A5026205385- Immune Response and Inflammation
- Neonatal Respiratory Health Research
- S100 Proteins and Annexins
- Congenital Diaphragmatic Hernia Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Psoriasis: Treatment and Pathogenesis
- Hematological disorders and diagnostics
- Sepsis Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Systemic Lupus Erythematosus Research
- Fatty Acid Research and Health
- Inflammasome and immune disorders
- Biochemical and Structural Characterization
- Wnt/β-catenin signaling in development and cancer
- Protease and Inhibitor Mechanisms
- Neuroscience of respiration and sleep
- Antimicrobial Peptides and Activities
- Ethics and Legal Issues in Pediatric Healthcare
Yale University
2025
National Heart Lung and Blood Institute
2021-2023
National Institutes of Health
2021-2023
Mattel Children's Hospital
2020-2021
Persistent skin inflammation and impaired resolution are the main contributors to psoriasis associated cardiometabolic complications. Omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA), docosahexaenoic (DHA), known exert beneficial effects on inflammatory response lipid function. However, a specific role of omega-3 PUFAs in accompanied pathologies still matter debate. Here, we carried out direct comparison between EPA DHA 12 weeks diet intervention treatment...
Recently, some methyltransferase-like (METTL) proteins have been found to play crucial roles in the development of acute myeloid leukemia (AML) through mediating RNA modifications, such as METTL3/14/16 mediated N6-methyladenosine (m6A) and METTL1 N7-methylguanosine (m7G). However, other METTL AML progression remain unknown. Here, we examined expression levels all members samples showed that METTL13 was increased positively correlated with poor prognosis. Moreover, deficiency impaired cell...
Mechanisms underpinning airway epithelial homeostatic maintenance and ways to prevent its dysregulation remain elusive. Herein, we identify that β-catenin phosphorylated at Y489 (p-β-cateninY489) emerges during human squamous lung cancer progression. This led us develop a model of basal stem cell (ABSC) hyperproliferation by driving Wnt/β-catenin signaling, resulting in morphology resembles premalignant lesions loss ciliated differentiation. To small molecules could reverse this process,...
Psoriasis (PSO) is a chronic and systemic inflammatory autoimmune disease associated with atherosclerosis myocardial infarction. Given that both inflammation immune-driven, we sought to expand on known immune biomarkers in psoriasis cohort. Here focus oxidized mitochondrial DNA (ox-mtDNA), product of cells undergoing pyroptosis, including keratinocytes, which was quantified PSO patients non-PSO individuals by ELISA. had significantly higher ox-mtDNA levels compared healthy subjects...
Abstract Background Beta‐defensins (BDs) are antimicrobial peptides secreted upon epithelial injury. Both chemotactic and properties of BDs function as initial steps in host defence prime the adaptive immune system body. Psoriasis, a chronic immune‐mediated inflammatory disease, has both visible cutaneous manifestations well known associations with higher incidence cardiometabolic complications vascular inflammation. Objectives We aimed to investigate circulating expression beta‐defensin‐2...
Introduction: S100A8/A9 is an alarmin protein complex secreted by activated neutrophils in response to inflammation and associated with atherosclerosis cardiovascular disease. Psoriasis a chronic inflammatory disease linked increased levels of S100A8/A9, elevated atherosclerotic risk, premature Lipid-rich necrotic core (LRNC) high-risk coronary plaque feature predictive future events prevalence psoriasis. Whether associates LRNC understudied. We aimed characterize the relationship between...