A5100743117- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Adsorption and biosorption for pollutant removal
- Urinary Bladder and Prostate Research
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- Urologic and reproductive health conditions
- Renal Transplantation Outcomes and Treatments
- Urological Disorders and Treatments
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Kidney Stones and Urolithiasis Treatments
- RNA Research and Splicing
- Renal cell carcinoma treatment
- Extraction and Separation Processes
- Inflammatory Biomarkers in Disease Prognosis
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
Soochow University
2016-2025
First Affiliated Hospital of Soochow University
2016-2025
Southeast University
2006-2025
Sun Yat-sen University
2005-2025
Sun Yat-sen University Cancer Center
2005-2025
First Affiliated Hospital of Jinan University
2025
Guangzhou Institutes of Biomedicine and Health
2024
Hunan University of Science and Technology
2024
Changsha University of Science and Technology
2024
Nanchang University
2021-2024
Abstract The severe hypoxia in solid tumors and the vicious aggregation‐caused fluorescence quenching (ACQ) of conventional photosensitizers (PSs) have limited application imaging‐guided photodynamic therapy (PDT), although this has obvious advantages terms its precise spatial–temporal control noninvasive character. PSs featuring type I reactive oxygen species (ROS) based on free radicals novel aggregation‐induced emission (AIE) characteristics (AIE‐PSs) could offer valuable opportunities to...
Abstract Induction of immunogenic cell death (ICD) in tumor combined with immune checkpoint blockade (ICB) therapy is widely developed to improve the efficacy cancer immunotherapy. However, current ICD induced based on apoptosis, i.e., often restricted immunogenicity owing inflammatory quenching that occurs early apoptosis. Recently, pyroptosis demonstrated be a more efficient form, pyroptosis. The contents released during can powerfully activate immunogenicity. Herein, first, it lower doses...
Abstract Immunotherapy has received widespread attention for its effective and long‐term tumor‐eliminating ability. However, immunogenic “cold” tumors, such as prostate cancer (PCa), the low immunogenicity of tumor itself is a serious obstacle to efficacy. Here, this work reports strategy enhance PCa by triggering cascade self‐enhanced ferroptosis in cells, turning from “hot”. This develops transformable self‐assembled peptide TEP‐FFG‐CRApY with alkaline phosphatase (ALP) responsiveness...
Objective: In China, a low-fat diet (LFD) is mainly recommended to help improve blood glucose levels in patients with type 2 diabetes mellitus (T2DM). However, low-carbohydrate (LCD) has been shown be effective improving America and England. A few studies, primarily randomized controlled trials, have reported China as well. Method: Firstly, we designed two ‘six-point formula’ methods, which met the requirements of LCD LFD, respectively. Fifty-six T2DM were recruited randomly allocated group...
The cell membrane is the protecting frontier of cells, which crucial for maintaining integrity, and has a close relationship with growth death. There growing need imaging monitoring in both living dying cells. Herein, we report new amphiphilic tetraphenylethene-based pyridinium salt (TPE-MEM) aggregation-induced emission features discriminatory imaging. fluorogenic probe high yield was synthesized following asymmetric McMurry reaction, Williamson ether synthesis Suzuki coupling, aldol...
Highlights•EBVaICC accounted for 6.6% of ICCs and was associated with EBV latency type I infection clonal isolates.•EBVaICChas unique characteristics related to etiology, clinicopathology molecular genetics.•Both PD-1 PD-L1 in tumor-infiltrating lymphocytes tumor cells are overexpressed EBVaICC.•Patients EBVaICC may respond well immune checkpoint inhibitors.•The lymphoepithelioma-like subtype is favorable survival.AbstractBackground & AimsLittle known about Epstein-Barr virus...
The implementation of cisplatin-based neoadjuvant chemotherapy (NAC) plays a key role in conjunction with surgical resection preventing bladder cancer progression and recurrence. However, the significant dose-dependent toxic side effects NAC are still major challenge. To solve this problem, we developed photoenhanced (PECC) strategy based on AIEgen ((E)-3-(2-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)-1,1-dimethyl-1H-3λ4-benzo[e]indol-3-yl)propane-1-sulfonate), which is abbreviated...
With the advent of era precision medicine, prostate‐specific membrane antigen (PSMA)‐targeted theranostic strategies have had a profound impact on prostate cancer research. As specific target, PSMA is not only widely expressed in tissues but its expression also correlated with tumor aggressiveness. Because noninvasiveness, real‐time nature, high sensitivity, and low side effects phototheranostics, recent years, there has been rapid advancement PSMA‐targeted such as near‐infrared fluorescence...
Prostate cancer (PCa) is a frustrating immunogenic "cold" tumor and generally receives unsatisfied immunotherapy outcomes in the clinic. Pyroptosis an excellent cell death form that can effectively activate antitumor immune response, promote cytotoxic T-lymphocyte infiltration, convert tumors from to "hot." However, vivo application of pyroptosis drugs seriously limited, upregulation PD-L1 caused by photo-immunotherapy further promotes escape. Herein, new nano-photosensitizer (YBS-BMS...
Background and Aims: NASH-HCC is inherently resistant to immune checkpoint blockade, but its tumor microenvironment largely unknown. Approach Results: We applied the imaging mass cytometry construct a spatially resolved single-cell atlas from formalin-fixed paraffin-embedded tissue sections patients with NASH-HCC, virus-HCC (HBV-HCC HCV-HCC), healthy donors. Based on 35 biomarkers, over 750,000 individual cells were categorized into 13 distinct cell types, together expression of key...
Clear cell renal carcinoma (ccRCC) is a common clinical tumor of the urinary system. The lack effective diagnostic and treatment options poses serious challenge to treatment. Therefore, identifying molecular targets has become one potential means treat this disease. Firstly, analysis TCGA database found that PLAC1 was abnormally highly expressed in ccRCC negatively correlated with patient prognosis. Western blotting immunofluorescence experiments further verified patients, knockdown...
Iatrogenic ureteral injury is a dreaded complication of abdominal and pelvic surgeries, thus, intraoperative identification ureters paramount importance but lacks efficient methods probes. Herein, we used near-infrared II (NIR-II, 1000–1700 nm) fluorescence imaging with advantages higher spatial resolution, deeper tissue penetration, lower light scattering, less autofluorescence to identify by aggregation-induced emission luminogen dots (AIE dots). The injuries common diseases can be...
Abstract Purpose To investigate the performance of magnetic resonance imaging (MRI)-based radiomics models for benign and malignant prostate lesion discrimination extracapsular extension (ECE) positive surgical margins (PSM) prediction. Methods materials In total, 459 patients who underwent multiparametric MRI (mpMRI) before biopsy were included. Radiomic features extracted from both T2-weighted (T2WI) apparent diffusion coefficient (ADC). Patients divided into different training sets...
Lysine (K)-specific demethylase 6B (KDM6B), a stress-inducible H3K27me3 demethylase, plays oncogenic or antitumoral roles in malignant tumors depending on the type of tumor cell. However, how this histone modifier affects progression prostate cancer (PCa) is still unknown. Here we analyzed sequenced gene expression data and tissue microarray to explore features prognostic value KDM6B PCa. Further, performed vitro cell biological experiments vivo nude mouse models reveal function, upstream...
Ferroptosis is a newly found non-apoptotic forms of cell death that plays an important role in tumors. However, the prognostic value ferroptosis-related genes (FRG) bladder cancer (BLCA) have not been well examined.FRG data and clinical information were collected from The Cancer Genome Atlas (TCGA). Then, significantly different FRGs investigated by functional enrichment analyses. FRG signature was identified univariate cox regression least absolute shrinkage selection operator (LASSO)...
Abstract With the development of aggregation‐induced emission (AIE) materials, drawbacks conventional fluorescence materials subjected to aggregation‐caused quenching (ACQ) have been resolved. This has allowed for improvement novel AIE fluorescent that exhibit enhanced photostability, a higher signal‐to‐noise ratio, and better imaging quality. Meanwhile, phototherapeutic effect garnered widespread attention in realm tumor treatment. The distinct physiological anatomical characteristics...
A high performance ratiometric fluorescent probe, namely TPE-RNS, has been developed for detecting exogenous and endogenous HClO/ClO<sup>−</sup> in living cells discriminating cancer from normal cells.
Preoperative prediction of extracapsular extension (ECE) prostate cancer (PCa) is important to guide clinical decision-making and improve patient prognosis.To investigate the value multiparametric magnetic resonance imaging (mpMRI)-based peritumoral radiomics for preoperative presence ECE.Retrospective.Two hundred eighty-four patients with PCa from two centers (center 1: 226 patients; center 2: 58 patients). Cases 1 were randomly divided into training (158 patients) internal validation (68...
The present study aimed to investigate the role and underlying mechanisms of long non-coding RNA (lncRNA) muscleblind-like 1 antisense (MBNL1-AS1) in progression Prostate cancer (PCa). MBNL1-AS1 microRNA (miR)-181a-5p expression PCa tissues several human cell lines were analyzed, respectively, using StarBasev3.0 project RT-qPCR assay. After overexpression, proliferation, invasion migration were, evaluated CCK-8, colony formation, transwell wound healing assays. Dual luciferase assay used for...
Three-dimensional (3D) culture has been reported to increase the therapeutic potential of mesenchymal stem cells (MSCs). The present study assessed efficacy extracellular vesicles (EVs) from 3D cultures human placental MSCs (hPMSCs) for acute kidney injury (AKI).The supernatants monolayer (2D) and hPMSCs were ultra-centrifuged EVs isolation. C57BL/6 male mice submitted 45 min bilateral ischemia kidney, followed by renal intra-capsular administration within a 72 h reperfusion period....
Genetically engineered macrophages (GEMs) have emerged as an appealing strategy to treat cancers, but they are largely impeded by the cell availability and technical challenges in gene transfer. Here, we develop efficient approach generate large-scale from human induced pluripotent stem cells (hiPSCs). Starting with 1 T150 dish of 10