A5057317213- Psoriasis: Treatment and Pathogenesis
- Atherosclerosis and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
- Vitamin D Research Studies
- Vitamin C and Antioxidants Research
- Lipoproteins and Cardiovascular Health
- Health Systems, Economic Evaluations, Quality of Life
- Spondyloarthritis Studies and Treatments
- Cardiac Imaging and Diagnostics
- Stress Responses and Cortisol
- Rheumatoid Arthritis Research and Therapies
- Mechanical Circulatory Support Devices
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Health and Mental Health
- Cardiac Structural Anomalies and Repair
- Respiratory Support and Mechanisms
- Dermatology and Skin Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Cerebrovascular and Carotid Artery Diseases
- Heart Failure Treatment and Management
- Tryptophan and brain disorders
- Cardiac Valve Diseases and Treatments
- Liver Disease Diagnosis and Treatment
University of Pittsburgh
2024
PES University
2024
Creighton University
2024
Sinai Hospital
2024
National Heart Lung and Blood Institute
2015-2023
National Institutes of Health
2015-2023
Icahn School of Medicine at Mount Sinai
2019-2023
University of Washington Medical Center
2023
Command Hospital
2021-2023
Creative Commons
2023
Psoriasis is a chronic inflammatory skin disease associated with increased coronary plaque burden and cardiovascular events. Biologic therapy for psoriasis has been found to be favorably luminal plaque, but it unclear whether these associations are attributable direct anti-inflammatory effects on the arteries.To investigate association of biologic inflammation in patients using perivascular fat attenuation index (FAI), novel imaging biomarker that assesses by mapping spatial changes...
Objective— To understand whether directly measured psoriasis severity is associated with vascular inflammation assessed by 18 F-fluorodeoxyglucose positron emission tomography computed tomography. Approach— In-depth cardiovascular and metabolic phenotyping was performed in adult patients (n=60) controls (n=20). Psoriasis using area index. Vascular average aortic target-to-background ratio Results— Both the (28 men 32 women, mean age 47 years) (13 7 41 were young low risk. index scores...
BACKGROUND. Systemic lupus erythematosus (SLE) is associated with enhanced risk of atherosclerotic cardiovascular disease not explained by Framingham score (FRS). Immune dysregulation to a distinct subset proinflammatory neutrophils (low density granulocytes; LDGs) may play key roles in conferring CV risk. This study assessed if LDGs are vivo vascular dysfunction and inflammation coronary plaque.
Background: Psoriasis, a chronic inflammatory disease associated with an accelerated risk of myocardial infarction, provides ideal human model to study atherogenesis in vivo. We hypothesized that the increased cardiovascular observed psoriasis would be partially attributable elevated subclinical coronary artery burden composed noncalcified plaques high-risk features. However, inadequate efforts have been made directly measure this vulnerable population. As such, we sought compare total...
Background: Psoriasis is a chronic inflammatory disease associated with dyslipidemia, cardiovascular events, and mortality. We aimed to assess compare the effect of treatment moderate-to-severe psoriasis adalimumab or phototherapy on vascular inflammation biomarkers. Methods Results: Randomized, double-blind, trial adalimumab, phototherapy, placebo (1:1:1) for 12 weeks, crossover 52 weeks total. Outcomes included by 18 F-fluorodeoxyglucose positron emission tomography/computed tomography...
GlycA, an emerging inflammatory biomarker, predicted cardiovascular events in population-based studies. Psoriasis, disease associated with increased risk, provides a model to study biomarkers (CVD). Whether GlycA associates psoriasis and how it predicts subclinical CVD beyond high-sensitivity C-reactive protein is unknown.To investigate the relationships between CVD.Patients controls (n=412) participated 2-stage study. We measured by nuclear magnetic resonance spectroscopy. National...
Inflammation is critical in the development of atherosclerosis. Psoriasis a chronic inflammatory skin disease that associated with increased vascular inflammation by 18fluorodeoxyglucose positron emission tomography/computed tomography vivo and future cardiovascular events. It provides human model to understand effect treating target organ (eg, skin) on diseases.To investigate association between change severity at 1 year characterize impact anti-tumor necrosis factor therapy inflammation.In...
Abstract Chronic inflammation is a critical component of atherogenesis, however, reliable human translational models aimed at characterizing these mechanisms are lacking. Psoriasis, chronic inflammatory skin disease associated with increased susceptibility to atherosclerosis, provides clinical model that can be utilized investigate the links between and atherosclerosis development. We sought key biological processes in psoriasis vascular tissue identify components may promote conditions....
Cholesterol efflux capacity (CEC) was recently shown to predict future cardiovascular (CV) events. Psoriasis both increases CV risk and impairs CEC. However, whether having poor CEC is associated with coronary plaque burden currently unknown. We aimed assess the cross-sectional relationship between assessed by quantitative computed tomography angiography (CCTA) in a well-phenotyped psoriasis cohort. Total non-calcified (NCB) indices were 101 consecutive patients using software. quantified...
Psoriasis is associated with an increased risk of cardiovascular diseases. Subclinical atherosclerosis in patients psoriasis has not been compared other conditions and more rigorous disease screening, such as type 2 diabetes.To assess the burden asymptomatic coronary measured by artery calcium score moderate to severe diabetes healthy controls.Three single-center, cross-sectional studies were performed recruited from specialty outpatient clinics without (recruited November 1, 2013, through...
Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study atherogenesis. Because neutrophils are implicated in atherosclerosis development, this reports that the interaction among low-density granulocytes, subset of neutrophils, platelets noncalcified coronary plaque burden assessed by computed tomography angiography. early atherosclerotic can lead fatal myocardial infarction, granulocyte-platelet may play crucial target...
Inflammation is critical to atherosclerosis. Psoriasis, a chronic inflammatory disease associated with early cardiovascular events and increased aortic vascular inflammation (VI), provides model study the process of atherogenesis. Fludeoxyglucose F 18 positron emission tomography/computed tomography (18F-FDG PET/CT) helps quantify VI, coronary computed angiography artery (CAD) assessment through evaluation total plaque burden (TB) noncalcified (NCB), luminal stenosis, high-risk plaques...
Women comprise approximately one-third of the advanced heart failure population but may receive fewer therapies including left ventricular assist devices (LVADs). During early pulsatile-flow device era, women had higher post-LVAD mortality and increased complications. However, knowledge about these differences in continuous-flow era is limited. Therefore, we sought to explore temporal trends LVAD utilization by sex.Patients with implantation from 2004 2016 were identified using Nationwide...
Psoriasis is a systemic inflammatory skin disease associated with cardiovascular and lipid dysfunction. However, traditional parameters have limited prognostic value, whereas assessing oxidation-modified lipids in this driven condition may capture additional risk. Recently, study showed that psoriasis was increased lipid-rich coronary plaques; therefore, investigating potential relationships speed understanding of psoriasis.To understand whether associate phenotypes, cardiometabolic...
Objective To assess the effect of tumor necrosis factor inhibitors ( TNF i) on subclinical cardiovascular disease in patients with psoriatic disease. Methods We performed a 2‐stage study. In stage 1, carotid total plaque area was assessed psoriasis or arthritis (PsA) (n = 319) by ultrasound at baseline and after 2–3 years. The annual progression rate atherosclerosis outcome interest. 2, PsA receiving i 21) age‐ sex‐matched not any biologic agent 13) underwent 18 F‐fluorodeoxyglucose–positron...
Inflammation is critical to atherogenesis. Psoriasis a chronic inflammatory skin disease that accelerates atherosclerosis in humans and provides compelling model understand potential pathways linking these diseases. A murine capturing the vascular metabolic diseases psoriasis would accelerate our understanding provide platform test emerging therapies. We aimed characterize new of inflammation (Rac1V12) from cardiovascular standpoint identify novel atherosclerotic signaling modulated...
Psoriasis is a systemic chronic inflammatory condition associated with increased risk of cardiovascular disease. Data demonstrating that decreased skin inflammation reduces events in patients psoriasis may be generalizable to other states heightened risk.To determine whether tumour necrosis factor inhibitor (TNFi) therapy major adverse (MACE) psoriasis.In this retrospective cohort study using the KPSC health plan, had at least three ICD-9 codes for and no antecedent MACE codes. Propensity...