A5102732183- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Hypoxia, and Metabolism
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Genetic and phenotypic traits in livestock
- Nanoparticle-Based Drug Delivery
- Video Surveillance and Tracking Methods
- Autonomous Vehicle Technology and Safety
- Zebrafish Biomedical Research Applications
- RNA Research and Splicing
- Geotechnical Engineering and Soil Mechanics
- Asphalt Pavement Performance Evaluation
- Infrastructure Maintenance and Monitoring
- Traffic and Road Safety
- Chemokine receptors and signaling
- Prostate Cancer Treatment and Research
- Analog and Mixed-Signal Circuit Design
- Nanoplatforms for cancer theranostics
- Geotechnical Engineering and Underground Structures
- Inflammatory mediators and NSAID effects
- Biomedical Ethics and Regulation
- Peptidase Inhibition and Analysis
Guangzhou Institutes of Biomedicine and Health
2020-2025
Chinese Academy of Sciences
2020-2025
Shandong University
2023-2025
University of Hong Kong
2025
University of Chinese Academy of Sciences
2022-2025
Southern Medical University
2019-2025
Tsinghua University
2023-2025
Harbin Institute of Technology
2025
Guangzhou Medical University
2020-2025
Beihang University
2024
We introduce Noise2Music, where a series of diffusion models is trained to generate high-quality 30-second music clips from text prompts. Two types models, generator model, which generates an intermediate representation conditioned on text, and cascader high-fidelity audio the possibly are utilized in succession music. explore two options for representation, one using spectrogram other with lower fidelity. find that generated not only able faithfully reflect key elements prompt such as...
Detecting pedestrians and predicting future trajectories for them are critical tasks numerous applications, such as autonomous driving. Previous methods either treat the detection prediction separate or simply add a trajectory regression head on top of detector. In this work, we present novel end-to-end two-stage network: Spatio-Temporal-Interactive Network (STINet). addition to 3D geometry modeling pedestrians, model temporal information each pedestrians. To do so, our method predicts both...
Mast cells are being increasingly recognized as critical components in the tumor microenvironment. Protein Kinase D (PKD) is essential for progression of prostate cancer, but its role cancer microenvironment remains poorly understood.The expression PKD, mast and microvessel density were examined by IHC. The clinical significance was determined statistical analyses. biological function PKD underlying mechanisms investigated using vitro vivo models.PKD2/3 contributed to MCs recruitment...
Pyruvate kinase M2 (PKM2) is a key enzyme of glycolysis, which highly expressed in many tumor cells, and has emerged as an important player progression metastasis. However, the functional roles PKM2 metastasis remain elusive. Here we showed that promoted prostate cancer via extracellular-regulated protein (ERK)–cyclooxygenase (COX-2) signaling. Based on public databases, found expression was upregulated positively associated with Further analysis cell migration/invasion...
Genetically engineered macrophages (GEMs) have emerged as an appealing strategy to treat cancers, but they are largely impeded by the cell availability and technical challenges in gene transfer. Here, we develop efficient approach generate large-scale from human induced pluripotent stem cells (hiPSCs). Starting with 1 T150 dish of 10
Chronic stress is well known to promote tumor progression, however, little whether chronic stress-mediated regulation of osteoblasts contributes the migration and invasion metastatic cancer cells.The proliferation, prostate cells were assessed by CCK-8 transwell assay. HIF-1α expression epithelial-mesenchymal transition (EMT) markers examined Western blot. The mRNA level cytokines associated with bone metastasis in EMT PC-3 DU145 performed qRT-PCR. Functional rescue experiment using siRNA,...
Abstract Definitive hematopoiesis generates hematopoietic stem/progenitor cells (HSPCs) that give rise to all mature blood and immune cells, but remains poorly defined in human. Here, we resolve human populations at the earliest stage by single-cell RNA-seq. We characterize distinct molecular profiling between early primitive definitive both embryonic stem cell (hESC) differentiation development. identify CD44 specifically discriminate generate HSPCs from hESCs. The multipotency of...
Accurate understanding and prediction of human behaviors are critical prerequisites for autonomous vehicles, especially in highly dynamic interactive scenarios such as intersections dense urban areas. In this work, we aim at identifying crossing pedestrians predicting their future trajectories. To achieve these goals, not only need the context information road geometry other traffic participants but also fine-grained pose, motion activity, which can be inferred from keypoints. paper, propose...
Studies have indicated that COVID-19 infection may accelerate the aging process in organisms. However, it remains unknown whether contracting affects life expectancy. Furthermore, underlying biological mechanisms behind these findings are still unclear. We conducted a prospective cohort study on 56,504 participants of European ancestry from UK Biobank who reported time and number between January 2020 September 2023. The parental average longevity was used as proxy for their own longevity....
Offshore wind turbines are subjected to long-term cyclic loads, and the seabed materials surrounding foundation susceptible failure, which affects safe construction normal operation of offshore turbines. The existing studies mechanical properties submarine soils focus on accumulation strain liquefaction, few targeted conducted hysteresis loop under loads. Therefore, 78 representative soil samples from four farms tested in study, behaviors different confining pressures CSR investigated....
Abstract Neutrophils are essential innate immune cells with unusual anti-microbial properties while dysfunctions of neutrophils lead to severe health problems such as lethal infections. Generation from human induced pluripotent stem (hiPSCs) is highly promising produce off-the-shelf for transfusion therapies. However, the potencies hiPSCs derived (iNEUs) remain less documented. Here, we develop a scalable approach generate iNEUs in chemical defined condition. display typical neutrophil...
Recently, some methyltransferase-like (METTL) proteins have been found to play crucial roles in the development of acute myeloid leukemia (AML) through mediating RNA modifications, such as METTL3/14/16 mediated N6-methyladenosine (m6A) and METTL1 N7-methylguanosine (m7G). However, other METTL AML progression remain unknown. Here, we examined expression levels all members samples showed that METTL13 was increased positively correlated with poor prognosis. Moreover, deficiency impaired cell...
Abstract A central question in developmental biology is how the germline established. We have studied specification of male germ cells (GCs) within anther 1–3 . Hereby, we focused on potential role mechanics, an aspect development which has been very poorly characterized 2,4 Using a combination live imaging and mechanical measurements, provide evidence that GCs originate special micro-mechanical niche, where inner tissues exert ‘push’ outer cell layers, placing them under compression....