A5066528143- Plant Stress Responses and Tolerance
- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Plant Gene Expression Analysis
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Plant biochemistry and biosynthesis
- Plant nutrient uptake and metabolism
- Ovarian cancer diagnosis and treatment
- Plant Micronutrient Interactions and Effects
- MicroRNA in disease regulation
- Spectroscopy and Quantum Chemical Studies
- Signaling Pathways in Disease
- Liver Disease Diagnosis and Treatment
- Plant and animal studies
- Phytochemicals and Antioxidant Activities
- Molecular Biology Techniques and Applications
- Postharvest Quality and Shelf Life Management
- Hepatitis Viruses Studies and Epidemiology
- Horticultural and Viticultural Research
- Silk-based biomaterials and applications
- Helicobacter pylori-related gastroenterology studies
- Invertebrate Immune Response Mechanisms
- Genetic Associations and Epidemiology
- Protein Tyrosine Phosphatases
Ludong University
2016-2025
Nanchang University
2025
Jiangnan University
2023-2025
Shenyang Agricultural University
2024
Shanghai University
2024
Chongqing Medical University
2020-2024
Taixing People's Hospital
2024
Chongqing Public Health Medical Center
2024
Shanghai Sixth People's Hospital
2024
Shanghai Jiao Tong University
2024
Abiotic stresses adversely affect plant growth and agricultural productivity. According to the current climate prediction models, crop plants will face a greater number of environmental stresses, which are likely occur simultaneously in future. So it is very urgent breed broad-spectrum tolerant crops order meet an increasing demand for food productivity due global population increase. As one largest families transcription factors plants, NAC play vital roles regulating development processes...
Proline accumulation is a common response to salt stress in many plants. Salt also increased proline concentration roots, stems and leaves of Kosteletzkya virginica seedling treated with 300mM NaCl for 24h reached 3.75, 4.76 6.83 fold higher than controls. Further study on content under showed that increasing concentrations or time. The level peaked at 300 mM more 6-fold control, but 400mM fell back slightly along wilting symptom. To explore the cause behind accumulation, we first cloned...
Regulation of the process neuronal death plays a central role both during development CNS and in adult brain. The transcription factor myocyte enhancer 2 (MEF2) critical survival. Cyclin-dependent kinase 5 (Cdk5) mediates neurotoxic effects by phosphorylating inhibiting MEF2. How Cdk5-dependent phosphorylation reduces MEF2 transactivation activity remained unknown. Here, we demonstrate novel mechanism which Cdk5, conjunction with caspase, inhibits Using primary cerebellar granule neuron as...
Soil salinity is becoming the key constraints factor to agricultural production. Therefore, plant especially crops possessing capacities of salt tolerance will be great economic significance. The adaptation or stress involves a series physiological, metabolic and molecular mechanisms. Halophytes are kind organisms which acquire special mechanisms respond tress ensure normal growth development under saline conditions in their lengthy evolutionary adaptation, so understanding how halophytes...
Vanin-1 (VNN1) is a liver-enriched oxidative stress sensor that has been implicated in the regulation of multiple metabolic pathways. Clinical investigations indicated levels VNN1 were increased urine and blood diabetic patients, but physiological significance this phenomenon remains unknown. In study, we demonstrated hepatic expression was induced fasted mice or with insulin resistance. Gain- loss-of-function studies gluconeogenic genes glucose output, which led to hyperglycemia. These...
Honeysuckle (Lonicera japonica Thunb.) is a traditional medicinal plant in China that particularly rich chlorogenic acids, which are phenolic compounds with various properties. This study aimed to examine the effects of salinity stress on accumulation acids honeysuckle, through hydroponic experiments and field trials, mechanisms underlying effects. NaCl stimulated transcription genes encoding key enzymes synthesis leaves; accordingly, concentrations leaves were significantly increased under...
ABSTRACT Hepatitis B virus immune escape mutants have been associated with vaccine failure and reinfection of grafted liver despite prophylaxis, but their biological properties remain largely unknown. Transfection 20 such in a human hepatoma cell line identified many severe impairment virion secretion, which can be rescued to various extents by coexpression wild-type envelope proteins or introduction novel glycosylation site. Consistent role maintaining intra- intermolecular disulfide bonds,...
Abstract Cardiovascular diseases are the most common cause of death globally. Accurately modeling cardiac homeostasis, dysfunction, and drug response lies at heart research. Adult human primary cardiomyocytes (hPCMs) a promising cellular model, but unstable isolation efficiency quality, rapid cell in culture, unknown to cryopreservation prevent them from becoming reliable flexible vitro model. Combing use reversible inhibitor myosin II ATPase, (-)-blebbistatin (Bleb), multiple optimization...
Replication competent HIV-1 persists in a subpopulation of CD4+ T lymphocytes despite prolonged antiretroviral treatment. This residual reservoir infected cells harbors transcriptionally silent provirus capable reigniting productive infection upon discontinuation therapy. Certain classes drugs can activate latent virus but not at levels that lead to reductions size vivo. Here, we show the utility receptor targeting exosomes as an latency reversal agent (LRA). We engineered human cellular...
A CaO 2 -based multifunctional nanocomposite which possesses H O self-supplying, GSH depletion and calcium overload properties was prepared, the can enhance efficacy of CDT accelerate tumor apoptosis.
The transcription factor myocyte-enhancer 2 (MEF2) has been shown to be required for the survival of different types neurons. However, death- or survival-inducing second messenger pathways that regulate MEF2 activity remain fully elucidated. Membrane depolarization by KCl induces neuronal is dependent upon MEF2-mediated gene transactivation. Here we report membrane depolarizationinduced activation requires cAMP-protein kinase A (PKA) pathway. Inhibition cAMP-PKA pathway attenuates...
ABSTRACT Infection by hepatitis B virus (HBV) genotype C is associated with a prolonged viremic phase, delayed e antigen (HBeAg) seroconversion, and an increased incidence of liver cirrhosis hepatocellular carcinoma compared infection. Genotype also the more frequent emergence core promoter mutations, which increase genome replication are independently poor clinical outcomes. We amplified full-length HBV genomes from serum samples Chinese U. S. patients chronic infection transfected...
Abstract Background Glycine soja is a halophytic soybean native to saline soil in Yellow River Delta, China. Photosystem I (PSI) performance and the interaction between photosystem II (PSII) PSI remain unclear under salt stress. This study aimed explore adaptability terms of photosystems coordination. Results Potted was exposed 300 mM NaCl for 9 days with cultivated soybean, max , as control. Under stress, maximal photochemical efficiency PSII (Fv/Fm) (△MR/MR 0 ) were significantly decreased...
Abstract The aggregation of β‐amyloid (Aβ) has the neurotoxicity, which is thought to play critical role in pathogenesis Alzheimer's disease (AD). Inhibiting Aβ deposition and neurotoxicity been considered as an important strategy for AD treatment. 3,6'‐Disinapoyl sucrose (DISS), one oligosaccharide esters derived from traditional Chinese medicine Polygalae Radix, possesses antioxidative activity, neuroprotective effect anti‐depressive activity. This study was explore whether DISS could...
The size of leaves and fruits is a crucial agronomic economic trait for fruit trees. ‘Bartlett’ pear famous cultivar with succulent delicious cultivated globally. ‘Xiang shuomi’ bud sport the pear, discovered in our breeding work, exhibits enlarged fruits. However, specific regulatory mechanism this superior still elusive. In study, comprehensive transcriptome metabolome analyses were performed to explore differences gene expression metabolite accumulation between these two cultivars....