A5069889904- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Urticaria and Related Conditions
- Psoriasis: Treatment and Pathogenesis
- Cutaneous lymphoproliferative disorders research
- Autoimmune Bullous Skin Diseases
- Acne and Rosacea Treatments and Effects
- Nail Diseases and Treatments
- Vasculitis and related conditions
- Dermatologic Treatments and Research
- Exercise and Physiological Responses
- Rheumatoid Arthritis Research and Therapies
- Transgenic Plants and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Skin Protection and Aging
- Nonmelanoma Skin Cancer Studies
- Autoimmune and Inflammatory Disorders
- Contact Dermatitis and Allergies
- Cancer and Skin Lesions
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Genital Health and Disease
- Spondyloarthritis Studies and Treatments
University of Pennsylvania
2016-2025
California University of Pennsylvania
2021-2024
Philadelphia University
2017-2020
Translational Therapeutics (United States)
2020
Penn Center for AIDS Research
2018
Center for Clinical Research (United States)
2016
University of Pennsylvania Health System
2016
University of Puerto Rico System
2010-2012
University of Puerto Rico, Medical Sciences Campus
2011
BackgroundThe patient burden and quality of life (QOL) impact atopic dermatitis (AD) in the United States population is not well established.ObjectiveTo elucidate AD US population.MethodsA cross-sectional, population-based study 602 adults was performed. Atopic determined using modified UK Diagnostic Criteria for AD. Its severity assessed self-reported global severity, Patient-Oriented Eczema Measure (POEM), Scoring (PO-SCORAD), PO-SCORAD-itch, sleep. Quality short-form (SF-)12 mental...
Population-based estimates on the prevalence of atopic dermatitis in adults vary widely. The objectives this study were to determine population United States, distribution disease severity, and its impact health-related quality life. Among 1,278 participating adults, (95% confidence interval) was 7.3% (5.9–8.8). Overall, 60.1% (56.1–64.1) participants classified as having mild, 28.9% (25.3–32.7) moderate, 11% severe (8.6–13.7) disease. Patients with those more had higher scores dermatology...
Skin cancer is the most common malignancy occurring after organ transplantation. Although previous research has reported an increased risk of skin in solid transplant recipients (OTRs), no study estimated posttransplant population-based incidence United States.To determine and evaluate factors for cancer, including squamous cell carcinoma (SCC), melanoma (MM), Merkel (MCC) a cohort US OTRs receiving primary 2003 or 2008.This multicenter retrospective examined 10 649 adult performed at 26...
The relationship between atopic dermatitis (AD), anxiety and depression in the U.S. adult population is not well established. To determine of AD its severity with symptoms diagnosis adults. A cross‐sectional, population‐based study 2893 adults was performed. determined using modified U.K. Diagnostic Criteria. Adults vs. those without had higher mean Hospital Anxiety Depression Scale (HADS‐A) (7·7 5·6) (HADS‐D) (6·0 4·3) scores prevalences abnormal (≥ 11) HADS‐A (28·6% 15·5%) HADS‐D (13·5%...
<h3>Importance</h3> The risk of cancer in patients with psoriasis remains a cause special concern due to the chronic inflammatory nature disease, use immune-suppressive treatments and UV therapies, increased prevalence comorbid, well-established factors for cancer, such as smoking obesity, all which may increase carcinogenesis. <h3>Objective</h3> To compare overall specific cancers interest, compared without psoriasis. <h3>Design, Setting, Participants</h3> Population-based cohort study ages...
Immune dysfunction underlies the pathogenesis of rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). Immunosuppressive therapy is standard care for these diseases. Both immune therapy-related immunosuppression can inhibit cancer-related surveillance in this population. Drug-induced a risk factor nonmelanoma skin cancer (NMSC), particularly squamous cell tumors. For patients with history NMSC, data are limited on effect drugs additional NMSCs.
BackgroundAtopic dermatitis (AD) has been associated with multiple comorbid extracutaneous and systemic disorders. The relation between AD severity disease comorbidities is complex not fully understood.ObjectiveTo determine the comorbidities.MethodsA cross-sectional US population-based study of 8,217 adults who were participants in a nationally representative internet health panel was performed using structured questionnaire. A diagnosis determined modified United Kingdom Working Party...
Background: Psoriasis is a chronic inflammatory disease associated with dyslipidemia, cardiovascular events, and mortality. We aimed to assess compare the effect of treatment moderate-to-severe psoriasis adalimumab or phototherapy on vascular inflammation biomarkers. Methods Results: Randomized, double-blind, trial adalimumab, phototherapy, placebo (1:1:1) for 12 weeks, crossover 52 weeks total. Outcomes included by 18 F-fluorodeoxyglucose positron emission tomography/computed tomography...
To determine the risk of venous thromboembolism (VTE) defined as combined endpoint deep thrombosis (DVT) and pulmonary embolism (PE) among patients with psoriatic arthritis (PsA), psoriasis rheumatoid (RA) compared population controls. A cohort study was conducted in a primary care medical record database UK data from 1994–2014 PsA, RA, or psoriasis. Cox proportional hazards models were used to calculate relative for DVT, PE, VTE. An interaction disease modifying anti-rheumatic drugs (DMARD)...
An increasing number of cutaneous adverse reactions resulting from use programmed cell death protein 1 (PD-1) inhibitors have been described, but with relatively little focus to date on the timing these reactions.To determine drug after initiation PD-1 inhibitor therapy.This retrospective observational study included patients referred an academic dermatology clinic by oncologist January 1, 2014, through February 28, 2018, at least skin biopsy specimen a reaction associated use. Participants...
Atopic dermatitis (AD) is an inflammatory disorder characterized by dominant type 2 inflammation leading to chronic pruritic skin lesions, allergic comorbidities, and Staphylococcus aureus colonization infections. S thought play a role in AD severity.
Abstract Background Atopic dermatitis (AD) is associated with immunological dysfunction, which may influence cancer development. Previous studies of AD and demonstrate inconsistent results few these examined children or severity treatment. Objectives To determine malignancy risk among adults AD. Methods We conducted a cohort study using electronic health records data from UK general practices in The Health Improvement Network between 1994 2015. Children (&lt; 18 years old) (≥ were...
Improving regulated medical waste (RMW) management is crucial for enhancing planetary health and cost savings. We sought to assess an educational intervention on clinical staff understanding behavior regarding RMW management. This two-month (2023-2024) controlled, prospective at the University of Pennsylvania Health System surveyed healthcare workers, including physicians, nurses, assistants, from four inpatient medicine floors two dermatology clinics. Half settings were controls. The...
Abstract Background The distribution of atopic dermatitis (AD) lesions and its impact on quality life (QOL) is not well established in the US adult population. Objective To elucidate AD QOL adults with AD. Methods A cross‐sectional, population‐based study 602 was performed. determined using modified UK Diagnostic Criteria, lesional assessed. assessed Dermatology Life Quality Index (DLQI). Latent class analysis (LCA) used to determine distinct phenotypes distribution. Multivariable logistic...
The impact of atopic dermatitis (AD) on health-related quality life and health utility in the US adult population is not well established.To determine utilities quality-adjusted life-years (QALYs) lost adults with AD versus without population.A cross-sectional, population-based study 3495 was performed. determined using modified UK diagnostic criteria for AD. severity assessed self-reported global severity, Patient-Oriented Eczema Measure, Scoring AD, itch sleep. Six-dimensional state short...
Cutaneous manifestations of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), including granulomatosis with polyangiitis (GPA), microscopic (MPA), and eosinophilic (EGPA), are poorly characterized. This report describes the dermatologic features AAV their association systemic vasculitis.A cross-sectional study identifying comparing cutaneous was performed using data from a large, international, collaborative effort in order to collect comprehensive clinical on patients...
Purpose Ruxolitinib cream was evaluated in patients with facial/neck atopic dermatitis (AD) a decentralized, double-blind, randomized clinical trial (NCT05127421).
Patient-Oriented Eczema Measure (POEM) is the preferred patient-reported outcome (PRO) for assessing symptoms of atopic dermatitis (AD). Dermatology Life Quality Index (DLQI) commonly used to assess burden skin disease. Previous severity strata were developed POEM and DLQI in clinical cohorts, which may be biased toward more severe Severity not previously examined population-based cohorts. Scoring AD (PO-SCORAD) another PRO symptoms; however, are established.We sought confirm DLQI, develop...