A5101631238- Antimicrobial agents and applications
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- Advanced Nanomaterials in Catalysis
- Antimicrobial Peptides and Activities
- Biosensors and Analytical Detection
- Congenital limb and hand anomalies
- Ionic liquids properties and applications
- Genomics and Chromatin Dynamics
- Pharmaceutical and Antibiotic Environmental Impacts
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Nanoparticles: synthesis and applications
- Histone Deacetylase Inhibitors Research
- Wnt/β-catenin signaling in development and cancer
- Immune Response and Inflammation
- Advanced Photocatalysis Techniques
- Polydiacetylene-based materials and applications
- Cancer-related molecular mechanisms research
- Microfluidic and Bio-sensing Technologies
- Acne and Rosacea Treatments and Effects
- Clinical Nutrition and Gastroenterology
- Polymer Synthesis and Characterization
Sun Yat-sen University
2015-2024
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Zhongshan Hospital
2015-2024
Fudan University
2015-2024
Center for Excellence in Molecular Cell Science
2010-2024
Shanghai Institutes for Biological Sciences
2010-2024
Robert Bosch (Germany)
2024
Donghua University
2021
University of Chinese Academy of Sciences
2020
Shanghai Jiao Tong University
2009-2016
The structure–antibacterial activity relationship between the small molecular compounds and polymers are still elusive. Here, imidazolium-type ionic liquid (IL) monomers their corresponding poly(ionic liquids) (PILs) liquid) membranes were synthesized. effect of chemical structure, including carbon chain length substitution at N3 position charge density cations (mono- or bis-imidazolium) on antimicrobial activities against both Escherichia coli (E. coli) Staphylococcus aureus (S. aureus) was...
Pyrrolidinium-type small molecule ionic liquids (ILs), poly(ionic liquid) (PIL) homopolymers, and their corresponding PIL membranes were synthesized used for antibacterial applications. The influences of substitutions at the N position pyrrolidinium cation on antimicrobial activities against both Staphylococcus aureus (S. aureus) Escherichia coli (E. coli) studied by minimum inhibitory concentration (MIC). efficiency ILs homopolymers increased with increase alkyl chain length substitutions....
The development of materials with intrinsically antimicrobial activities has attracted great interest. Herein, we report the synthesis free-standing and robust poly(ionic liquid) (PIL) membranes high antibacterial by in situ photo-cross-linking an ionic liquid monomer followed anion-exchange amino acid (l-proline (Pro) or l-tryptophan (Trp)). resultant PIL-based excellent robustness exhibit properties against both Gram-negative Escherichia coli (E. coli) Gram-positive Staphylococcus aureus...
Imidazolium (Im), quaternary ammonium (Qa), and 1,4-diazabicyclo[2.2.2]octane-1,4-diium (DABCO-diium) cation-based small molecule cationic compounds their corresponding side-chain/main-chain polymers were synthesized.
Herein, a series of quaternary ammonium (Qa) or imidazolium (Im) cation-based poly(ionic liquid) (PIL) membranes and their corresponding zinc ion coordinated PIL were synthesized. The effects chemical structure, including organic cations, alkyl side chain substitution, atoms on the antimicrobial activities against Escherichia coli, Staphylococcus aureus, Candida albicans investigated. Zn-containing show higher antibacterial compared to those pristine due synergistic attributes both cations...
Gram-negative bacteria, containing toxic proinflammatory and pyrogenic substances [endotoxin or lipopolysaccharide (LPS)], can lead to infection associated serious diseases, such as sepsis septic shock. Development of antimicrobial materials with intrinsically endotoxin adsorption activity prevent the release bacterial components while killing bacteria. Herein, a series imidazolium-type polyurethane (PU) foams properties were synthesized. The content effects cationic moieties on activities...
Abstract Resistant bacteria have become a global threat. Even if are killed, their carried drug‐resistant genes can remain in the environment and spread to other microbes via horizontal gene transfer. Development of antimicrobial materials with intrinsic break down activity prevent dissemination released from dead bacteria. Herein, imidazolium type poly(ionic liquid) (PIL)/cerium (IV) ion‐based electrospun nanofibrous membranes (PIL‐Ce) synthesized. The effects PIL Ce moieties on properties...
Imidazolium-type metal-containing ionic liquid (IL) monomers and their corresponding poly(ionic liquid) (PIL) membranes coordinated with CuCl2 (PILM-Cu), FeCl3 (PILM-Fe), or ZnCl2 (PILM-Zn) were synthesized. The effect of metal ions on the antimicrobial activities against both Staphylococcus aureus (S. aureus) Escherichia coli (E. coli) was investigated. Compared pristine PILM-Br membrane, PILM-Cu, PILM-Fe, PILM-Zn exhibit enhanced antibacterial due to attributes imidazolium cations anions....
Fluorescent imidazolium-type poly(ionic liquid)s (PIL)s were synthesized by anion exchange of bromide (Br-) in poly(3-butyl-1-vinylimidazolium bromide) (PIL-Br) with a fluorescent anion, namely, 3-(4-(1,2,2-triphenylvinyl)phenoxy)propane-1-sulfonate (TPESO3-). Such an provided antibacterial PILs aggregation-induced emission (AIE) properties that simultaneously kill and image bacteria. These fluorescence could be regulated controlling the Br-/TPESO3- ratio. The intensity increases as this...
Progression of critically ill patients from Systemic Inflammatory Response Syndrome (SIRS) to Multiple Organ Dysfunction (MODS) accounts for more than 75% deaths in adult surgical intensive care units. Currently, there is no practical clinical technique predict the progression SIRS or MODS. In this report, we describe an NMR-based metabonomic method aid detection these conditions based on abnormal metabolic signatures. We applied pattern recognition methods analyze one-dimensional (1)H NMR...
Abstract Jumonji C‐terminal (JmjC) domain‐containing proteins are protein hydroxylases and histone demethylases that control gene expression. 6 (Jmjd6) is indispensable for embryonic development has both arginine demethylase lysyl‐hydroxylase activities. The undergoes post‐translational homo‐oligomerization, but the underlying mechanism remains unknown. In this study, we examined enzymatic activity of Jmjd6 uncovered its homo‐oligomerization. An in vitro assay monitored by matrix‐assisted...
Bacteria induced infection remains a serious medical hazard to humans. Antibacterial polymeric materials, which can kill or inhibit bacteria by disrupting cell membranes, inhibiting certain enzymes, interfering with the transcription synthesis of DNA RNA, have been applied reduce microbial drug resistance. Herein, amino acid-based ionic liquids (ILs) and poly(ionic liquid) (PIL) membranes were synthesized used as antibacterial materials treat skin wounds infected methicillin-resistant...
Abstract The escalating spread of drug‐resistant bacteria and viruses is a grave concern for global health. Nucleic acids dominate the drug‐resistance transmission pathogenic microbes. Here, imidazolium‐type poly(ionic liquid)/porphyrin (PIL‐P) based electrospun nanofibrous membrane its cerium (IV) ion complex (PIL‐P‐Ce) are developed. obtained PIL‐P‐Ce exhibits high stable efficiency in eradicating various microorganisms (bacteria, fungi, viruses) decomposing microbial antibiotic resistance...
Polycationic polymers have been widely used as antimicrobial materials because of their broad spectrum activity and potential use new antibiotics. Herein, we report the synthesis polyanionic membranes by in situ photo-cross-linking a sulfate based anionic monomer, followed cation-exchange with organic (quaternary ammonium or imidazolium) metal (Ag+, Cu2+, Fe3+, Zn2+, Na+, K+) cations. The resultant show high antibacterial activities against both bacteria (Escherichia coli, Staphylococcus...
Macrodactyly is a disabling congenital disease characterized by overgrowth of soft tissues and bones, which leads to finger enlargement joint deformity. The mechanism bone in macrodactyly was rarely understood. In our study manifestations three patients were analyzed micro-CT. PIK3CA mutation detected next-generation sequencing (NGS) tumor gene-panel. PI3K/AKT/mTOR pathway activation target genes analyzed. osteogenic potential macrodactyly-derived marrow mesenchymal stem cells (MAC-BMSCs)...
Histone methyl groups can be removed by demethylases. Although LSD1 and JmjC domain-containing proteins have been identified as histone demethylases, enzymes for many methylation states or sites are still unknown. Here, we perform a screening of cDNA library containing 2,500 nuclear identify hHR23A H4K20 demethylase. Overexpression reduces the levels H4K20me1/2/3 in cells. In vitro, specifically demethylates generates formaldehyde. The enzymatic activity requires Fe(II) α-ketoglutarate...
Abstract Background Sepsis is the overwhelming inflammatory response to infection, in which nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome plays a crucial role. Shingosine-1-phosphate reported evoke NLRP3 activation. Sphingosine kinase 1 (SphK1) major that catalyzes bioactive lipid shingosine-1–phosphate formation and its role sepsis remains uncertain. The authors hypothesize SphK1 elicits activation exacerbates sepsis. Methods...