A5101567935- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- TGF-β signaling in diseases
- RNA modifications and cancer
- Mechanisms of cancer metastasis
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- RNA and protein synthesis mechanisms
- HER2/EGFR in Cancer Research
- RNA Research and Splicing
- Natural Compounds in Disease Treatment
- Cancer Cells and Metastasis
- Microtubule and mitosis dynamics
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- Renal Diseases and Glomerulopathies
- Kruppel-like factors research
- Complement system in diseases
- Breast Cancer Treatment Studies
- Genetic factors in colorectal cancer
- Cancer and Skin Lesions
- Gastrointestinal Tumor Research and Treatment
- Molecular Biology Techniques and Applications
- Phytochemical compounds biological activities
Harbin Medical University
2014-2024
Third Affiliated Hospital of Harbin Medical University
2012-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2023
Reha Rheinfelden
2016
Yamagata Research Institute Of Technology
2016
Abstract Purpose Our study is to examine astrocyte‐elevated gene‐1 (AEG‐1) expression in triple‐negative breast cancer and determine whether it associated with vascular endothelial growth factor (VEGF), microvessel density (MVD), clinicopathological parameters poor survival. Methods Specimens from 125 patients cancers were investigated by immunohistochemistry for MVD, AEG‐1 VEGF expression. Correlations between the of AEG‐1, VEGF, various factors including survival status studied. Results...
In mammals, the signal transducer and activator of transcription (STAT) protein processes mitochondria importation targets respiratory complexes, triggers reactive oxygen species (ROS) generation, which conversely rapidly initiates activation STAT. Interferon (IFN) administration increases cancer cell apoptosis via STAT ROS accumulation. However, existence a STAT-ROS cycle how it affects IFN‑induced cellular are unclear. present study, we used MCF7 breast cells confirmed that combination...
ING4, a new member of the ING (inhibitor growth) family tumour suppressor genes, has been found to be deleted or down-regulated in gliomas, breast tumours, and head neck squamous cell carcinomas. The goal present study was investigate whether expression alternative splicing ING4 transcripts are involved initiation progression stomach adenocarcinoma. mRNA protein examined gastric adenocarcinoma tissues human lines by RT-PCR, real-time tissue microarray immunohistochemistry, western blot...
Objective: Despite advances in chemotherapy and cytoreductive surgery, ovarian cancer remains the most lethal gynecological malignancy with a 5-year survival rate of 25% to 30% advanced stage disease. Our purpose is evaluate whether astrocyte elevated gene-1 (AEG-1) novel predictor peritoneal dissemination lymph node metastasis epithelial (EOC), which was not previously studied by others. Materials Methods: Through immunohistochemical Western blot analysis, AEG-1 expression evaluated 25...
Breast cancers are heterogeneous and complex diseases, subtypes of breast may involve unique molecular mechanisms. The p16INK4a p53 pathways two the major involved in control cell cycle. They also play key roles tumorigenesis. However, whether these differ cancer is unclear. Therefore, p16 expression were investigated different to ascertain their contributions cancers. A total 400 cases non-invasive ductal carcinoma situ (DCIS) invasive (IDC), including luminal-A, luminal-B, Her-2,...
Abstract Mammography is used to detect breast cancer (BC), but its sensitivity limited, especially for dense breasts. Circulating cell-free DNA (cfDNA) methylation tests expected compensate the deficiency of mammography. We derived a specific panel markers based on computational analysis profiles from The Cancer Genome Atlas (TCGA). Through training ( n = 160) and validation set 69), we developed diagnostic prediction model with 26 markers, which yielded 89.37% specificity 100%...
Epigenetic silencing of secreted frizzled-related protein (SFRP) genes, antagonists the WNT pathway, contributes to pathogenesis several cancers including non-small cell lung cancer (NSCLC). We hypothesize that methylation analysis SFRPs family could improve their use as a panel biomarkers for diagnosing and staging NSCLC in China. The expression four SFRP members (SFRP1, 2, 4, 5) samples was screened by RT-PCR quantitative real-time PCR. Only SFRP1 significantly downregulated NSCLC,...
Abstract Aim Current estimates of the human epidermal growth factor receptor 2 (HER2)‐positivity rate in breast cancer are largely based on studies from United States, Europe and Australia, might not reflect among patients Asia. The primary aim this study was to conduct a clinical audit laboratories across eight countries Asia determine incidence HER2‐positive region. Methods Pathology submitted data cancers consecutively tested for HER2 over two‐year period. proportion HER2‐positive,...
<h3>Objective:</h3> To assess the expression of astrocyte elevated gene-1 (AEG-1) in different endometrial specimens and to investigate its relationship with clinicopathological features impact on patient outcome. <h3>Materials Methods:</h3> By Western blot analysis, we investigated AEG-1 paired tissues adjacent nontumor same patients (n = 4). Immunohistochemistry analysis was used determine levels protein 35 normal endometrium, 40 atypical hyperplasia, 174 cancers. The correlation between...
Androgen receptor (AR) plays an important role in male breast cancer (MBC). Additionally, endocrine therapy is the most treatment oestrogen (ER)-positive advanced cancer. This study was aimed to investigate of AR MBC and prognosis analyse relationship between effect tamoxifen patients.AR protein levels other tumour characteristics (e.g. expression ER (ESR1), PR (PGR), AR, HER2 (ERBB2) Ki-67 (MKI67)) tissue from 102 patients were determined using immunohistochemical analysis. status...
The aim of this study is to investigate the expression ribosome‐binding protein 1 ( RRBP 1) in invasive breast cancer and analyze its relationship clinical features prognosis. was studied using real‐time quantitative PCR western blotting pair‐matched samples immunohistochemical staining a tissue microarray. Then correlation between clinicopathologic analyzed. mRNA were significantly increased tissues compared with normal tissues. level proved be positively related histological grade P =...
To investigate the role of AEG-1 in glycolysis and tumorigenesis, we construct myc-AEG-1 expression vector demonstrate a novel mechanism that may increase activity AMPK by Thr172 phosphorylation. The higher levels colorectal carcinoma cells were found but showed significant difference different cell lines. study cells, was constructed transfected into NCM460 colonic epithelial cells. We observed consistent increasing glucose consumption lactate production, typical features anaerobic...
// Bingshu Xia 1 , Ming Shan Ji Wang Zhenbin Zhong Jingshu Geng 2 Xiaohui He 3 Tung Vu 4 Dekai Zhang Da Pang 1, 5 Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China Pathology, Records, Center for Infectious and Inflammatory Diseases, Institute Biosciences Technology, Texas A&M Health Science Center, Houston, Texas, 77030, USA Heilongjiang Academy Sciences, Province, 150086, Correspondence to: Pang, email: pangda@ems.hrbmu.edu.cn Zhang,...
This study was to examine the breast cancer-overexpressed gene 1 (BCOX1) expression in invasive ductal carcinomas (IDC) of and its value prognosis disease. The levels BCOX1 491 paired IDC surrounding non-tumor tissues as well 40 fresh specimens were evaluated by tissue microarray, immunohistochemistry quantitative RT-PCR. potential associations high with clinicopathological variables overall survival these patients analyzed. relative mRNA transcripts significantly higher than that...
Abstract Background Tongue squamous cell carcinoma (TSCC) is the most common oral cavity cancer, and p16 immunohistochemistry an exact available tool in prognostic predictive characterization of cancers head neck. Microorganisms have a close relationship with development TSCC. However, association between bacteria status has not been well defined case Compared traditional clinical microbial collection methods, formalin-fixed paraffin-embedded (FFPE) tissue samples several advantages. Methods...
Astrocyte elevated gene-1 (AEG-1), a novel tumor-associated gene, was found overexpressed in many tumors. Therefore, our purpose is to estimate whether AEG-1 overexpression predictor of prognostic marker metastatic ovarian Immunohistochemistry used tumors from 102 samples. The association between expression and prognosis estimated by univariate multivariate survival analyses with Cox regression. log-rank test identify any differences the two groups. median overall progression-free rates...
Previous studies have indicated that caveolin-1 (Cav-1) is able to bind the signal transduction factor epidermal growth receptor (EGFR) regulate its tyrosine kinase activity. The aim of present study was evaluate clinical significance Cav-1 gene expression in association with EGFR patients breast cancer. Primary cancer samples from 306 were analyzed for and using immunohistochemistry, assessed multivariate Cox regression analysis, Kaplan-Meier estimator curves log-rank test. Stromal...
The androgen receptor (AR) expression and the CAG repeat length within AR gene appear to be involved in carcinogenesis of male breast carcinoma (MBC). Although phenotypic differences have been observed between MBC normal control group gene, there is lack correlation analysis MBC. purpose study was investigate prognostic value lengths protein expression.81 tumor tissues were used for immunostaining determination 80 controls analyzed with gene. relation clinicopathological factors...
Colorectal cancer (CRC) is mainly caused by chromosomal instability (CIN) and microsatellite (MSI). The RAS RAF genes are essential components of the CIN pathway, several studies have found that mutations associated with MSI status in CRC. Here, we examined these three factors CRC Northeast China aimed to reveal new details relationship between status.This study involved 290 patients who had or gene mutation detected using fluorescence-based allele-specific polymerase chain reaction Sanger...