A5006027116- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- 3D Printing in Biomedical Research
- Extracellular vesicles in disease
- Advanced Biosensing Techniques and Applications
- RNA modifications and cancer
- Advanced Sensor and Energy Harvesting Materials
- Analytical Chemistry and Sensors
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- Electrowetting and Microfluidic Technologies
- Electrochemical sensors and biosensors
- Epigenetics and DNA Methylation
- Anodic Oxide Films and Nanostructures
- RNA Interference and Gene Delivery
- Graphene research and applications
- Nanopore and Nanochannel Transport Studies
- Nanowire Synthesis and Applications
- Graphene and Nanomaterials Applications
- Bacteriophages and microbial interactions
- Hepatitis B Virus Studies
State Key Laboratory of Transducer Technology
2016-2025
Chinese Academy of Sciences
2013-2025
Shanghai Institute of Microsystem and Information Technology
2016-2025
University of Chinese Academy of Sciences
2017-2024
Ningbo Dahongying University
2024
Peking University Shenzhen Hospital
2019
Jinan Central Hospital
2014-2018
Shandong University
2014-2018
Academia Sinica
2015
University of Leeds
2008
Herein, we describe a novel approach for rapid, label-free and specific DNA detection by applying rolling circle amplification (RCA) based on silicon nanowire field-effect transistor (SiNW-FET) the first time. Highly responsive SiNWs were fabricated with complementary metal oxide semiconductor (CMOS) compatible anisotropic self-stop etching technique which eliminated need hybrid method. The probe was immobilized surface of SiNW, followed sandwich hybridization perfectly matched target RCA...
A direct, rapid, highly sensitive and specific biosensor for detection of cancer biomarkers is desirable in early diagnosis prognosis cancer. However, the existing methods detecting suffer from poor sensitivity as well requirement enzymatic labeling or nanoparticle conjugations. Here, we proposed a two-channel PDMS microfluidic integrated CMOS-compatible silicon nanowire (SiNW) field-effect transistor arrays with potentially single use label-free ultrasensitive electrical biomarkers. The...
Abstract A simple, convenient, and highly sensitive bio-interface for graphene field-effect transistors (GFETs) based on multifunctional nano-denatured bovine serum albumin (nano-dBSA) functionalization was developed to target cancer biomarkers. The novel graphene–protein bioelectronic interface constructed by heating denature native BSA the substrate surface. formed nano-dBSA film served as cross-linker immobilize monoclonal antibody against carcinoembryonic antigen (anti-CEA mAb) channel...
Abstract Tumor-derived exosomes are actively involved in cancer progression and metastasis have emerged as a promising marker for diagnosis liquid biopsy. Because of their nanoscale size, complex biogenesis, methodological limitations related to exosome isolation detection, advancements analysis remain slow. Microfluidic technology offers better analytic approach compared with conventional methods. Here, we developed bead-based microarray multiplexed tumor detection. Using this method,...
In recent years, wearable sensors have revolutionized health monitoring by enabling continuous, real-time tracking of human and performance. These noninvasive devices are usually designed to monitor physical state biochemical markers. However, enhancing their functionalities often demands intricate customization designers additional expenses for users. Here, we present a strategy using assembled modular circuits customize wearables. The can be effortlessly reconfigured meet various specific...