A5091707482- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Nerve injury and regeneration
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Kruppel-like factors research
- Phagocytosis and Immune Regulation
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Mechanisms of cancer metastasis
- 14-3-3 protein interactions
- Histone Deacetylase Inhibitors Research
- Nuclear Receptors and Signaling
- Neurological Disease Mechanisms and Treatments
- Molecular Biology Techniques and Applications
- Traditional Chinese Medicine Analysis
Affiliated Zhongshan Hospital of Dalian University
2024
University of Michigan
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
Lishui City People's Hospital
2020-2021
Wenzhou Medical University
2016-2021
Shanghai Eighth People Hospital
2010-2021
Qingdao University
2018
Affiliated Hospital of Qingdao University
2018
Xinjiang Medical University
2018
Jining First People's Hospital
2017
Abstract The neuroprotective effect and molecular mechanisms underlying preconditioning with N ‐methyl‐D‐aspartate (NMDA) in cultured hippocampal neurons have not been described. Pre‐incubation subtoxic concentrations of the endogenous neurotransmitter glutamate protects vulnerable against NMDA receptor‐mediated excitotoxicity. As a result physiological preconditioning, significantly antagonizes neurotoxicity resulting from subsequent exposure to an excitotoxic concentration glutamate....
Lysine (K)-specific demethylase 6B (KDM6B), a stress-inducible H3K27me3 demethylase, plays oncogenic or antitumoral roles in malignant tumors depending on the type of tumor cell. However, how this histone modifier affects progression prostate cancer (PCa) is still unknown. Here we analyzed sequenced gene expression data and tissue microarray to explore features prognostic value KDM6B PCa. Further, performed vitro cell biological experiments vivo nude mouse models reveal function, upstream...
Brain-derived neurotrophic factor (BDNF), via activation of TrkB receptors, mediates vital physiological functions in the brain, ranging from neuronal survival to synaptic plasticity, and has been implicated pathophysiology neurodegenerative disorders. Although transcriptional regulation BDNF gene ( Bdnf ) extensively studied, much remains be understood. We discovered a sequence within promoter 4 that binds basic helix-loop-helix protein BHLHB2 is target for BHLHB2-mediated repression. NMDA...
Abstract Purpose Our study is to examine astrocyte‐elevated gene‐1 (AEG‐1) expression in triple‐negative breast cancer and determine whether it associated with vascular endothelial growth factor (VEGF), microvessel density (MVD), clinicopathological parameters poor survival. Methods Specimens from 125 patients cancers were investigated by immunohistochemistry for MVD, AEG‐1 VEGF expression. Correlations between the of AEG‐1, VEGF, various factors including survival status studied. Results...
Endothelial cell injury and subsequent death play an essential role in the pathogenesis of atherosclerosis. Autophagy endothelial cells has a protective against development atherosclerosis, whereas molecular regulation autophagy is unclear. MicroRNA-30 (miR-30) known suppressor some biological processes, while it unknown whether this regulatory axis may be similarly involved Here, we aimed to answer these questions current study.We examined levels ApoE (-/-) mice suppled with high-fat diet...
Endothelial cell injury and subsequent apoptosis play a key role in the development pathogenesis of atherosclerosis, which is hallmarked by dysregulated lipid homeostasis, aberrant immunity inflammation, plaque-instability-associated coronary occlusion. Nevertheless, our understanding mechanisms underlying endothelial still limited. MicroRNA-429 (miR-29) known cancer suppressor that promotes apoptosis. However, it unknown whether miR-429 may be involved atherosclerosis through similar...
Lysine (K)-specific demethylase 6A (KDM6A) is a frequently mutated tumor suppressor gene in pancreatic ductal adenocarcinoma (PDAC). However, the impact of KDM6A loss on PDAC immune microenvironment not known. This study used genetically engineered, pancreas-specific Kdm6a knockout (KO) mouse model and human tissue samples to demonstrate that correlates with increased tumor-associated neutrophils neutrophil extracellular traps (NET) formation, which are known contribute progression....
To determine the epigenetic events associated with NMDA receptor-mediated activation of brain-derived neurotrophic factor gene (Bdnf) promoter 1 by hippocampal neurons in culture, we screened 12 loci across 4.5 kb genomic DNA 5' transcription start site (TSS) rat Bdnf for specific changes histone modification and binding following receptor stimulation. Chromatin immunoprecipitation (ChIP) assays showed that stimulation produced a durable, time-dependent decrease H3 at lysine 9 dimethylation...
Tanshinone II-A is an alcohol extract of the root traditional Chinese medicinal plant Salvia miltiorrhiza Bunge, whose effects and mechanism in tumor metastasis are still unclear. The aim this study was to investigate tanshinone on invasion human hepatocellular carcinoma (HCC) its possible action.The HCC cell lines HepG2 SMMC-7721 were treated with at different doses. Invasion cells examined by vitro vivo assays. molecular mechanisms for inhibiting investigated Western blot gelatin...
Emerging evidence are accumulating that long noncoding RNAs (lncRNAs) have recently been identified to participate in various cellular processes. Terminal differentiation induced ncRNA (TINCR) is a newly lncRNA with its functional roles not fully elucidated human malignancy. The current study aims identify the clinical significance of TINCR prognosis and malignant progression hepatocellular carcinoma (HCC). expression HCC specimens at stages tumorigenesis were measured by quantitative...
Histone acetylation/deacetylation is a central mechanism for regulating transcription through chromatin remodeling. The brain-derived neurotrophic factor gene (Bdnf) regulated in part An inhibitor of histone deacetylase (HDAC) activity, Trichostatin A (TSA), has differential effects on two activation dependent regions the Bdnf physically linked to sites exons 1 and 4. We determined that TSA treatment cultures hippocampal neurons produced stronger response at promoter 1. Transcriptional...
Histone acetyltransferases (HATs) play vital functions in the tumorigenesis of many solid organ malignancies. We previously screened a human HATs cDNA library and identified Tat-interactive protein-60KDa (TIP60) as candidate critical origination lung cancer. In this study, our data suggested that overexpression TIP60 inhibited cell viability A549 H1299 cells since day 2. Compared to control group, these two cancer was by 25% 19% at 6 with TIP60. It increased 36% 26% when knockdown for days....
Gastric cancer is one of the most common malignancies and leading causes cancer-related death worldwide. An increasing number evidence has revealed that gastric tumorigenesis a multistage pathological state, epigenetic alterations are considered to play critical roles in etiology cancer. Lysine-specific demethylase-1, histone demethylase, been linked malignancy several human cancers epigenetically regulate many tumor suppressor genes during progression. However, its role underlying targets...