A5035426620- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Bacterial biofilms and quorum sensing
- Genetic Associations and Epidemiology
- Cancer, Hypoxia, and Metabolism
- Antimicrobial Peptides and Activities
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- RNA and protein synthesis mechanisms
- Cell Adhesion Molecules Research
- Biochemical and Structural Characterization
- Reproductive System and Pregnancy
- RNA Research and Splicing
- Blood disorders and treatments
- Mitochondrial Function and Pathology
- Gene expression and cancer classification
- Lymphoma Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- DNA Repair Mechanisms
- Protein Hydrolysis and Bioactive Peptides
- Bacteriophages and microbial interactions
- ATP Synthase and ATPases Research
- Platelet Disorders and Treatments
- Genetic Mapping and Diversity in Plants and Animals
Cancer Research UK
2021-2025
Cancer Research UK Cambridge Center
2021-2025
Guizhou Normal University
2025
Shanxi Medical University
2025
Taian City Central Hospital
2025
Second Hospital of Shanxi Medical University
2025
University of Cambridge
2021-2025
First Affiliated Hospital of Kunming Medical University
2008-2024
Kunming Medical University
2008-2024
Osaka University
2024
Salmonella enterica serovar Typhimurium is a main cause of bacterial food-borne diseases. As can form biofilms in which it better protected against antimicrobial agents on wide diversity surfaces, interest to explore ways inhibit biofilm formation. Brominated furanones, originally extracted from the marine alga Delisea pulchra, are known interfere with formation several pathogens. In this study, we have synthesized small focused library brominated furanones and tested their activity S. We...
For a comprehensive understanding of cells or tissues, it is important to enable multiple studies under the controllable microenvironment chip. In this report, we present an integrated microfluidic cell culture platform in which endothelial (ECs) are static conditions exposed pulsatile and oscillatory shear stress. Through integration microgap, self-contained flow loop, pneumatic pumps, valves, novel chip achieved functions: fluid circulation, trapping, culture, formation ECs barrier, adding...
Long non-coding RNAs (lncRNAs), representing a large proportion of transcripts across the human genome, are evolutionally conserved and biologically functional. At least one-third phenotype-related loci identified by genome-wide association studies (GWAS) mapped to intervals. However, relationships between lncRNAs largely unknown. Utilizing 1000 Genomes data, we compared single-nucleotide polymorphisms (SNPs) within sequences lncRNA protein-coding genes as defined in Ensembl database. We...
AGS-16C3F is an antibody-drug conjugate (ADC) against ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) containing the mcMMAF linker-payload currently in development for treatment of metastatic renal cell carcinoma. and other ADCs have been reported to cause ocular toxicity patients by unknown mechanisms. To investigate this toxicity, we developed vitro assay using human corneal epithelial cells (HCEC) show that HCECs internalized macropinocytosis, causing inhibition proliferation....
DNA replication errors that persist as mismatch mutations make up the molecular fingerprint of repair (MMR)-deficient tumors and convey them with resistance to standard therapy. Using whole-genome whole-exome sequencing, we here confirm an MMR-deficient mutation signature is distinct from other tumor genomes, but surprisingly similar germ-line DNA, indicating a substantial fraction human genetic variation arises through escaping MMR. Moreover, identify large set recurrent indels may serve...
Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an attempt identify the biologically relevant variants, we analyzed 909 genetic variants across 103,991 individuals and control from 52 Breast Cancer Association Consortium. Multiple logistic regression analyses identified three independent signals: strongest associations were 15 correlated (iCHAV1), where minor allele best candidate,...
Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancer and estradiol (E 2 ) concentrations. We analyzed 2937 single nucleotide polymorphisms (SNPs) in 6608 cases 37 925 controls report the first genome wide-significant association between a SNP (rs727479 intron 2, P =4.8×10 −11 ). rs727479 was also among those most strongly circulating E concentrations 2767 post-menopausal ( =7.4×10 −8 The observed odds ratio per A-allele (1.15, CI=1.11–1.21) is...
Neutropenia is a common adverse event in cancer patients treated with antibody-drug conjugates (ADC) and we aimed to elucidate the potential mechanism of this toxicity. To investigate whether ADCs affect neutrophil production from bone marrow, an vitro assay was developed which hematopoietic stem cells (HSC) were differentiated neutrophils. Several antibodies against targets absent HSCs neutrophils conjugated MMAE via cleavable valine-citrulline linker (vcMMAE-ADC) or MMAF noncleavable...
Hypoxia is pervasive in cancer and other diseases. Cells sense adapt to hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it still an outstanding question why cell types differ their transcriptional response hypoxia.
Abstract Analysis of circulating tumor DNA (ctDNA) to monitor cancer dynamics and detect minimal residual disease has been an area increasing interest. Multiple methods have proposed but few studies compared the performance different approaches. Here, we compare detection ctDNA in serial plasma samples from patients with breast using tumor‐informed tumor‐naïve assays designed structural variants (SVs), single nucleotide (SNVs), and/or somatic copy‐number aberrations, by multiplex PCR, hybrid...
Effectiveness of marker-assisted selection (MAS) and quantitative trait locus (QTL) mapping using population-wide linkage disequilibrium (LD) between markers QTLs depends on the extent LD how it declines with distance in a population. Marker–QTL can be predicted from markers. Our previous work evaluated measures multi-allelic as predictors usable QTLs. Since single nucleotide polymorphisms (SNPs) are current marker choice for high-density genotyping LD-mapping QTLs, objective this study was...
Abstract Thrombocytopenia is a common adverse event in cancer patients treated with antibody–drug conjugates (ADC), including AGS-16C3F, an ADC targeting ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase-3) and trastuzumab emtansine (T-DM1). This study aims to elucidate the mechanism of action ADC-induced thrombocytopenia. expression platelets megakaryocytes (MK) was investigated shown be negative. The direct effect AGS-16C3F on evaluated using platelet rich plasma following activation...
Protection against endothelial damage is recognized as a frontline approach to preventing the progression of cytokine release syndrome (CRS). Accumulating evidence has demonstrated that interleukin-6 (IL-6) promotes vascular during CRS, although molecular mechanisms remain be fully elucidated. Targeting IL-6 receptor signaling delays CRS progression; however, current options are limited by persistent inhibition immune system. Here, we show trans-signaling promoted and inflammatory responses...