactions
- Reproductive tract infections research
- Microbial infections and disease research
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- Immunotherapy and Immune Responses
- Preterm Birth and Chorioamnionitis
University of Iowa
2016-2025
University of Iowa Health Care
2024
University of Minnesota Medical Center
2007-2021
University of Iowa Hospitals and Clinics
2021
Carver Bible College
2017
University of Minnesota
2004-2015
University of Idaho
1997-2011
Twin Cities Orthopedics
1982-2011
Sea Research Foundation
2011
University of Connecticut
2011
There is concern that group A streptococci, which have caused less serious infections in developed countries recent decades, may be acquiring greater virulence. We describe 20 patients from the Rocky Mountain region who had streptococcal 1986 to 1988 were remarkable for severity of local tissue destruction and life-threatening systemic toxicity. Among (median age, 36), necrotizing fasciitis with or without myositis was most common soft-tissue infection (55 percent). Nineteen (95 percent)...
Journal Article Identification and Characterization of an Exotoxin from Staphylococcus aureus Associated with Toxic-Shock Syndrome Get access Patrick M. Schlievert, Schlievert Department Microbiology Immunology, School Medicine, University California, Los Angeles, CaliforniaCenters for Disease Control, Atlanta, Georgia Please address requests reprints to Dr. at his present address: Microbiology, Minnesota Medical School, 1060 Mayo Memorial Building, Box 196, Minneapolis, 55455. Search other...
IN 1978, Todd et al.1 described a multisystem clinical syndrome (toxic shock syndrome) characterized by the sudden onset of fever, rash, vomiting and diarrhea, hypotension, conjunctival injection, strawberry tongue, followed desquamation during recovery. The has been associated with colonization or infection toxin-producing Staphylococcus aureus. A toxin molecular weight 22,049, toxic toxin-1, formerly termed staphylococcal enterotoxin F pyrogenic exotoxin C, identified as product...
We have previously identified a gene in Staphylococcus aureus, agr, whose activity is required for high-level post-exponential-phase expression of series secreted proteins. In this paper, we describe the cloning Escherichia coli by using an inserted transposon (Tn551) as probe. The cloned gene, consisting 241-codon open reading frame containing site insertion, was recloned to S. aureus vector, pSK265, and shown be functional aureus. Activity evaluated determinations alpha-hemolysin,...
Genome sequences are available for many bacterial strains, but there has been little progress in using these data to understand the molecular basis of pathogen emergence and differences strain virulence. Serotype M3 strains group A Streptococcus (GAS) a common cause severe invasive infections with unusually high rates morbidity mortality. To gain insight into this high-virulence phenotype, we sequenced genome MGAS315, an organism isolated from patient streptococcal toxic shock syndrome. The...
Genetic diversity and relationships among 108 isolates of the bacterium Streptococcus pyogenes recently recovered from patients in United States with toxic-shock-like syndrome or other invasive diseases were estimated by multilocus enzyme electrophoresis. Thirty-three electrophoretic types (ETs), representing distinctive clonal genotypes, identified, but nearly half disease episodes, including more than two-thirds cases syndrome, caused strains two related clones (ET 1 ET 2). These also...
Infections caused by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) are being increasingly observed in patients who lack traditional risk factors. We described 8 postpartum women developed skin and soft-tissue infections MRSA at a mean time of 23 days (range, 4-73 days) after delivery. included 4 cases mastitis (3 which progressed to breast abscess), postoperative wound infection, cellulitis, pustulosis. The outbreak strains were compared with the prototype CA-MRSA...
ABSTRACT Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is a growing public health concern that has been associated with pediatric fatalities. It hypothesized the evolution of CA-MRSA recent event due to acquisition mec DNA by previously methicillin-susceptible strains circulated in community. This study investigated genetic relatedness between CA-MRSA, hospital-associated MRSA (HA-MRSA), and nonmenstrual toxic shock syndrome (nmTSS) isolates. Thirty-one 32 isolates...
T lymphocyte infiltration is a prominent feature of the skin inflammation associated with infections by toxin (superantigen)-secreting Staphylococcus aureus or Streptococcus bacteria. The cutaneous lymphocyte-associated antigen (CLA) has been hypothesized to be homing receptor (HR) involved in selective migration memory/effector cells skin. Since expression this putative skin-selective HR known under strict microenvironmental control, we sought determine effect staphylococcal and...
ABSTRACT We have previously demonstrated that the presence of oxygen is necessary for production toxic shock syndrome toxin 1 (TSST-1) by Staphylococcus aureus in vitro. To investigate mechanism which might regulate production, we identified homologs S. Bacillus subtilis resDE genes. The two-component regulatory system encoded , ResD-ResE, has been implicated global regulation aerobic and anaerobic respiratory metabolism B. . designated srrAB (staphylococcal response). effects expression on...
Toxic shock syndrome-associated staphylococcal and streptococcal exotoxins were tested for an ability to induce the production of tumor necrosis factor (TNF). Staphylococcal enterotoxins B C1, along with pyrogenic exotoxin A, all induced TNF in a dose-dependent manner, peaking on average at 3 days but continuing over 6 tested. This time course exotoxin-induced contrasts 1-day peak-2-day duration observed endotoxin as stimulus may be significant development toxic syndrome.
Quorum sensing via the accessory gene regulator (agr) system has been assigned a central role in pathogenesis of staphylococci, particularly Staphylococcus aureus. While control virulence expression vitro by agr relatively straightforward to describe, regulation both quorum response itself and genes vivo is considerably more complex. The highly dependent upon environment which organism grown strongly influenced additional regulators that respond signals other than cell density. There...