A5075827012- Psoriasis: Treatment and Pathogenesis
- Systemic Lupus Erythematosus Research
- Vitamin D Research Studies
- Spondyloarthritis Studies and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Motor Control and Adaptation
- Inflammasome and immune disorders
- Health Systems, Economic Evaluations, Quality of Life
- Lipoproteins and Cardiovascular Health
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hemoglobinopathies and Related Disorders
- S100 Proteins and Annexins
- Stress Responses and Cortisol
- Cardiovascular Disease and Adiposity
- Bone health and osteoporosis research
- Coccidia and coccidiosis research
- Multisensory perception and integration
- Antimicrobial Peptides and Activities
- Infrared Thermography in Medicine
- Liver Disease Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Biosimilars and Bioanalytical Methods
National Heart Lung and Blood Institute
2019-2023
National Institutes of Health
2019-2023
MedStar Washington Hospital Center
2020
University of St. Gallen
1998-2000
The use of biologic therapy has increased over the past decade well beyond primary autoimmune diseases. Indeed, a recent trial using an anti-IL-1beta antibody reduced second myocardial infarction (MI) in those who have had MI. Psoriasis is chronic inflammatory disease often treated with biologics when severe, associated risk MI, part driven by high-risk coronary plaque phenotypes computed tomography angiography (CCTA). We hypothesized that we would observe reduction inflammatory-driven...
Psoriasis is a chronic inflammatory skin disease associated with increased coronary plaque burden and cardiovascular events. Biologic therapy for psoriasis has been found to be favorably luminal plaque, but it unclear whether these associations are attributable direct anti-inflammatory effects on the arteries.To investigate association of biologic inflammation in patients using perivascular fat attenuation index (FAI), novel imaging biomarker that assesses by mapping spatial changes...
Background: Lipid-rich necrotic core (LRNC), a high-risk coronary plaque feature assessed by computed tomography angiography, is associated with increased risk of future cardiovascular events in patients subclinical, nonobstructive artery disease. Psoriasis chronic inflammatory condition that prevalence and events. This study characterized LRNC psoriasis how modulates response to biologic therapy. Methods: Consecutive naïve (n=209) underwent angiography at baseline 1-year assess changes...
Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study atherogenesis. Because neutrophils are implicated in atherosclerosis development, this reports that the interaction among low-density granulocytes, subset of neutrophils, platelets noncalcified coronary plaque burden assessed by computed tomography angiography. early atherosclerotic can lead fatal myocardial infarction, granulocyte-platelet may play crucial target...
BACKGROUNDPsoriasis is a chronic inflammatory skin disease associated with increased obesity, noncalcified coronary artery burden (NCB), and incident myocardial infarction. Here, we sought to assess the relationship among inflammation, visceral adipose tissue (VAT), NCB. Furthermore, evaluated whether improvement in VAT would be reduction NCB over time psoriasis.METHODSConsecutive psoriasis patients underwent CT angiography quantify abdominal calculate at baseline (n = 237), 1 year 176), 4...
Psoriasis, a chronic inflammatory skin disease associated with accelerated noncalcified coronary burden (NCB) by computed tomography angiography (CCTA), accelerates lipoprotein oxidation in the form of oxidized modified lipoproteins. A transmembrane scavenger receptor for these lipoproteins is lectinlike low-density receptor-1 (LOX-1), which has been reported to be artery disease. It unknown whether this psoriasis.To assess association between soluble LOX-1 (sLOX-1) and NCB psoriasis over...
Inflammation plays an important role in the development of cardiovascular disease (CVD). Patients with chronic inflammation diseases have high levels and early fatal myocardial infarction due to early, unstable coronary plaques. Cholesterol crystals (CC) play a key atherogenesis. However, underlying mechanisms endothelial cell (EC)-derived CC formation are not well understood inflammation.We utilized combination mouse psoriasis model (K14-Rac1V12 model) human patients study effect...
Background Myocardial infarction and premature death have been observed in patients with psoriasis. Although inflammation‐driven accelerated atherosclerosis has proposed as a mechanism, the relationship between subclinical noncalcified coronary burden (NCB), functional flow impairment, myocardial injury is unclear. Methods Results In an ongoing longitudinal cohort study, 202 consecutive psoriasis (168 at 1 year) underwent computed tomography angiography to identify plaque, quantify NCB,...
Somatosensory discrimination of cuboid objects was studied in a group healthy volunteers and patients with Parkinson's disease using regional cerebral blood flow (rCBF) measurements obtained positron emission tomography (PET) 15O labeled water [H2 15O]. A 6-[18F]-fluoro-L-dopa (FDOPA) PET scan demonstrated that the may be grouped into those normal abnormally lowA FDOPA uptake caudate nucleus. The categorical comparisons revealed task-induced rCBF increases were deficient bilateral motor...
Psoriasis (PSO) is a chronic and systemic inflammatory autoimmune disease associated with atherosclerosis myocardial infarction. Given that both inflammation immune-driven, we sought to expand on known immune biomarkers in psoriasis cohort. Here focus oxidized mitochondrial DNA (ox-mtDNA), product of cells undergoing pyroptosis, including keratinocytes, which was quantified PSO patients non-PSO individuals by ELISA. had significantly higher ox-mtDNA levels compared healthy subjects...
The aim of our study was to establish colour Doppler-assisted duplex imaging (CDDI)-criteria predict an angiographic internal carotid artery (ICA) stenosis at least 70%, according the North American Symptomatic Carotid Endarterectomy Trial (NASCET) and European Surgery Trialists (ECST) methods measurement. In following, we describe findings in 79 patients who were screened for endarterectomy by CDDI further evaluated digital subtraction angiography (DSA). 158 arteries, 107 stenoses > 30%...
Increased left ventricular (LV) mass is an important precursor to heart failure. Inflammation plays role in increasing LV mass. However, the contribution of subclinical coronary artery disease (CAD) inflammation-LV relationship unknown. In subjects with psoriasis, a chronic inflammatory skin disease, we evaluated if systemic inflammation assessed by plasma glycoprotein A (GlycA) associated measured on CT angiography (CCTA). Additionally, analyzed whether this was mediated early CAD as...
Near infrared spectroscopy was used to quantify tissue hemodynamics in patients with sickle cell disease and compared ethnic-matched healthy controls. There are significant differences cerebral muscle between these cohorts.
Abstract Introduction Fibrofatty plaque burden (FFB) is a high-risk, vulnerable feature comprised of an atheromatous core and fibrous cap with increased risk coronary artery disease (CAD) [1]. Psoriasis (PSO) chronic inflammatory linked atherosclerotic premature cardiovascular disease, driven in part by rupture [2,3]. Machine learning (ML) previously showed the prognostic value FFB predicting 5-year cardiac-related mortality patients CAD [4]. Whether ML can predict psoriasis understudied....
Introduction: Psoriasis is a common, inflammatory skin disease associated with systemic inflammation and heightened risk of cardiovascular diseases (CVD). Population studies have shown that psoriasis metabolic syndrome (MetSyn) its individual components. However, the impact MetSyn on early atherosclerosis in chronic assessed as non-calcified coronary plaque burden (NCB) by computed CT angiography (CCTA) not known. Hypothesis: We hypothesized those would increased NCB compared to non-MetSyn...